Nitsergolin

Nitsergolin – drug with vasodilating action.

Form of release and structure

Nitsergolin release in the following dosage forms:

• Lyophilisate for preparation of solution for injections: the white porous weight or powder, inodorous (in glass ampoules on 4 mg, on 5 ampoules in a blister strip packaging, (complete with solvent in ampoules on 5 ml, on 5 ampoules in a blister strip packaging), in a cardboard pack 1 packaging);
• Tablets, coated: white, round, biconvex, on cross section two layers are visible.

Is a part of 1 ampoule:

• Active agent: ницерголин – 4 mg;
• Auxiliary components: tartaric acid – 1,04 mg, monohydrate of lactose (milk sugar) – 30 mg.

Solvent: 0,9% sodium chloride solution.

Is a part of 1 tablet:

• Active agent: ницерголин – 10 mg;
• Auxiliary components: monohydrate of lactose – 70 mg, potato starch – 26,9 mg, colloid silicon dioxide (aerosil) – 2 mg, magnesium stearate – 1,1 mg;
• Cover: sugar (sucrose) – 65,3 mg, povidone – 1,967 mg, hydroxymagnesium carbonate pentahydrate – 2,1 mg, colloid silicon dioxide (aerosil) – 0,13 mg, talc – 0,016 mg, titanium dioxide – 0,37 mg, beeswax – 0,117 mg.

Indications to use

• Disturbances of cerebral circulation (brain ischemia, atherosclerosis of vessels of a brain, thromboembolism and thrombosis of cerebral arteries, psychoorganic syndrome, posttraumatic encephalopathy);
• Vertigo;
• Vascular disorders of the peripheral blood circulatory system (functional and organic);
• Migraine;
• Obliterating endarteritis;
• Arteriopatiya of extremities;
• Raynaud's disease;
• Ischemic neuropathy of an optic nerve;
• Dystrophic diseases of a cornea;
• Diabetic angiopatiya and retinopathy.

Contraindications

Injection solution

• Myocardial infarction;
• The expressed atherosclerosis of peripheral vessels;
• Arterial hypotension;
• Organic lesions of heart;
• Angina of exertion;
• Pregnancy and period of a lactation;
• Hypersensitivity to drug components.

Tablets

• Disturbance of orthostatic regulation;
• Recently postponed myocardial infarction;
• The expressed bradycardia;
• Acute bleeding;
• Glyukozo-galaktozny malabsorption, deficit of isomaltase/invertase, deficit of lactase, intolerance of fructose and lactose;
• Age up to 18 years;
• Hypersensitivity to drug components.

Nitsergolin in the form of tablets it is necessary to apply with care at a hyperuricemia or gout in the anamnesis and/or along with the medicines breaking removal or metabolism of uric acid.

Route of administration and dosage

Injection solution

Appoint intramusculary, intravenously and vnutriarterialno 2 times a day 2-4 mg after preliminary dissolution in the sodium chloride solution enclosed 0,9%.

Vnutriarterialno is applied on 4 mg in 10 ml of normal saline solution of sodium chloride (the drug is administered for 2 minutes).

Intravenously kapelno Nitsergolin enter on 4-8 mg on 100 ml of normal saline solution of sodium chloride (in case of need administration of solution can be repeated several times a day).

Course duration – is not less than 2 months (therapeutic action of Nitsergolin develops gradually).

Tablets

Nitsergolin in tablets accept inside.

The dose and duration of a course are defined by character, disease severity and efficiency of the carried-out therapy. Sometimes it is preferable to begin treatment with parenteral administration then for the supporting treatment it is necessary to pass to Nitsergolin's reception inside.

Average single dose – 10 mg, frequency rate of reception – 3 times a day with observance of identical intervals between receptions. Usually therapy long (up to several months).

At treatment of vascular dementia usually appoint 30 mg 2 times a day, at the same time 1 time in 6 months is recommended to consult with the doctor for confirmation of expediency of continuation of therapy.

At functional disturbances of kidneys (at serumal creatinine ≥ 2 mg/dl) a therapeutic dose of Nitsergolin are recommended to be lowered.

Side effects

During Nitsergolin's use such side effects as can develop: dyspepsia (in the form of nausea, vomiting, diarrhea, abdominal pains), feeling of heat, a dermahemia of the person and an upper half of a trunk, a sleep disorder, stenocardia, lowering of arterial pressure, dizziness, a headache, ergotism symptoms (extremity pain, a cold snap of extremities), allergic reactions, a skin itch.

Also concentration of uric acid in blood can increase, at the same time this effect of a dose and duration of use of Nitsergolin does not depend. As a rule, this disturbance moderately or is easily expressed.

At aggravation of the described side effects, or in cases of development of any other disturbances it is necessary to consult at the doctor.

Special instructions

For prevention of development of orthostatic hypotension after intravenous administration of Nitsergolin the patient needs to be within 10-15 minutes in horizontal position.

Alcohol intake during treatment is not recommended.

Therapeutic doses of Nitsergolin usually influences do not render on arterial pressure, however at an arterial hypertension its perhaps gradual decrease.

Considering character of a basic disease, during therapy it is recommended to be careful at control of motor transport and the performance of work requiring special attention.

Medicinal interaction

Nitsergolin strengthens effects of antipsychotic, anxiolytic and hypotensive drugs.

Nitsergolin's absorption is slowed down by Colestyraminum and antacids.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children, at a temperature: lyophilisate for preparation of solution for injections – to 10 °C, a tablet – to 25 °C.

Period of validity – 3 years.