Colchicine
Application instruction:
Colchicine – the medicine having antiinflammatory and antigouty effect.
Form of release and structure
Colchicine is produced in the form of tablets (in packaging on 20 pieces).
Active agent is a part of 1 tablet: colchicine – 1 mg.
Indications to use
- Bekhchet's disease;
- Gout (for stopping and the prevention of attacks);
- Periodic peritonitis;
- Other bad attacks of a chondrocalcinosis.
Contraindications
- Liver and renal failure in an acute current;
- Pregnancy (use is possible only according to strict indications);
- Hypersensitivity to medicine components.
The Colchicine uses by the feeding women given about an opportunity are absent.
Care is demanded by purpose of drug at functional disturbances of a liver and/or kidneys.
Route of administration and dosage
Colchicine should be accepted inside.
The recommended dosing mode:
- First day: 1 tablet in the morning and 2 tablets in the evening (a daily dose – 3 mg);
- Second and third days: on 1 tablet in the morning and in the evening (a daily dose – 2 mg);
- Next days: 1 tablet in the evening (a daily dose – 1 mg).
At acute gouty arthritises with the preventive purpose appoint on 1 tablet a day (in the evening).
Side effects
- Urinary system: functional disturbances of kidneys;
- Alimentary system: diarrhea, vomiting, nausea, abdominal pain;
- Hemopoietic system: leukopenia; at long therapy – an agranulocytosis;
- Dermatological reactions: at long therapy – an alopecia.
Special instructions
At a long medical course it is recommended to carry out control of a picture of peripheral blood systematically.
Medicinal interaction
At joint purpose of Colchicine with some drugs there can be following effects:
- Cyanocobalamine: decrease in its absorption from digestive tract;
- Antibiotic drugs of group of macroleads: toxic influence of colchicine, in particular at patients with the previous functional disturbances of kidneys.
Terms and storage conditions
To store in protected from light, the place, unavailable to children.
Our kidneys are capable to clear three liters of blood in one minute.
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