Fluoxetine

Fluoxetine is the medicine relating to group of antidepressants.

Pharmacological effect of Fluoxetine

Fluoxetine belongs to propylamine derivatives. The mechanism of its action is caused by selective (selection) ability to suppress the return serotonin reuptake in the central nervous system. At the same time drug exerts the minimum impact on exchange of dopamine, acetylcholine and noradrenaline.

In the instruction to Fluoxetine it is noted that this medicine reduces feeling of tension and fear, removes uneasiness, improves mood. Fluoxetine does not cause orthostatic hypotension, does not exert a negative impact on a myocardium.

According to reviews it is necessary to accept Fluoxetine for achievement of full therapeutic effect not less than one-two weeks.

Fluoxetine is well soaked up from digestive tract. Meal does not exert noticeable impact on its bioavailability.

Indications to Fluoxetine use

Medicine is accepted in the following cases:

• Treatment of depressions of varying severity;
• Persuasive states;
• Disorders of appetite (anorexia, bulimia);
• Complex therapy of alcoholism.

Fluoxetine route of administration

For treatment of depressions usually appoint reception drug on 1 tablet (20 mg) once a day, it is desirable in the morning. At insufficient efficiency the dose can be increased to two tablets (40 mg) a day. The most admissible daily dose are 4 tablets (80 mg), and for elderly patients – 3 tablets (60 mg).

According to the instruction Fluoxetine for treatment of bulimia is appointed on one tablet three times a day.

For therapy of persuasive states appoint from 1 to 3 tablets (20-60 mg) a day.

Duration of a course of treatment depends on severity of a disease, efficiency of the carried-out therapy. The minimum duration of a course – not less than 3 weeks, and maximum – several years.

Side effects

Therapy by this medicine can lead to development of side effects:

• From a nervous system – a headache, an adynamy, dizziness, weakness, hypererethism, a mania, uneasiness, increase in risk of commission of a suicide;
• From a digestive tract – a loss of appetite, dyspepsia, dryness in a mouth or on the contrary the increased salivation (sialosis);
• From other bodies – decrease in a libido, the increased sweating, decrease in body weight, allergic reactions.

When using Fluoxetine side effects quite often demand its cancellation from the carried-out therapy.

Contraindications

According to the instruction Fluoxetine is contraindicated in the following cases:

• Individual intolerance of drug;
• Bladder atony;
• Closed-angle glaucoma;
• The expressed liver or renal failure;
• Treatment by MAO inhibitors;
• Pregnancy and lactation;
• The increased tendency to a suicide;
• Prostatauxe.

Use of Fluoxetine for the patients suffering from Parkinson's syndrome, epilepsy, a diabetes mellitus or sharp exhaustion demands extra care.

Interaction of Fluoxetine with other drugs

This medicine strengthens effects of alcohol, Diazempam and the drugs lowering glucose level in blood.

Fluoxetine at a concomitant use with tricyclic antidepressants increases concentration of the last in a blood plasma almost twice.

According to reviews it is not necessary to appoint Fluoxetine the patient against the background of performing electroconvulsive therapy since in this case weighting of epileptic seizures is possible.

Overdose

At accidental or deliberate reception of a high dose of Fluoxetine the patient needs rendering urgent medical care. There is no specific antidote therefore the symptomatic treatment is carried out. For acceleration of removal of drug from an organism carry out a gastric lavage and give inside sorbents.

Release form

Fluoxetine is produced in the capsules containing 20 mg of active agent.

Storage conditions

Drug is released from drugstores only according to the recipe of the doctor. Store at the room temperature in the unavailable place for children. A period of validity – three years. Fluoxetine cannot be used after the termination of the period of validity specified on a box.