Metamax.

Metamax. – angioprotektivny means.

Form of release and structure

• Capsules (on 10 pieces in the blister, in packaging 4 blisters);
• Solution for injections (on 5 ml in an ampoule, in packaging of 10 ampoules).

Active ingredient of Metamaks – 3-(2,2,2-trimetilgidraziny) propionate a dihydrate: in 1 capsule – 250 mg, in 1 ml of solution – 100 mg.

Auxiliary component of solution: water for injections.

Excipients of capsules: magnesium stearate, aerosil, potato starch.

Indications to use

• Ischemic disturbances of cerebral circulation;
• Cerebrovascular insufficiency;
• Distsirkulyatorny encephalopathy;
• Dystrophic heart diseases;
• Cardialgias owing to dystrophic changes of a myocardium (as a part of complex therapy);
• Chronic bronchitis, chronic obstructive diseases of lungs, infectious and allergic bronchial asthma (as an immunomodulator as a part of complex therapy);
• The lowered physical effeciency (including at athletes);
• The diseases of eyes connected with pathology of an eyeground or dystrophy of a retina;
• Alcoholism (including stopping of an abstinence syndrome).

Besides, Metamax. is appointed in the postoperative period for the purpose of reduction of duration of the rehabilitation period.

Contraindications

• Organic lesions of the central nervous system;
• Pregnancy;
• Lactation;
• Hypersensitivity to drug.

There is no experience of use of Metamaks in pediatrics.

Route of administration and dosage

The recommended modes of dosing and Metamaks routes of administration depending on indications:

• Intellectual and physical overstrain at adults: on 1 ampoule (500 mg) intravenously 1 time a day or on 1 capsule (250 mg) 4 times a day within 10-14 days. If necessary after 2-3 week breaks the course is repeated;
• Overstrain at athletes: on 2-4 capsules 2 times a day before a training in the first half of day. Duration of use makes 2-3 weeks before competitions and 10-14 days during competitions;
• Unstable stenocardia: on 1-2 ampoules intravenously struyno or intramusculary 1 time a day;
• Chronic coronary heart disease: on 1 capsule 3 times a day within 4 days, further – on 1 capsule 2 times a week on an extent of 1,5 months;
• The dishormonal dystrophy of a myocardium proceeding with a cardialgia: on 1 capsule 2 times a day (in the morning and in the evening) within 12-14 days;
• Alcoholism: on 1 ampoule 2 times a day or on 2 capsules 4 times a day, a course of treatment – 7-10 days;
• Dystrophy of a retina and pathology of vessels of an eyeground: on 0,5 ml of 10% of solution retrobulbarno or subkonjyunktivalno within 10 days;
• Acute phase of disturbance of cerebral circulation: on 1 ampoule intravenously 1 time a day for 2-3 weeks;
• Chronic disturbances of cerebral circulation: on 1 ampoule intramusculary 1 time a day or on 1 capsule 1-3 times a day within 14-21 days;
• Distsirkulyatorny encephalopathy: on 1 capsule 1-3 times a day (it is preferable in the first half of day), a course of treatment – 14-21 days;
• Infectious and allergic bronchial asthma: on 1 capsule a day within 3 weeks.

Side effects

Are in certain cases noted:

• Lowering of arterial pressure;
• Tachycardia;
• Excitement;
• Dyspepsia.

Allergic reactions in the form of a skin itch and rashes are in rare instances possible.

Special instructions

At long therapy it is necessary to control functions of kidneys and a liver.

It is necessary to be careful in case of simultaneous use of beta adrenoblockers, peripheral vazodilatator, nifedipine or nitroglycerine since there is a risk of development of arterial hypotension and tachycardia.

Medicinal interaction

Metamax. strengthens action of koronarodilatator, other anti-hypertensive drugs, beta adrenoblockers, cardiac glycosides, nitroglycerine, nifedipine.

If necessary it is possible to appoint medicine in a combination with bronchial spasmolytics (at bronchial asthma), cardiac glycosides and diuretics (at chronic heart failure).

Metamax. pharmacological it is compatible to anti-anginal, antiarrhytmic, anticoagulating and antiagregantny means.

Terms and storage conditions

To store at a temperature 15-25ºC. Not to subject to influence of moisture and light. To protect from children.

Period of validity – 2 years.