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Tolterodin

Tolterodin – the substance which is a competitive blocker of m-holinoretseptorov and being a part of the drugs used at treatment of urological diseases.

Pharmacological effect of substance толтеродин

Согласно инструкции толтеродин входит в состав препаратов Детрузитол, Уротол и РолитенThe substance which is a part of various drugs толтеродин is an antagonist of m-holinoretseptorov which are localized in sialadens and a bladder, has cholinolytic and spasmolytic effect.

Active 5-hydroxymethyl derivative a tolterodina it is highly specific concerning muskarinovy receptors, does not exert impact on other receptors and has, unlike receptors of sialadens, selectivity in relation to bladder receptors.

According to the instruction толтеродин, being a part of spasmolytic drugs, not only reduces activity of a bladder, but also reduces pressure of a detruzor and salivation, promotes easing and disappearance of an incontience of urine and increases an interval between urinations.

Release form

According to the instruction толтеродин is a part of the drugs Detruzitol, Urotol and Roliten produced in the form of tablets and capsules.

Analogs of a tolterodin

Detruzitol, Urotol and Roliten are analogs толтеродин the containing drugs on active ingredient. толтеродин the containing drugs on the mechanism of action and belonging to one pharmacological group carry medicines to analogs:

  • Vezikar;
  • Энаблекс;
  • Triptane;
  • Novitropan;
  • Spazmo-lit;
  • Спазмекс;
  • Toviaz.

Indications to use of a tolterodin

According to the instruction толтеродин appoint at treatment of a hyperactivity of a bladder which is shown in the form of an incontience of urine or frequent imperative desires to an urination.

Route of administration толтеродин

According to the instruction толтеродин the containing drugs accept inside 2 mg twice a day. In the presence of a liver or renal failure at the patient, and also at development of side effects the dose of drugs is reduced twice (1 mg twice a day). Treatment duration the drugs containing толтеродин makes from three to six months.

Contraindications

According to the instruction толтеродин it is contraindicated to use at hypersensitivity to substance, the delay of an urination resistant to treatment of a myasthenia, closed-angle glaucoma, heavy ulcer colitis and megacolon.

Side effects of a tolterodin

Согласно инструкции толтеродин назначают при лечении гиперактивности мочевого пузыряUse of drugs which part substance толтеродин according to reviews is causes side effects from various systems of an organism, namely:

  • Vision disorders, dizzinesses, headache, xerophthalmia, drowsiness and fatigue (nervous system and sense bodys);
  • Arterial hypertension (cardiovascular system);
  • Dryness in a mouth, nausea, dyspepsia, locks, a meteorism, diarrhea and an abdominal pain (digestive tract);
  • Infections of urinary tract and dysuria (urinogenital system).

Also the drugs containing толтеродин according to reviews cause allergic reactions and grippopodobny symptoms, increase in body weight, sinusitis, bronchitis and a xeroderma.

Medicinal interaction

Combined use of a tolterodin with anticholinergics strengthens therapeutic effect of substance and increases risk of development of side effects. Combined use of a tolterodin with agonists of muskarinovy cholinergic receptors reduces effect of substance.

At the parallel use of a tolterodin with fluoxetine the considerable inhibition of metabolism of a tolterodin at extensive metabolizant is observed.

 
 
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