OKA

OKA – the nonsteroid antiinflammatory and antirheumatic drugs used at treatment of diseases of a musculoskeletal system.

Solution of OKA for topical administration – the dental drug used at treatment of diseases of an oral cavity.

Pharmacological action of OKA

Medicines of OKA oppress synthesis of prostaglandins, thanks to ability to inhibit TsOG-1 and TsOG-2, have febrifugal, antiinflammatory and analgeziruyushchy effect, have antibradikininovy activity, detain release from lizosomalny membranes of enzymes and stabilize them that promotes destruction of fabrics at chronic inflammations, reduce release of cytokines and brake activity of neutrophils.

The solution of OKA intended for treatment of diseases of an oral cavity does not possess antibacterial action.

Form of release of OKA

According to the instruction, OKA, intended for treatment of diseases of a musculoskeletal system, release in a look:

• The white or pale yellow granules for preparation of solution for intake possessing a characteristic smell of mint in 2 g three-layered two-volume bags, in packs cardboard on 12 and 20 pieces. One bag of granules of OKA contains 80 mg of ketoprofen of lizinovy salt, 1,7 g of Mannitolum, 132 mg of sodium of chloride, 3 mg of silicon of dioxide of colloid, 20 mg of ammonium of a glitserat, 20 mg of polyvinylpirrolidone, 15 mg of sodium of saccharinate and 30 mg of fragrance mint;
• White or light yellow rectal suppositories of a torpedo-shaped form, in two strips on 5 pieces, in cardboard packs. 160 mg of ketoprofen of lizinovy salt and 1,64 g of glycerides semi-synthetic are a part of one suppository;
• White or light yellow rectal suppositories for children of a torpedo-shaped form, in two strips on 5 pieces, in cardboard packs. 60 mg of ketoprofen of lizinovy salt and glycerides semi-synthetic are a part of one suppository.

OKA for treatment of diseases of an oral cavity release in the form of transparent solution of the green color possessing a characteristic smell of mint in 150 ml plastic bottles from 2 ml the doser for injection, with a dosing glass, in cardboard packs. One ml of solution of OKA contains 16 mg of ketoprofen of lizinovy salt, 200 mg of a glitserol, 0,05 mg of ethanol, 1,5 mg of methylparahydroxybenzoate, 3 mg of mint fragrance, 0,7 mg of menthol, 2 mg of sodium of saccharinate, 0,16 mg of an antiseptic agent of diamond green, 22 mg of sodium of hydrophosphate and 1 ml of the water purified.

Analogs of OKA

Analogs of OKA on active ingredient are drugs Arketal Romfarm, Ketonal and Flamaks.

Analogs of OKA of solution for treatment of diseases of an oral cavity on active ingredient are not released.

On the mechanism of action and belonging to one pharmacological group carry medicines to analogs of OKA Advil, the INSTANT 400 and Faspik.

Kamistad and Holls Max carry medicines to analogs of OKA of solution for treatment of diseases of an oral cavity on the mechanism of action and belonging to one pharmacological group.

Indications to use of OKA

According to the instruction, OKA solution for treatment of diseases of an oral cavity is appointed at:

• Stomatitis;
• Aftakh;
• Ulitis;
• Chronic periodontosis;
• Glossitis;
• Pharyngitis;
• Tonsillitis;
• Laryngitis.

According to the instruction, OKA in granules it is intended for a symptomatic treatment of inflammatory processes which are followed by pain and fervescence (adults), and also for stopping of postoperative pains and a short-term symptomatic treatment of the inflammatory processes accompanying diseases of a musculoskeletal system and otitis (children are more senior than 6 years).

Suppositories of OKA are intended for system use at an osteoarthrosis, rhematoid and gouty arthritis, a spondylarthritis and inflammatory defeats of circumarticular fabrics for adults, and also for stopping of postoperative pains and short-term symptomatic treatment of the inflammatory processes accompanying diseases of a musculoskeletal system and otitis at children 6 years are more senior.

Route of administration of OKA

According to the instruction, OKA in the form of granules accept in the look dissolved in half of glass of water during meal 80 mg three times a day, and children from 6 to 14 years – on 40 mg three times a day.

OKA solution to treatment of diseases of an oral cavity is applied in the look divorced in half of the glass of drinking water which is applied in a set: adults – two rinsings (1 rinsing – 5 injections) in days, children from 6 to 12 years – one rinsing (2 injections), children are more senior than 12 years – one rinsing (3 injections).

According to the instruction, OKA suppositories are applied rektalno in the look moistened before introduction: adults and children of 14 years – on 1 piece twice or three times a day, patients of advanced age – on 1 piece 1-2 times a day, children from 6 to 12 years with body weight more than 30 kg – on 1 piece one or two times a day, children of 12 years – on 1 piece three times a day.

Contraindications

According to the instruction, OKA in granules and suppositories are contraindicated at aspirinovy asthma, a peptic ulcer of a stomach and duodenum, ulcer colitis in a phase of an aggravation, a disease Krone, a diverticulitis, a chronic renal failure, a round ulcer, disturbance of a blood coagulation and hypersensitivity to drug components. Also OKA in granules is not appointed in the III trimester of pregnancy, in the period of a lactation and to children under 6 years.

With care of OKA in granules and suppositories appoint at arterial hypertension, alcoholism, anemia, alcoholic cirrhosis, bronchial asthma, dehydration, hypostases, a liver failure, sepsis, a diabetes mellitus, tobacco smoking, chronic heart failure, blood diseases, stomatitis, and also in I and II trimesters of pregnancy.

According to the instruction, OKA solution for treatment of diseases of an oral cavity is contraindicated at aspirinovy asthma and hypersensitivity to drug components.

With care solution of OKA is appointed at disturbances of a blood coagulation, a disease Krone, a round ulcer, a peptic ulcer of a stomach and duodenum, ulcer colitis in an aggravation phase, in the III trimester of pregnancy and in the period of a lactation, and also to children under 6 years.

Side effects of OKA

Use of granules and suppositories of OKA causes side effects from various systems of an organism, namely:

• Abdominal pains, duodenitis, diarrhea, increase in level of bilirubin and activity of liver enzymes, esophagitis, gastritis, stomatitis, hepatitis, liver failure and increase in the sizes of a liver (alimentary system);
• Dizzinesses, tremor, вертиго, uneasiness, differences of mood, irritability, hallucinations, vision disorder and febricula (central nervous system);
• Small tortoiseshell, Quincke's disease and anaphylactoid reactions (allergic reactions);
• Erythematic dieback, makulopapulezny rash and itch (dermatological reactions);
• Urodynia, hypostases, cystitis and hamaturia (urinary system);
• Lymphangitis, leukocytosis, thrombocytopenia, increase in the sizes of a spleen, Werlhof's disease and vasculitis (system of a hemopoiesis);
• Bronchospasm, feeling of a spasm of a throat, диспноэ, throat hypostasis, laryngospasm and rhinitis (respiratory system);
• Hypertensia, thorax pain, hypotension, tachycardia, peripheral hypostases and pallor (cardiovascular system).

Use of solution for treatment of diseases of an oral cavity of OKA, according to reviews, causes an itch, burning, an exacerbation of hemorrhoids and weight in anorectal area.