Application instruction:
Tolterodin – the substance which is a competitive blocker of m-holinoretseptorov and being a part of the drugs used at treatment of urological diseases.
The substance which is a part of various drugs толтеродин is an antagonist of m-holinoretseptorov which are localized in sialadens and a bladder, has cholinolytic and spasmolytic effect.
Active 5-hydroxymethyl derivative a tolterodina it is highly specific concerning muskarinovy receptors, does not exert impact on other receptors and has, unlike receptors of sialadens, selectivity in relation to bladder receptors.
According to the instruction толтеродин, being a part of spasmolytic drugs, not only reduces activity of a bladder, but also reduces pressure of a detruzor and salivation, promotes easing and disappearance of an incontience of urine and increases an interval between urinations.
According to the instruction толтеродин is a part of the drugs Detruzitol, Urotol and Roliten produced in the form of tablets and capsules.
Detruzitol, Urotol and Roliten are analogs толтеродин the containing drugs on active ingredient. толтеродин the containing drugs on the mechanism of action and belonging to one pharmacological group carry medicines to analogs:
According to the instruction толтеродин appoint at treatment of a hyperactivity of a bladder which is shown in the form of an incontience of urine or frequent imperative desires to an urination.
According to the instruction толтеродин the containing drugs accept inside 2 mg twice a day. In the presence of a liver or renal failure at the patient, and also at development of side effects the dose of drugs is reduced twice (1 mg twice a day). Treatment duration the drugs containing толтеродин makes from three to six months.
According to the instruction толтеродин it is contraindicated to use at hypersensitivity to substance, the delay of an urination resistant to treatment of a myasthenia, closed-angle glaucoma, heavy ulcer colitis and megacolon.
Use of drugs which part substance толтеродин according to reviews is causes side effects from various systems of an organism, namely:
Also the drugs containing толтеродин according to reviews cause allergic reactions and grippopodobny symptoms, increase in body weight, sinusitis, bronchitis and a xeroderma.
Combined use of a tolterodin with anticholinergics strengthens therapeutic effect of substance and increases risk of development of side effects. Combined use of a tolterodin with agonists of muskarinovy cholinergic receptors reduces effect of substance.
At the parallel use of a tolterodin with fluoxetine the considerable inhibition of metabolism of a tolterodin at extensive metabolizant is observed.
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