Erius-sorbitol syrup excipients, propylene glycol, anhydrous citric acid, sodium benzoate, citrate sodium a dihydrate, динатрияэдетат, fragrance No. 15864, sucrose, dye, the water purified.

Pharmacological action

Erius is antihistamine – the drug which is carrying out blockade of histamine receptors in an organism that leads to braking of allergic reactions. Active ingredient of Erius selectively affects the neurotransmitters exerting impact on blisteral and hyperemic reaction of skin, an itch, etc. without getting through a blood-brain barrier. By researches it is proved that Erius's use is capable to suppress the following reactions of an organism:

Production of pro-inflammatory chemokines and cytokines;
Adhesion of eosinophilic granulocytes and chemotaxis;
IgE-dependent allocation of a histamine, D2 prostaglandin and C4 leukotriene;
Increase in adhesiveness of R-selectin;
Development of acute bronkhospazmaatopichesky character (in experiments with participation of animals).

Drug possesses antipruritic, antiallergic and antiexudative actions, preventing emergence and facilitating the course of allergic reactions. Erius effectively removes spasms of smooth muscles and prevents emergence of hypostasis of fabrics.

Responses to Erius do not note emergence of the expressed sedative (calming) effect. Besides, clinical trials showed that Erius's reception in a dosage of 20 mg/day for 2 weeks does not exert significant impact on work of cardiovascular system. Unlike other antihistamines Erius's efficiency is not influenced by the use of greasy food or grapefruit juice.

Indications to Erius's use

According to the instruction Erius is effective concerning such diseases as:

Allergic rhinitis (including intermittent and persistent);
Pollinosis, intending for bystry stopping (elimination of the painful phenomena) of an itch in eyes, sneezing, dacryagogue, cough, a rhinedema, a conjunctiva hyperemia;
Chronic idiopathic small tortoiseshell.

Contraindications

Erius's use is undesirable to the persons having hypersensitivity to the dezloratadin and other components which are a part of drug. Besides, Erius's reception at inborn intolerance of fructose, existence of the diseases connected with disturbance of absorption of a galactose or glucose is not recommended – in connection with presence of these substances as a part of syrup Erius.

At the moment the profile of safety of Erius for pregnant women is not established therefore medicine reception by the women expecting a baby is not recommended. It is clinically revealed that active ingredient of drug gets into breast milk therefore feeding by a breast during Erius's reception needs to be stopped.

With care Erius's use should be carried out to the patients having a heavy renal failure.

Side effects of Erius

Таблетки Эриус Refer increased fatigue, dryness in a mouth to side effects of Erius and analogs of means, a headache, tachycardia, allergic reactions (an acute anaphylaxis, rash), hepatitis, increase in activity of liver enzymes, increase in bilirubin in blood. In responses to Erius at administration of drug by children up to 2 years cases of sleeplessness, diarrhea and fever were noted.

Erius route of administration

The optimum dosage of Erius according to the instruction for adults and teenagers from 12 years makes 5 mg a day. The tablet is not recommended to be broken, medicine is accepted entirely, washing down with a small amount of liquid. A dosage for children of 2-5 years: 2,5 ml of syrup, for children of 6-11 years: 5 ml of syrup.

Overdose

In a case exceeding of a dosage of drug is recommended to carry out standard actions for removal of a dezloratadin from digestive tract (reception of absorbent carbon, a gastric lavage) and to carry out symptomatic therapy. Drug is not removed by means of a hemodialysis. On a research of specialists, the overdose of means by 9 times does not exert a serious negative impact on an organism.