Alotendin – the combined hypotensive drug containing the selection beta adrenoblocker and a blocker of slow calcium channels.
Dosage form – tablets: oblong, slightly convex from two parties, almost white or white color, with risky on one party and an engraving (Е 571, E 572, E 573 or E 574) on another, inodorous (on 7 pieces in the blister, in a pack of cardboard 4 or 8 blisters; on 10 pieces in the blister, in a pack of cardboard 3 or 9 blisters).
Active agents of drug: амлодипин and бисопролол (in the form of a fumarat), their contents, respectively, in tablets with an engraving:
Excipients: cellulose microcrystallic, sodium carboxymethylstarch (type A), magnesium stearate, silicon dioxide colloid anhydrous.
Alotendin it is necessary to accept inside on 1 tablet of 1 times a day, in the morning, swallowing entirely and washing down with enough liquid. Meal does not influence its efficiency.
The doctor defines a specific dose individually.
Classification of side effects: often (≥1/100 - <1/10), infrequently (≥1/1 000 - <1/100), it is rare (≥1/10 000 - <1/1 000), is very rare (<1/10 000), frequency is unknown (on the basis of the available data assessment cannot be carried out).
Possible undesirable reactions:
Separate cases of such heavy reactions as arrhythmia (ciliary arrhythmia and ventricular tachycardia), stenocardia, myocardial infarction are known. They are connected with a basic disease or using Alotendin, authentically it is not established.
Drug should not be cancelled sharply, especially at coronary heart disease since deterioration in a clinical state is possible. It is recommended to reduce a dose gradually.
Alotendin reduces secretion of the lacrimal liquid, it should be considered to patients who carry contact lenses.
In some cases drug can influence the speed of reactions and ability to concentration of attention, especially at the beginning of use, at change of a dose and simultaneous alcohol intake.
Alotendin it is not necessary to apply along with blockers of calcium channels of the I class (for example, verapamil) and the III class (diltiazem) as they negatively influence sokratitelny ability, arterial pressure and atrioventricular carrying out. Intravenous administration of verapamil to the patients receiving beta adrenoblockers (бисопролол) can lead to the expressed arterial hypotension and an atrioventricular block.
Alotendin is not recommended to combine with anti-hypertensive drugs of the central action (for example, metildopy, moksonidiny, a clonidine, rilmenidiny) as such combination can lead to a vazodilatation, an urezheniye of heart rate and minute volume of heart. In case of sharp drug withdrawal the risk of development of the withdrawal which is shown in the form of hypertensia increases.
Alotendin it is necessary to apply with care at the same time with the following drugs: nitrates of long action, beta adrenoblockers, thiazide diuretics, peroral hypoglycemic drugs, non-steroidal anti-inflammatory drugs, antibiotics, trinitrate glyceryl drugs for sublingual use.
In a combination with the following medicines Alotendin it is also necessary to apply carefully:
At patients to whom the general anesthesia is carried out beta adrenoblockers (in this case бисопролол) reduce the frequency of arrhythmia and ischemia of a myocardium during induction of anesthesia, an intubation and in the postoperative period. Now maintenance of beta blockade is recommended to be provided perioperatsionno. The anesthesiologist has to remember beta blockade since there is a potential probability of interaction with other drugs owing to what easing of reflex tachycardia is possible, development of a bradyarrhythmia, oppression of a reflex opportunity to compensate blood loss. If before surgical intervention it is necessary to stop Alotendin's reception, it is necessary to do it gradually, having completely completed administration of drug approximately in 48 hours prior to anesthesia.
Meflokhin can increase risk of bradycardia. Monoamine oxidase inhibitors (except for inhibitors like B) can strengthen hypotensive effect of a bisoprolol and increase risk of development of hypertensive crisis. The possibility of simultaneous use of these medicines in each case is solved individually.
To store at a temperature up to 25 °C in the place, dry, dark and unavailable to children.
Period of validity – 2 years.
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