Юнидокс

Юнидокс is the antibacterial drug belonging to group of tetracyclines. Its active ingredient is Doxycycline.

Yunidoks's analogs

Юнидокс is issued as well under other names. Yunidoks's analogs are: Doksidar, Apodoksi, Monoklin, Doksal, Ksedotsin, Vibramitsil, Doksibene, Vidoktsin, Bassada, Doksitsiklin, Dovitsil, etc.

Pharmacological action

Юнидокс represents the semi-synthetic tetracycline of a broad spectrum of activity possessing bacteriostatic action. Drug is capable to make impact on the activators located in a cell. According to reviews to Yunidoks microorganisms have high sensitivity gram-positive (staphylococcus, a streptococcus, a clostridium, a listeriya) and gram-negative (a neysseriya, a hemophilic stick, a klebsiyella, colibacillus, a shigella, an enterobakter, a salmonella, an iyersiniya, a treponema). Drug is inactive concerning mushrooms and the majority of strains of a pyocyanic stick and a protea. In the instruction to Yunidoks it is noted that this medicine in comparison with other tetracyclines possesses longer action and higher therapeutic activity.

Indications to Yunidoks's use

According to the instruction of Yunidoks use for treatment of infectious and inflammatory diseases which development is caused by microbes, sensitive to this means:

• Respiratory infections (upper and lower);
• Infections of ENT organs;
• Urinogenital infections;
• Infections of digestive tract and biliary tract;
• Infections of integuments and soft tissues;
• Infectious damages of eyes;
• Iyersinioz;
• Frambeziya;
• Syphilis;
• Ku's fever;
• Legionellosis;
• Clamidiosis;
• Rickettsiosis;
• Fever of the Rocky Mountains;
• Lyme's disease;
• Returnable, tick-borne or sapropyra;
• Amoebic and bacillar dysentery;
• Cholera;
• Tularemia;
• Malaria;
• Actinomycosis.

According to the instruction of Yunidoks it can be applied as a part of complex therapy of the following diseases: peritonitis, septic endocarditis, sepsis, osteomyelitis, brucellosis, whooping cough, ornithosis, psittacosis, trachoma, hay fever.

According to Yunidoks it is rather effective for prevention of pyoinflammatory complications in the postoperative period, and also malaria.

Contraindications

• Hypersensitivity to drug;
• Porphyria;
• Leukopenia;
• Heavy liver failure;
• Second and third trimesters of pregnancy;
• Lactation.

According to Yunidoks promotes adjournment in a bone tissue of insoluble complexes of salts of calcium. Therefore this medicine children should not appoint aged younger than 8 years. At a myasthenia contraindicated intravenous administration of drug. Just the same contraindications have also Yunidoks's analogs.

Side effects

According to the instruction of Yunidoks can cause development of various side effects:

• Loss of appetite, vomiting, nausea, disturbances of the act of swallowing (dysphagy), coloenteritis, diarrhea, pseudomembranous colitis;
• Exfoliative dermatitis, pericardis, erythematic and makulopapulezny rash, Quincke's disease, aggravation of a system lupus erythematosus, anaphylactic reactions, photosensitization, small tortoiseshell;
• Damages of a liver;
• Increases in residual nitrogen of urea;
• Decrease in prothrombin activity, thrombocytopenia, neutropenia, eosinophilia, hemolitic anemia;
• Vestibular disturbances, high-quality increase in intracranial pressure;
• Development of candidiasis.

Route of administration of Yunidoks and dose

Юнидокс it is necessary to accept inside during food, washing down with rather large amount of water. To children 8 years and with body weight more than 50 kg are aged more senior, and also to adult patients in the first day appoint 100 mg two times a day, then give drug on 100 mg once a day. The course of treatment makes from 5 to 10 days. At very heavy infection the daily dose throughout all course can be 200 mg.

To children 8 years are aged more senior and with body weight Yunidoks appoint less than 50 kg in the first day at the rate of 4 mg/kg a day, further reduce a dosage twice.

Intravenous administration of Yunidoks is shown at heavy is purulent - septic diseases when there is a need very quickly to create high concentration of antibacterial drug in the patient's blood. As soon as becomes possible, it is necessary to pass to oral administration of Yunidoks.

Release form

Юнидокс is issued in the form of coated tablets, capsules, the lyophilized powder for injections.