Микожинакс

Микожинакс – the complex medicine intended for topical administration in gynecology.

Form of release and structure

Микожинакс release in the form of vaginal tablets (on 12 pieces in strips from aluminum foil, in a cardboard pack 1 strip).

Is a part of 1 tablet:

• Nystatin – 100 thousand IU (international units);
• Metronidazole – 200 mg;
• Chloramphenicol – 80 mg;
• Dexamethasone acetate – 0,5 mg;
• Excipients, including lactoses monohydrate.

Indications to use

Микожинакс it is applied to treatment of the infectious gynecologic diseases caused by microorganisms, sensitive to its active agents:

• Mecotic vaginitis;
• Mycotic vulvovaginitis;
• Bacterial vaginitis;
• The mixed vaginita caused by drozhzhepodobny mushrooms, anaerobic bacteria, trichomonads.

Besides, drug is appointed during training of patients for gynecologic operative measures.

Contraindications

Absolute:

• Children's age;
• Pregnancy;
• Lactation;
• Individual intolerance of components of Mikozhinaks or other drugs of group of imidazoles.

Relative:

• Serious neurologic illness (both acute, and chronic);
• The progressing or chronic neuropathy.

Route of administration and dosage

Микожинакс it is intended for intravaginalny use. The tablet should be entered as it is possible more deeply in a vagina, previously having moistened with water. Within at least 15-30 minutes after the procedure it is necessary to remain in a prone position.

Usually appoint on 1 tablet of 1 times a day, it is preferable – for the night. Treatment duration in each case is determined by the doctor. The recommended course makes 10 days. Depending on disease severity peroral forms of metronidazole can be in addition appointed.

In case of preparation for surgical intervention of Mikozhinaks apply 5 days to and 5 days after operation.

Side effects

Микожинакс can cause local reactions, such as irritation and an itch of a mucous membrane of a vagina, burning, a colpodynia.

Considering a possibility of system absorption of active agents of drug, it is impossible to exclude probability of development of system side effects:

• Digestive tract and gepatobiliarny system: pain in epigastric or abdominal area, diarrhea, disturbance of a chair, vomiting, a loss of appetite, change of flavoring feelings, inflammatory processes of an oral cavity; in isolated cases – pancreatitis, hepatitis with the phenomena of a cholestasia, an abnormal liver function;
• Central and peripheral nervous system: peripheral touch neuropathy, headache, encephalopathy, dizziness, hallucinations, spasms, psychotic frustration, subacute brain syndrome (nystagmus, tremor, ataxy, dysarthtia, gait disturbances);
• System of blood: thrombocytopenia, agranulocytosis, neutropenia, leukopenia;
• Allergic reactions: pustular rash, skin itch, small tortoiseshell, Quincke's edema, hyperemia of integuments, acute anaphylaxis;
• Others: a diplopia, decrease in visual acuity, coloring of urine in red-brown color, false positive test results of Nelson.

Special instructions

The periods are not the cause for drug withdrawal.

During treatment it is recommended to use means for intimate hygiene with alkaline or neutral pH, and also to wear cotton underwear. It is forbidden to carry out vaginal syringings, to use hygienic tampons, to come into sexual contacts.

At treatment of the vaginitis caused by Trichomonas vaginalis, treatment (along with oral administration of metronidazole) both sexual partners should pass at the same time.

During treatment it is recommended to refrain from control of vehicles and work with potentially dangerous mechanisms.

Medicinal interaction

In case of co-administration of Mikozhinaks with a peroral form of metronidazole it is necessary to control a pattern of peripheral blood.

It is contraindicated to apply metronidazole combined with Disulfiramum (because of risk of development of psychotic reactions).

During treatment it is forbidden to take alcohol and to accept drugs which part alcohol since the probability of development of disulfiramopodobny reaction is high is. The use of alcoholic drinks is allowed not earlier than in 24 hours after introduction of the last vaginal tablet.

In need of simultaneous use of cyclosporine or creatinine it is necessary to control their concentration in a blood plasma.

The patients receiving at the same time peroral anticoagulants should control a prothrombin time and if there is a need, to adjust their dose.

Metronidazole can increase toxicity of drugs of lithium and a fluorouratsil, to increase plasma concentration of cyclosporine and a busulfan, to reduce durability of latex contraceptives (including diaphragms and condoms).

Phenytoinum and phenobarbital can reduce plasma concentration of metronidazole.

Terms and storage conditions

To store at a temperature to 25C.

Period of validity – 3 years.