Trigrim

Trigrim belongs to diuretics.

Release form, structure and packaging

In the instruction to Trigrim it is told that this medicine is produced in the form of round, biconvex tablets of white color. 1 tablet contains 2,5 mg of a torasemid. Corn starch, magnesium stearate, lactose, colloid silicon dioxide belongs to additional substances.

Do to also Trigry in the form of white, round, flat tablets which on the center have long to risk. 1 tablet contains 5 mg or 10 mg of a torasemid. Corn starch, magnesium stearate, lactose, colloid silicon dioxide belong to additional components.

In drugstores is on sale in the form of blisters on 10 pieces.

Pharmacological action of Trigrim

The instruction to Trigrim shows that the analyzed medicine and Trigrim's analogs belong to group of diuretic drugs. The principle of work of tablets is explained by connection of a torasemid with a kontransporter of Na+/2Cl-/K+ which is in an apical membrane of a thick segment of the ascending Henle's loop. For this reason it is possible to tell what in a human body significantly decreases or it is practically absolutely slowed down, and also the reabsorption of ions of sodium is prevented. Reduction of osmotic pressure of intracellular liquid, and also a water reabsorption is result of this process.

In responses to Trigrim it is noted that drug, thanks to the antialdosteronovy action which is much less expressed than at furosemide, practically does not provoke a hypopotassemia, despite big activity of the components and long action.

Indications to Trigrim's use

• The hypostases connected with a disease of kidneys, a liver, heart;
• Arterial hypertension of the first degree.

Contraindications

Anury, arrhythmia, the period of pregnancy and lactation, chronic renal failure, and also hypersensitivity to separate components of Trigrim.

Additional consultation is demanded by patients with a diabetes mellitus, liver diseases, gout.

Route of administration of Trigrim and mode of dosing

In the instruction to Trigrim it is told that this drug, and also Trigrim's analogs accept orally. Appoint the Trigry adult. It is allowed to use tablets to or during food.

If the patient has a hypostasis, then in a similar case drug is registered on 5 mg no more than 1 time a day. At urgent need the dosage can be increased to 20 mg (it is necessary to do it gradually) once a day. In certain cases it is necessary to use Trigrim to 40 mg within 24 hours.

If hypostasis which origin is connected with congestive heart failure is found in the patient, then the specialist prescribes such patient from 5 to 20 mg of drug a day. As it is told in the instruction to Trigrim, under observation of the health worker the dosage can be gradually increased at most to 200 mg.

At hypostases which origin is connected with a chronic renal failure, first of all, appoint 20 mg of the analyzed means a day. If there is an urgent need, then the dosage gradually increases (no more than 200 mg within 24 hours). It becomes for achievement of the best diuretic action.

At hypostases which are directly connected with cirrhosis prescribe the patient a daily dose of 5-10 mg. In certain cases this dosage can be doubled (it is necessary to do it gradually) that allows to reach the best diuretic effect. Till today's time medical researches which would tell about the possible effects arising at the patients accepting more than 40 mg of drug at liver diseases were not conducted.

If the patient has primary arterial hypertension, to him prescribe 2,5 mg of drug a day. Having increased a dose to 5 mg, arterial pressure remains without changes. The maximum effect of a course of treatment occurs only after 12 weeks.

In responses to Trigrim it is noted that patients of old age do not need additional consultation concerning a dosage and Trigrim's analogs.

Overdose

• Strengthening of a diuresis which involves a hypovolemia, disturbance of electrolytic balance;
• Lowering of arterial pressure, drowsiness;
• Consciousness opacification;
• Collapse;
• Failures in work of digestive tract.

The most efficient method of treatment is decrease in a dosage or full drug withdrawal for each specific patient. There is no special antidote today.

Medicinal interaction of Trigrim

At Trigrim's reception perception of a myocardium to cardiac glycosides significantly increases if at the same time in an organism there is not enough calcium and potassium. If to accept Trigrim or Trigrim's analogs together with laxatives or glucocorticoids, then process of removal from a potassium organism can amplify.

At the use with hypotensive medicines the analyzed drug strengthens their impact on an organism. At Trigrim's reception in the raised dosage, strengthening of toxic manifestations of a number of drugs (Cisplatinum, antibiotics) is possible.

Accepting salicylates in the raised dosages, increase of their toxic interaction on an organism is observed. Effect of antidiabetic drugs becomes weaker, also, as well as some vasoconstrictors (for example, Norepinephrinum and Epinephrinum).

NPVS in certain cases reduce hypotensive and diuretic influence of Trigrim. Action of Colestyraminum sometimes provokes decrease in absorbability of a torasemid from the alimentary system (it the numerous experiments made on animals confirm).

Side effects of Trigrim

In responses to Trigrim it is noted that among the most widespread side effects after reception of this drug reduction of concentration of leukocytes, erythrocytes and thrombocytes is observed.

Increase in blood serum of uric acid, lipids and even glucose is in some cases observed. There can be also a hypopotassemia. Very seldom there are failures in normal blood circulation, arterial pressure is broken.

Responses to Trigrim show that often there are problems with work of digestive tract, a loss of appetite, and also unpleasant feelings in an oral cavity. Quite seldom – pancreatitis and increase in activity of liver enzymes, an ischuria, and also increase in concentration of creatinine and urea in plasma.

Also frequent severe headaches, weakness, dizziness, confusion of consciousness, drowsiness, spasms in hands and legs, a hearing disorder, sight, and also full deafness, an itch and skin rashes meet.

Conditions and Trigrim periods of storage

To store far away from children at a temperature of 25 degrees. The period of validity is no more than 3 years.

Special instructions

Due to the lack of appropriate experiments it is not recommended to give to Trigry children up to 18 years. At long-term administration of drug it is necessary to conduct examination of an organism concerning the level of glucose, lipids and uric acid. In the presence of a hypopotassemia, hypovolemia Trigrim should be accepted only after full elimination of symptoms of the listed diseases.