Imet

Imet – non-steroidal anti-inflammatory drug with analgetic and antipyretic property.

Form of release and structure

Dosage form – tablets, coated (on 10 pieces in blisters, in a cardboard pack 1, 2 or 3 blisters).

Active agent – an ibuprofen, in 1 tablet – 400 mg. Also auxiliary components are a part.

Indications to use

Imet's use is shown for a symptomatic treatment of a pain syndrome of weak and moderate intensity:

• Musculoskeletal system diseases: an osteoarthrosis, the pseudorheumatism ankylosing a spondylitis and other inflammatory and degenerative pathologies; psoriasis arthritis, an articulate syndrome at an exacerbation of gout;
• Bursitis, tendovaginitis;
• Posttraumatic joint pains and muscles;
• Tooth and headache;
• Acute respiratory viral infections (as a part of complex therapy);
• Algodismenorey, adnexitis;
• Feverish conditions of various genesis.

Contraindications

• Heavy renal failures and/or liver;
• Severe form of cardiovascular insufficiency;
• Round ulcers, hemorrhage, including in the anamnesis;
• The functional disturbances of system of a hemopoiesis connected with tendency to active bleedings including gastrointestinal and cerebrovascular bleedings;
• Aspirinovy triad (in the anamnesis);
• Simultaneous use of the selection inhibitors of cyclooxygenase-2 or other non-steroidal anti-inflammatory drugs;
• Age up to 12 years;
• III trimester of pregnancy;
• Hypersensitivity to components of drug and other non-steroidal anti-inflammatory drugs.

Imet with care is recommended to appoint: to patients of advanced age because of the increased risk of development of bleedings, including with a lethal outcome; at a system lupus erythematosus, arterial hypertension, the mixed collagenose, cardiovascular insufficiency, a renal failure and a liver; in I and II trimesters of pregnancy, during breastfeeding; directly after surgical intervention.

Route of administration and dosage

Pill is taken inside, without chewing, in time or right after food, washing down with enough water.

The dose and duration of use are appointed by the doctor individually, considering clinical indications and a condition of the patient.

The recommended daily dosing:

• Pain syndrome of weak and moderate intensity: on 200-400 mg 2-3 times a day with an interval between receptions not less than 4 hours;
• Feverish conditions of various genesis: 200-400 mg of 1 times a day, if necessary are allowed repeated reception in 4 hours.

The maximum daily dose for patients is more senior than 15 years – 1200 mg, 12 years – 1000 mg are more senior than children.

For patients of advanced age dose adjustment of drug is not required.

Side effects

• From digestive tract: nausea, pain in epigastric area, vomiting, dryness in a mouth, heartburn, a meteorism, digestion disturbance, diarrhea or a lock; perhaps – cankers of a stomach and duodenum (including with perforation and bleeding), gastrointestinal bleedings, a stomacace, an exacerbation of colitis and disease Krone, an esophagitis, gastritis, pancreatitis; in isolated cases – a duodenitis;
• From cardiovascular system: heart failure, arrhythmia, arterial hypertension; perhaps – development of a myocardial infarction (at reception of high doses);
• From a nervous system: dizziness, headache, sleep disorders, irritability, increased fatigue; perhaps – a depression, emotional lability, feeling of causeless alarm and other psychotic reactions; in isolated cases – spasms, psychomotor excitement;
• From system of a hemopoiesis: thrombocytopenia, anemia, pancytopenia, agranulocytosis, leukopenia; patients with the broken function have systems of a hemopoiesis – erosive damages of a mucous membrane of a mouth, a pharyngalgia and/or in muscles, fervescence, a depression; perhaps – hematomas, skin hemorrhages, nasal bleedings and other bleedings of an unspecified etiology;
• From gepatobiliarny system: functional disturbances of a liver, toxic damage of a liver, hepatitis, acute liver failure, gepatorenalny syndrome;
• From sense bodys: a vision disorder (at prolonged use), including dryness of a mucous membrane and color perception of an eye, decrease in clearness of sight; perhaps – a hearing disorder, a sonitus;
• From urinogenital system: hypostases (it is preferential at patients with arterial hypertension and/or a renal failure), a necrosis of renal nipples, intersticial nephrite, a hyperuricemia, a nephrotic syndrome, a polyuria, cystitis, an oliguria; in isolated cases – a hamaturia, a glomerulonephritis;
• Allergic reactions: itch, skin rash, rhinitis, multiformny erythema, small tortoiseshell, anaphylactoid reactions, including paraglossa and throats, arterial hypotension, acute anaphylaxis; perhaps – development of a bronchospasm and bronchial asthma in patients with the increased individual sensitivity;
• From integuments: dryness of integuments, Stephens-Johnson's syndrome, alopecia, Lyell's disease, photosensitivity;
• Others: an arterial thromboembolism, a stroke (at prolonged use in high doses).

Besides, undesirable effects of use of Imet can become an aggravation or development of infectious diseases: a necrotizing fasciitis, aseptic meningitis (symptoms – a stiff neck, a hyperthermia, nausea, a headache, vomiting, consciousness disturbance).

Special instructions

Patients of advanced age in an initiation of treatment should appoint the minimum single dose, if necessary and normal portability of its drug can increase gradually.

In case of development of allergic reactions the patient needs to stop reception and to see urgently a doctor behind consultation.

At prolonged use of Imet carrying out regular control of a gemogramma, function of kidneys is recommended.

At development of gastrointestinal bleeding which signs are severe pain in epigastric area vomiting of color of a coffee thick, a black chair, it is necessary to cancel administration of drug and to see a doctor.

At an exacerbation of infectious pathology or development of a new infection against the background of use of an ibuprofen, the patient should see the attending physician for purpose of antibacterial therapy.

During Imet's use patients are recommended to refrain from performance of potentially dangerous types of works, including from control of vehicles and mechanisms.

Medicinal interaction

At a concomitant use of Imet reduces anti-hypertensive action of an amlodipin, captopril, inhibitors of an angiotensin-converting enzyme (APF) and beta adrenoblockers; pharmacological effect of furosemide, hypothiazid, Hydrochlorthiazidum and other diuretics.

Drug strengthens effect of anticoagulants, increasing risk of development of gastrointestinal bleedings.

The ibuprofen in combination with lithium drugs, Phenytoinum, digoxin promotes increase in level of their concentration in a blood plasma.

At a concomitant use drug forces out the indirect anticoagulants derivative of sulphonylurea, peroral hypoglycemic means and derivatives of hydantoin from bonds with proteins of a blood plasma; increases toxic action of a methotrexate and Baclofenum.

At simultaneous use of Imet:

• Colestyraminum – promotes decrease in absorption of an ibuprofen in digestive tract;
• Warfarin – promotes development of a microhematuria and hematomas, increase in the period of bleedings;
• Acetylsalicylic acid – reduces plasma concentration of an ibuprofen;
• Magnesium hydroxide – increases initial absorption of an ibuprofen in digestive tract;
• Glucocorticosteroids – increase probability of development of side effects from the alimentary system.

Terms and storage conditions

To store in the protected from light, dry place at a temperature from 15 to 30 °C. To protect from children.

Period of validity – 3 years.