Hartil

Hartil treats group of APF inhibitors.

Pharmacological action of Hartil

At the expense of the active components which are its part Hartil possesses cardioprotective and hypotensive actions.

Release form

Hartil is issued in the form of tablets with various maintenance of the active operating component – a ramiprila. There are three kinds of tablets: on 2,5 mg (yellow color of tablets), 5 mg (salmoncolored color) and 10 mg (white color). For the rest tablets are similar and have the oval form with risky, a facet and engravings of "R2", "R3" and "R4" respectively.

Indications to Hartil's use

According to the instruction to Hartil drug should be accepted as medicine at the following types of diseases:

• at arterial hypertension;
• at chronic heart failure;
• at the heart failure which arose after the postponed acute myocardial infarction at patients with a stable hemodynamics;
• at a nephropathy of diabetic type, chronic diffusion diseases of kidneys.

Medical reviews of Hartila recommend drug as the means allowing to reduce risk of development of a myocardial infarction, "coronary death" or a stroke at patients from the ischemic heart diseases including which transferred aortocoronary shunting, a myocardial infarction, chrezkozhny transluminal coronary angioplasty.

Contraindications

Hartil and analogs of drug is not recommended to use in cases which list is given below:

• Quincke's disease in the anamnesis, including connected with the therapy performed earlier APF inhibitors;
• high sensitivity to components of composition of drug, including – to a ramipril;
• stenosis of an artery of the only kidney, bilateral stenosis of renal arteries, significant from the point of view of hemodynamics;
• unstable hemodynamics and/or arterial hypotension;
• any trimester of pregnancy, and also breastfeeding period;
• the hyper aldosteronism is primary;
• renal failure.

Application instruction of Hartil

According to the instruction to Hartil drug is used orally. The binding to time of meal does not exist. Tablets should not be chewed, however it is necessary to wash down with amount of liquid not less than 200 ml. Hartil's dosage for each patient is established by individually attending physician, at the same time there are recommended medicine doses which depend on a specific disease.

At arterial hypertension it is necessary to begin with a single dose 2,5 mg of Hartil a day. If necessary the dose is raised by each 2-3 weeks, doubling it. At the same time the maximum dosage should not be higher than 10 mg of medicine a day.

At heart failure in a chronic form it is recommended to begin Hartil's reception with 1,25 mg daily. It is possible to double a dose each 2-3 weeks. The maximum also makes 10 mg a day.

At treatment after the postponed myocardial infarction Hartil's reception is recommended to be begun several days (from 2 to 9) later after an acute stage of a disease. The initial dosage depends on a condition of the patient and time which passed from the moment of an acute phase and, as a rule, makes 2 tablets on 2,5 mg twice a day (or an equivalent dosage of tablets on 1,25 mg). As necessary the daily dose can be doubled. The most admissible daily dosage makes 10 mg.

At nefropatiya (diabetic and not diabetic) the instruction to Hartil orders to take medicine on 1,25 mg once a day. The dose can be raised, doubling each 2-3 weeks. In days no more than 5 mg are recommended to take medicine.

At prevention of a stroke, myocardial infarction or a lethal outcome from cardiovascular disturbances the initial dose of Hartil makes 2,5 mg. At good tolerance of drug the dose in a week of reception is doubled, in its three weeks it is possible to raise twice again. At most in days – 10 mg.

Side effects of Hartil

Medical reviews of Hartila note probability of emergence of side effects. Their list is very extensive and demands detailed studying. It is recommended to examine the most widespread side effects before drug intake:

• orthostatic hypotension, decrease in the ABP. In rare instances – arrhythmia, emergence of disturbances of blood circulation of bodies, ischemia of a myocardium and brain;
• strengthening of a proteinuria, renal failure, decrease in a libido, reduction of volume of urine;
• weakness, headache, drowsiness, nervous irritability, tremor, disturbances of mood, uneasiness, muscular spasm;
• perception disturbances (sense of smell, hearing, taste, sight) and vestibular disturbances;
• loss of appetite, nausea, lock/diarrhea, pancreatitis, dryness in an oral cavity, vomiting;
• asthma, bronchospasm, rhinorrhea, sinusitis, rhinitis, bronchitis, dry cough;
• urticaria, itch, rash on skin, conjunctivitis;
• thrombocytopenia, anemia, the lowered concentration of a hematocrit and hemoglobin, thrombocytopenia, neutropenia, leykotsitopeniya, agranulocytosis, hemolitic anemia, pancytopenia;
• spasms, hyperthermia, alopecia, sweating;
• hyperpotassemia, giperkreatininemiya, increase in level of activity of hepatic transaminases and level of an urea nitrogen, hyponatremia.

Hartil's use during pregnancy is capable to cause side effects on a fruit: various disturbances of development and function of kidneys, decrease in the ABP of the child, hypoplasia of lungs and skull, contracture of extremities, deformation of a skull.

Precautionary measures

During Hartil's use and analogs constant medical control is extremely necessary. Especially it concerns situations of the first administration of drug and increase in its dosage. During 8 h from the moment of administration of drug repeated measurement of the ABP is recommended.

Before drug intake it is necessary to correct a hypovolemia and dehydration.

Patients with defeat of renal vessels, disturbance of functions of kidneys and after transplantation of a kidney need especially careful observation during Hartil's reception.

There are no sufficient data concerning Hartil's reception by children and patients during dialysis.

In case of decrease in the ABP to patients accepting Hartil it is recommended to refuse performance of those types of activity which demand the increased concentration of attention.

Hartil's analogs

The following medicines belong to analogs of drug:

• Вазолонг;
• Amprilan;
• Korpril;
• Dilaprel;
• Piramil;
• Ramikardiya;
• Ramigamma;
• Ramipril;
• To Tritatsa.

Storage conditions

It is recommended to store Hartil in the darkened place, at a temperature not above 25 °C. At observance of conditions the period of validity makes 1,5 years.