Ftivazidum
Application instruction:
Ftivazidum – 
medicine against tuberculosis.
Structure and form of release of Ftivazidum
Drug is produced in the form of tablets. One tablet contains the operating component – Ftivazidum of 100 mg.
In blisters on 10 tablets or in banks from dark glass on 100 tablets.
Pharmacological action of Ftivazidum
According to the instruction Ftivazidum is the antitubercular drug derivative of hydrazide of isonicotinic acid.
It is active concerning Mycobacterium tuberculosis. Use of drug slows down metabolic and oxidizing processes, leads to damage of a membrane of mycobacteria, synthesis of nucleic acids oppresses, has effect on mycobacteria at all levels.
Indications to use of Ftivazidum
According to the instruction Ftivazidum is intended for treatment of all forms of tuberculosis at children and adults.
Route of administration and mode of dosing
Drug is accepted inside.
As a rule, the dosage for adults makes on 5 tablets two-three times a day. Children accept drug at the rate of 30-40 mg on weight kg the day divided into three receptions.
At a tubercular lupus the dosage makes 3 tablets from three to four times a day. Duration of treatment is 1-1,5 months. If necessary, it is possible to pass a repeated course of treatment after a two-month break.
The maximum dosage of drug for adults: one-time – 10 tablets, daily – 20 tablets. For children: daily – 15 tablets.
Contraindications
In the instruction to Ftivazidum the following contraindications are specified:
- epilepsy;
- stenocardia;
- hypersensitivity to drug;
- chronic heart failure 2-3 degrees;
- diseases of kidneys or liver;
- organic lesions of TsNS;
- alcoholism;
- chronic renal failure;
Side effects
According to reviews Ftivazidum 
can cause the following by-effects:
- Sense bodys and nervous system: dizziness, euphoria, headache, increased fatigue, memory disturbance, sleep disorder, depressions, psychotic reactions, optic neuritis, peripheral neuritis.
- Digestive tract: a loss of appetite, vomiting, dryness in a mouth, nausea, hepatitis, pain in epigastriums.
- Cardiovascular system and system of a hemopoiesis: the raised bleeding, a cardialgia.
- Allergic reactions: skin rash, fever.
- Endocrine system: menorrhagia, gynecomastia.
According to reviews Ftivazidum can cause increase of epileptic seizures in patients with epilepsy.
Use of Ftivazidum during pregnancy and breastfeeding
During pregnancy drug needs to be taken with caution, considering advantage for mother and potential risk for a fruit.
For the period of reception of Ftivazidum it is recommended to interrupt breastfeeding.
Medicinal interaction of Ftivazidum
Ftivazidum strengthens side effects of alcohol, paracetamol, carbamazepine, benzodiazepines, gepatoksichesky drugs. Also strengthens action of antiagregant and anticoagulants, and reduces – glucocorticoids and mineralokortikoid.
Absorption of drug is slowed down by antacids.
Special instructions
For the period of administration of drug it is recommended to conduct ophthalmologic examination regularly.
Along with Ftivazidum it is reasonable to appoint B6 and B1 vitamins for prevention of development of neuritis.
During use of drug it is necessary to avoid driving and other mechanisms demanding the increased concentration of attention.
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