Triampur compositum

Triampur compositum (or Triampur compositum) enters into group of diuretics of the combined structure.

Pharmacological action of Triampur compositum

Triampur compositum is directed to achievement of hypotensive and diuretic effects. Effect of drug is caused by pharmacological properties of the active components which are its part – a hydrochlorothiazide and Triamterenum.

The hydrochlorothiazide concerns to group of diuretics whose action is based on decrease in a reabsorption of ions of sodium in distal tubules. Substance also promotes a conclusion from an organism of potassium ions, sodium, water and chlorine, at the same time slowing down process of removal of calcium ions. Reception of high doses of drug involves strengthening of removal from a bicarbonate organism that is explained by oppression of a karboangidraza.

Action of Triamterenum is directed to strengthening of removal of ions of water and sodium from an organism and decrease in removal of ions of hydrogen and potassium. Besides, drug is capable to slow down process of exchange of ions of sodium for ions of hydrogen and potassium in distal tubules.

Triampur compositum differs in bystry absorption in digestive tract. The maximum therapeutic effect, according to the instruction to Triampur compositum, is reached later 4 h after reception.

Release form

Triampur compositum is issued in the form of roundish tablets of yellow color. Edges of tablets mown, on one of the parties is available risk. In number of 50 pieces of a tablet are packed into glass bottles.

Indications to use of Triampur compositum

Medical reviews of Triampur compositum allow to call drug the effective therapeutic remedy applied at treatment of arterial hypertension and an edematous syndrome of various origin (including at heart failure, a nephrotic syndrome and cirrhosis).

Contraindications

The instruction to Triampur compositum warns about existence of a number of contraindications to reception. Before use it is necessary to study their list given below:

• anury;
• renal failure in a chronic form;
• glomerulonephritis in an acute form;
• hepatic coma and prekoma, and also other heavy disturbances of functioning of a liver;
• the disturbances of exchange process of electrolytes which are not giving in to correction. Among them hyponatremia, hyperpotassemia, hypopotassemia, hypercalcemia;
• hypovolemia;
• pregnancy and lactic period;
• allergy to sulfonamides.

Also before use of Triampur compositum it is necessary to consider a number of cautions according to which drug is recommended to be taken with caution at the following types of indispositions:

• renal failure or liver;
• urolithiasis;
• gout;
• diabetes mellitus;
• deficit (or suspicion on it) folic acid. In particular, at such disease as the cirrhosis caused by excessive alcohol intake;
• risk of development of acidosis;
• age up to 18 years (influence of Triampur compositum on a children's organism is not established).

Application instruction of Triampur compositum

Pill is recommended to be taken inside, after a while after meal, washing down with water and not chewing. During use of Triampur compositum it is necessary to monitor completion of deficit of liquid in an organism.

The dosage of medicine is selected the doctor individually for each patient, however medical reviews of Triampur compositum call average dosages.

• At hypostases the initial dose has to make from 2 to 4 tablets which need to be accepted in the morning and during the lunchtime. Further the dose is adjusted proceeding from organism dehydration degree. The supporting Triampur compositum dosage in this case makes one tablet a day which is the best of all for accepting in the morning. Other option – two tablets which should be accepted every other day however both is in one day (one morning and one during the lunchtime). According to doctor's instructions the dose can be increased to 4 tablets a day (on two since morning and during the lunchtime);
• At arterial hypertension the initial dose of Triampur compositum makes two tablets in the morning and during the lunchtime. In case of need the dosage can be reduced to 2 tablets a day (the scheme of reception the same);
• At the accompanying therapy during treatment of heart failure cardiac glycosides the minimum dose of Triampur compositum makes 2 tablets a day. Increase in a dosage up to 4 tablets in days is allowed (on the 2nd in the morning and during the lunchtime);
• At decrease in functioning of kidneys the most admissible dose of Triampur compositum and analogs of medicine in days makes 1 tablet.

Side effects at reception of Triampur compositum

Use of Triampur compositum is capable to cause emergence of a wide range of side effects. It is necessary to notify the attending physician on emergence of the side reactions described below:

• vomiting, nausea, diarrhea, pains and gripes in epigastric area, locks, dryness in an oral cavity, thirst. Emergence of symptoms of hemorrhagic pancreatitis and acute cholecystitis is in rare instances possible;
• the increased drowsiness, the in-coordinate movements, fatigue, headache, irritability;
• muscular weakness, muscle tensions, spasms of gastrocnemius muscles;
• cardiopalmus, disturbances of a cordial rhythm and regulation of blood circulation, dizziness, faints, decrease in the ABP;
• the increase in blood of content of urea and creatinine which is temporary disturbance of concentration of sodium, chlorides, magnesium, potassium in an organism, increase in concentration of uric acid in blood that can cause formation of urinary stones and attacks of gout, increase in level of sugar in blood;
• various vision disorders, deterioration in short-sightedness;
• leukopenia, agranulocytosis, aplastic anemia, megaloblastny anemia, hemolysis;
• allergic reactions in the form of a small tortoiseshell, a skin itch, a system lupus erythematosus, fever, anaphylactoid reactions, emergence of icteric coloring of mucous membranes, scleras and skin. Lung hypostasis is in rare instances possible.

Analogs

Carry such drugs to analogs of medicine as:

• Diazide;
• Apo-Triazid;
• Triamtel;
• Vero-Triamtezid.

Storage conditions

The tablets Triampur compositum are recommended to be stored at most allowed temperature in 30 °C. The period of validity at observance of storage conditions makes 3 years.