Azawounds – a wide range of bactericidal action the antibiotic of group of cephalosporins (the III generation) intended for parenteral administration.
Dosage form of Azaran – powder for preparation of solution for intravenous and intramuscular administration: powdery weight from white with a yellowish shade till white color (on 1,0 g in the bottles of colourless glass corked by the combined cover from plastic, rubber and metal with function of control of the first opening; 1, 10 or 50 bottles in a cardboard pack).
1 bottle contains active ingredient: цефтриаксон sodium (in terms of цефтриаксон) – 1,0 g.
Azawounds apply to therapy of the following infectious and inflammatory diseases caused by the microorganisms sensitive to a tseftriakson:
Also drug is used in postoperative practice for prevention and treatment of infectious complications.
Relative (drug is used with care, in connection with the increased risk of side effects):
As цефтриаксон gets through a placenta, at pregnancy therapy by Azaran is possible only according to indications, in case of exceeding of estimated advantage for mother over potential risk for a fruit.
In need of use of drug in the period of a lactation it is required to resolve an issue of breastfeeding interruption since цефтриаксон it is allocated with maternal milk.
The solution received from powder is entered intramusculary (in oil), either intravenously (in/in) struyno or kapelno, 1 time a day if there are no other appointments.
The recommended average daily dose:
To children 12 years with the body weight of ≥50 kg are younger apply adult doses.
Solution in a daily dose of 50 mg/kg and is more entered infusionally for half an hour.
Therapy course duration usually no more than 10 days. After removal of symptoms of a disease and normalization of temperature it is necessary to continue administration of drug 2-3 more days.
The recommended dosing in special cases:
Dose adjustment is required at heavy degree of a renal failure with the clearance of creatinine (CC) of ≤10 ml/min., the daily dose of a tseftriakson at the same time should not exceed 2000 mg.
In dose adjustment of a tseftriakson patients have no need: with a moderate renal failure at normal function of a liver; with abnormal liver functions at normally functioning kidneys.
At a combination of a renal and liver failure regular control of concentration of a tseftriakson in plasma, and according to indications correction of its dose is carried out.
After carrying out dialysis patients do not need additional administration of drug as holding a procedure does not promote removal of a tseftriakson. But the hemodialysis can change the speed of its removal therefore control of concentration of drug in a blood plasma is important for possible dose adjustment.
Solution for introduction in oil can be prepared for one of two recommended ways:
Solution for in/in introductions prepares as follows:
Freshly cooked solutions from powder Azaran are stable at the room temperature during 6 h and no more than 24 h at a temperature of 2-8 °C (storage in the refrigerator).
Azawounds it is applied only in the conditions of a hospital!
In case of long therapy it is necessary to carry out regular control of a picture of peripheral blood, and also indicators of a functional condition of kidneys and a liver.
Occasionally, at ultrasound examination (ultrasonography) of a gall bladder blackouts which disappear independently after drug withdrawal (even are visible if this phenomenon is followed by pain in right hypochondrium, it is recommended to carry out a symptomatic treatment and to continue use of an antibiotic).
It is impossible to use ethanol at therapy by Azaran as there is a probability of development of the following disulfiramopodobny reactions: nausea, vomiting, rush of blood to the person, spastic pains in epigastric area, a headache, a lowering of arterial pressure (ABP), an asthma, tachycardia.
The elderly and weakened patients need in a complex with tseftriaksony purpose of vitamin K.
Before Azaran's use (as well as other cephalosporins) detailed collecting the anamnesis, but, despite its results is carried out, it is impossible to exclude a possibility of development of an acute anaphylaxis. The state demands immediate treatment: at first in/in introductions of Epinephrinum, and then glucocorticosteroids.
According to the researches in vitro it is revealed that цефтриаксон (as well as other cephalosporins) the blood serum bilirubin connected with albumine is capable to force out. Thereof at newborns with a hyperbilirubinemia, especially premature, it is required to apply цефтриаксон with a bigger care.
To store in the dark place, at a temperature of 15-25 °C. To protect from children.
Period of validity – 3 years.
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