Энзикс

Энзикс – the combined medicine of anti-hypertensive action. Reviews of Enziksa confirm its high therapeutic effectiveness and speed.

Berlipril, Co-renitek, Enalozid, Enapril, Enap – Enziks's drugs analogs.

Structure and form of release of Enziks

Drug of Enziks is produced in the form of tablets. One pack of Enziks contains two medicines – Indapamid (diuretic) and Enalapril (APF inhibitor).

The drug Enalapril contains maleateenalapril (active agent) and auxiliary components – magnesium stearate, magnesium carbonate, gelatin, кросповидон, monohydrate of lactose.

Medicine Indapamid contains индапамид, active agent, and auxiliary ingredients – a macrogoal 6000, talc, titanium dioxide, a gipromelloza, with теарат magnesium, sodium lauryl sulfate, моногидрад lactoses, K30 povidone, кросповидон.

In the instruction to Enziks it is said that one-time use of Enalapril and Indapamid strengthens mutual anti-hypertensive action of Enziks.

Pharmacological action of Enziks

Effect of Enalapril as a part of Enziks promotes decrease in maintenance of Aldosteronum due to suppression of transformation of angiotensin of the 1st group to angiotensin of the 2nd group. Thanks to it the peripheric resistance of vessels, diastolic and average the ABP, an afterload and preload of a myocardium decreases.

Enalapril strengthens a coronary and renal blood stream, increases formation of prostaglandins, renders poorly expressed diuretic effect.

Reduction of indicators of arterial pressure in medical limits does not influence cerebral circulation. The blood stream of vessels of a brain against the background of reduced indicators of pressure is supported at the sufficient level.

In many responses to Enziks the fact that prolonged use of Enalapril promotes reduction of a hypertrophy of a myocardium of a left ventricle is confirmed, and also myocytes of walls of arteries of resistant type due to blood circulation improvement therefore progressing of heart failure is prevented and process of dilatation of a left ventricle is suppressed.

The hypotensive effect of Enalapril is shown in an hour after administration of drug inside, reaches a maximum in four-six hours and remains about days. A drug elimination half-life – 11-12 hours.

Indapamid – hypotensive drug, tiazidopodobny diuretic with long on duration and the action moderated on force, derivative benzamides. It reduces a tone of unstriated muscles of arteries, reduces the general peripheric resistance of vessels. Has moderate diuretic and saluretichesky effects which are shown in blockade of a reabsorption of ions of chlorine, sodium, hydrogen, and also potassium ions in the cortical site of a distal tubule and proximal tubules of nephron. Indapamid reduces a hypertrophy of a left ventricle of heart. In medical doses does not influence carbohydrate and lipidic exchanges. The anti-hypertensive effect reaches the peak in a week at regular reception of a medicine and is supported within a day in case of a single dose. The maximum concentration of Indapamid in plasma is reached in one-two hours after administration of drug. Indapamid elimination half-life – 14-16 hours.

Indications to Enziks's use

According to the instruction of Enziks it is recommended to accept at arterial hypertension.

The instruction to use

According to the instruction to Enziks it is necessary to take one tablet of Indapamid and one pill of Enalapril at the same time once a day.

Depending on change of indicators of arterial pressure the dose of Enalapril can be increased to two times a day.

Contraindications to Enziks's use

Enziks's contraindications are considered on the basis of contraindications of two drugs entering it – Enalapril and Indapamid.

Contraindications to Indapamid's use:

• the expressed renal and/or liver failure;
• hypopotassemia;
• anury;
• children's and teenage age up to 18 years;
• pregnancy;
• hypersensitivity to Indapamid;
• lactation period.

With care use drug at a diabetes mellitus and a hyperuricemia.

Contraindications to Enalapril use:

• renal failure;
• Quincke's disease in the anamnesis;
• гиперчувствительностьк to Enalapril;
• children's and teenage age up to 18 years;
• lactation period;
• pregnancy.

With care of Enziks appoint to patients of old age, and also patients with the following diseases:

• liver and/or renal failure;
• diabetes mellitus;
• cerebrovascular diseases;
• coronary heart disease;
• general diseases of connecting fabric;
• mitral stenosis;
• aortal stenosis and idiopathic hypertrophic subaortal stenosis;
• hyperpotassemia;
• primary hyper aldosteronism.

Side effect of drug of Enziks

Judging by responses to Enziks, this drug at prolonged use quite often makes sick, dryness in a mouth, a sonitus, a vision disorder and hearing, a gastralgia, diarrhea or a lock, allergic reactions, heartbeat, decrease in a libido, sleeplessness, water and electrolytic disturbances, a depression, dizziness, a headache.

In the instruction to Enziks it is said that very seldom prolonged use of medicine leads to development of a myocardial infarction, cough, pharyngitis, sinusitis, muscular spasms, and also promotes emergence of drowsiness, general weakness, an indisposition, increased fatigue.

Medicinal interaction

One-time use of Enalapril and NPVS, analgetics antipyretics reduces efficiency of drug.

The anti-hypertensive effect of Enalapril is strengthened by beta adrenoblockers, diuretics, nitrates, Prazozinum and гидралазин.

Combined use of Enalapril with kaliysberegayushchy diuretics (amiloride, Spironolactonum, Triamterenum), and also with kaliysoderzhashchy means strengthens risk of development of a hyperpotassemia.

Enalapril weakens effect of teofillinsoderzhashchy medicines. Immunodepressants strengthen a means gematotoksichnost.

Combined use of Indapamid and saluretics, cardiac glycosides, glyuko-and mineralokortikoid, tetrakozaktid, purgatives increases risk of development of a hypopotassemia.

Indapamid promotes increase in concentration of lithium in a blood plasma.

Baclofenum strengthens hypotensive action of Indapamid.

One-time use of Indapamid and APF inhibitors quite often leads to development of arterial hypotension.

Combined use of Indapamid and yodosoderzhashchy drugs in the raised doses increases risk of development of a renal failure.

Antipsychotic drugs and tricyclic antidepressants strengthen hypotensive effect of Indapamid.

Enziks storage conditions

According to the instruction of Enziks it is necessary to store in the dry place at a temperature from 20 ° up to 25 °C.

Period of storage – 3 years.