Cyclodolum

Cyclodolum belongs to central N-holinoblokatoram. Enters into group of anticholinergics.

Pharmacological action of Cyclodolum

Due to ability to render peripheral and central miyelorelaksiruyushchy and holinoblokirushchy actions, Cyclodolum – one of the main drugs used at parkinsonism. Medicine helps to reduce a tremor, exerts weak impact on a bradykinesia and rigidity.

Thanks to the fact that Cyclodolum has M-holinoblokiruyushchee effect on a peripheral nervous system administration of drug promotes reduction poto-and salivations. Also medicine is capable to have effect of local anesthetic. The general duration of therapeutic effect after reception makes from 6 to 12 h, the maximum action lasts from 2 to 3 h. After oral administration of Cyclodolum drug begins to work actively later 1 h. At introduction in oil this time is reduced to 10 minutes, and the effect can last to 12 h.

Release form

According to the instruction to Cyclodolum, the only form of production of drug are tablets weighing active agent of 0,001, 0,002 or 0,005 g. Tablets have white color, rounded shape, a flat surface. Are packed into a pack in number of 50 pieces.

Indications to use of Cyclodolum

Medical reviews of Cyclodolum describe drug as an effective remedy at the following diseases of a nervous system:

• parkinsonism of various origin;
• frustration of extrapyramidal system which are followed by the raised muscle tone and existence of hyperkinesias (the violent automatic movements caused by involuntary reductions of muscles).

Contraindications

Cyclodolum and analogs of drug are strong substances. In this regard their use is not recommended for reception in certain cases. You should not use drug if:

• there is a hypersensitivity to drug components, in particular to a trigeksifenidil;
• the patient suffers from an urination delay;
• adenoma (prostatauxe) with existence of the remains of urine is diagnosed;
• there are diseases of digestive tract of obstructive character;
• fibrillation of auricles is diagnosed;
• age of the patient less than 5 years;
• there is confirmed pregnancy.

Application instruction of Cyclodolum

The instruction to Cyclodolum recommends to begin administration of drug with minimum resolved doses which then, in case of need and under control of the doctor, gradually raise. Depending on a type of a disease the minimum doses differ.

• At Parkinson's syndrome it is recommended to begin administration of drug with 1 mg of a trigeksifenidil of a hydrochloride (the main operating Cyclodolum component) a day. If necessary a dose each 3-5 days increase to 3 mg a maximum. It is necessary to be guided by a condition of the patient and achievement of optimum effect of treatment. The maintenance dose at this disease reaches 16 mg a day, the lower level – 6 mg. It is necessary to distribute this quantity on 3-5 receptions. It is also necessary to consider that reception of Cyclodolum in the doses exceeding 20 mg a day is not recommended.
• At extrapyramidal frustration accept up to 16 mg of drug a day (the lower level – 2 mg). The dosage is selected depending on expressiveness of symptoms. Most resolved dose also makes 20 mg.
• At anticholinergic therapy the dose of drug should be regulated smoothly, every day raising an initial dose (2 mg) to the minimum effective supporting dosage. At the same time the most admissible quantity makes 50 mg a day.
• For treatment of children and teenagers aged from 5 up to 17 years Cyclodolum is appointed only as therapy at extrapyramidal dystonias. The most admissible dose should not be higher than 40 mg a day.

General recommendations for reception of Cyclodolum: tablets should be used regardless of meal, washing down with enough liquid (about 180 ml). If prior to treatment at the patient hypersalivation (the increased salivation) was observed, it is better to accept Cyclodolum after food. During treatment by drug emergence of dryness in an oral cavity is possible. In this case Cyclodolum needs to be accepted to food, controlling emergence of nausea.

Drug should not be cancelled sharply, treatment demands gradual end at which the dosage smoothly decreases within 1-2 weeks. In case of non-compliance with these recommendations the aggravation of symptoms of a disease is possible.

Duration of treatment is defined only by the doctor in a specific case.

Side effects of Cyclodolum

According to medical reviews of Cyclodolum drug is capable to influence various systems of bodies, causing emergence of undesirable reactions. At detection of the symptoms described below consultation of the doctor is recommended:

• accommodation disturbance, headache, irritability, drowsiness, vomiting, nausea. Emergence of symptoms of the increased concern, disturbances of memory, consciousness and a dream is in rare instances possible. Even more rare – dyskinesia (involuntary movements);
• dryness in an oral cavity, locks, decrease in sweating, disturbance of an urination, tachycardia. More rare – a mydriasis, bradycardia, vision disorders;
• allergic enanthesis.

As a rule, symptoms pass by itself, or are eliminated by reduction of a dose or frequency of reception.

Special instructions

Use of Cyclodolum and analogs of drug by patients whose age exceeds 60 years, has to be followed by constant medical control in connection with high probability of deterioration in thinking and memory during reception.

Control of intraocular pressure at treatment by Cyclodolum is obligatory.

At administration of drug development of medicinal dependence is possible.

The use of high doses, overdose are capable to cause emergence of hallucinations, nonsense, disturbance of orientation in time and space.

It is necessary to be careful at management of transport and performance of other potentially dangerous kinds of activity during treatment of Cyclodolum.

Cyclodolum analogs

The following medicines belong to the drugs having similar properties with Cyclodolum:

• Parkopanum;
• Treminum;
• Antitr;
• Benzhexolum hydrochloride;
• Parkinsanum;
• Pacitanum;
• Trihyl, etc.

Cyclodolum storage conditions

It is extremely necessary to preserve Cyclodolum against access for children. Drug is stored in the dry place, far from sunshine where temperature is not above 25 °C. The period of validity at observance of storage conditions makes 5 years.