Additional substances: starch sodium glycollate, propylene glycol, magnesium stearate, silicon dioxide colloid, the talc purified кросповидон, sodium lauryl sulfate, starch, lactose, polyvinylpirrolidone.

Structure of the cover covering a tablet: methylene dichloride, gidroksipropilmetiltsellyuloz, isopropanol, titanium dioxide.

Indications to use

Ломфлокс – drug for treatment of diseases of infectious and inflammatory character which causative agents are microorganisms, sensitive to drug:

Infections of bones and joints (including chronic osteomyelitis);
Infections of skin and soft tissues;
The infections of urinogenital system including complicated;
Chlamidia, gonococcal and multi-infections (both acute, and chronic);
Infectious cholecystitises and coloenterites;
Average otitis;
Infections of lower parts of respiratory tracts (including exacerbation of pneumonia and chronic bronchitis);
Pulmonary tuberculosis (ostroprogressiruyushchy forms of a disease, bad portability of rifampicin, multiple medicinal resistance of mycobacteria, tuberculosis and the accompanying nonspecific inflammatory processes).

Also Lomfloks is applied to prevention of development of infectious complications when carrying out transurethral surgical interventions.

Contraindications

Epilepsy, cerebral atherosclerosis and other states / diseases with predisposition to spasms;
Age up to 15 years;
Period of pregnancy and lactation;
Hypersensitivity to drug and/or other hinolona.

Route of administration and dosage

Ломфлокс it is necessary to accept inside, washing down with enough liquid. Meal does not influence efficiency of drug.

The standard daily dose makes 400 mg (1 tablet) of 1 times a day. To patients with a renal failure in the first day appoint 400 mg, further – on 200 mg (1/2 tablets) of 1 times a day.

Treatment duration depending on indications:

Infections of uric ways: uncomplicated – 3 days complicated – 10-14 days;
Exacerbation of chronic bronchitis: 7-10 days;
Infections of skin and skin structures: 10-14 days;
Acute uncomplicated gonorrhea: 1-3 days;
The chronic complicated gonorrhea: 7-14 days;
Acute clamidiosis: 14 days;
Recurrent clamidiosis, including the mixed bacterial chlamydial infection: 14-21 days;
Tuberculosis: 28 days (as a part of complex therapy with Pyrazinamidum, an isoniazid, Ethambutolum);
The accompanying infections at tuberculosis: 14-21 days.

For prevention of infections of urinogenital system after transurethral operation and complications when carrying out a biopsy of a prostate appoint on 1 tablet in 2-6 hours prior to an operation/research.

Side effects

Cardiovascular system: vasculitis, oppression of cardiopulmonary function;
Respiratory system: hypostasis of a throat and/or lungs;
Digestive tract: morbidity of a mucous membrane of an oral cavity, pseudomembranous colitis;
Urinary system: ischuria, polyuria, intersticial nephrite, renal failure;
Skeletal and muscular system: tendinitis, mialgiya, rupture of sheaves, arthralgia;
Central and peripheral nervous system: headache, вертиго, ataxy, tremor, spasms, frustration of a dream, hallucination, confusion of consciousness, uneasiness, photophobia, depression, diplopia, food faddism;
System of a hemopoiesis: hemolitic anemia, thrombocytopenia;
Liver: hepatitis;
Metabolism: hypoglycemia;
Dermatological and allergic reactions: hyperpegmentation, photosensitization, exfoliative dermatitis, anaphylactic reactions, Quincke's edema, toxic epidermal necrolysis, Stephens-Johnson's syndrome.

Special instructions

During therapy it is necessary to avoid influence of ultraviolet rays. The risk of photochemical reaction can be reduced if to accept drug in the evening days.

Dose adjustment is not required to patients with cirrhosis, but provided that functions of kidneys are not broken.

Ломфлокс can cause disturbances of attention and dizziness therefore extent of restriction on an occasion of driving and performance of potentially dangerous types of the works requiring the high speed of reactions and/or special attention has to be defined in an individual order after drug impact assessment on the patient.

Medicinal interaction

Lomefloksatsin it is contraindicated to appoint in a combination with rifampicin since these drugs are competitive antagonists at the microbic level.

Antiacid means, vitamins, сукральфат and other drugs containing iron, aluminum or magnesium slow down absorption of a lomefloksatsin therefore between their receptions it is necessary to observe at least 2-hour breaks.

Ломфлокс increases activity of peroral anticoagulants, increases toxicity of non-steroidal anti-inflammatory drugs.

Probenetsid slows down renal excretion of a lomefloksatsin.