Capsules: gelatinous firm, opaque, size No. 2; the case – white, a lid – red color; capsules contain spherical pellets white with a cream shade or white color (on 7 pieces in blister strip packagings, on 2-4 packagings in a cardboard pack; on 10 pieces in blister strip packagings, on 1-3 packagings in a cardboard pack; on 15 pieces in blister strip packagings, on 1-4 packagings in a cardboard pack);
Capsules kishechnorastvorimy (on 7, 10, 14 or 15 pieces in blister strip packagings, on 1-5, 8 or 10 packagings in a cardboard pack; on 14, 10 or 30 pieces in polymeric banks, after 1 bank in a cardboard pack; on 20, 30, 40, 50, 100 pieces in polymeric containers, on 1, 10 or 20 containers in a cardboard pack).

Is a part of 1 capsule:

Active ingredient: омепразол – 20 mg;
Additional components: titanium dioxide, sodium lauryl sulfate, gelatin, нипагин, нипазол, glycerin, E 129 dye, the purified water.

Kishechnorastvorimy is a part of 1 capsule:

Active ingredient: омепразол – 20 mg;
Additional components: sodium carboxymethylstarch (type A), K-30 povidone, sodium hydroxide, copolymer of ethyl acrylate and methacrylic acid [1:1], titanium dioxide (E171), krupk sugar (starch syrup, sucrose), sodium lauryl sulfate, phosphate sodium dodecahydrate, gipromelloz, triethyl citrate, talc;
Gelatin capsule (case and lid): titanium dioxide (E171), gelatin, water.

Indications to use

Reflux esophagitis;
Pancreas adenoma ulcerogenic (Zollingera-Ellison's syndrome);
Peptic ulcer of a stomach and duodenum;
Stressful ulcers;
The erosive cankers of a stomach and duodenum associated with Helikobakter of a pilora (as a part of complex treatment);
The erosive cankers of a stomach and duodenum connected with reception of non-steroidal anti-inflammatory drugs.

Contraindications

Age up to 18 years (except a peptic ulcer of the 12-perstny gut associated with Helikobakter of a pilora (it is allowed for use to children 4 years are more senior), and a gastroesophageal reflux disease (it is allowed for use to children 2 years, having body weight not less than 20 kg are more senior);
Period of pregnancy and lactation (chest feeding);
Hypersensitivity to drug components.

Route of administration and dosage

Omeprazol accept inside, washing down with water in a small amount. It is impossible to chew the capsule. Does not accord a concomitant use with food on efficiency of drug of influence.

The recommended dosing mode:

Erosive and ulcer esophagitis and aggravation of a peptic ulcer of a stomach: a daily dose – 20-40 mg, course duration – 1-2 months;
Aggravation of a peptic ulcer of a duodenum: a daily dose – 20 mg (if necessary, in resistant cases – to 40 mg), course duration – 14-28 days;
The gastrointestinal tract diseases of erosive and ulcer character connected with reception of non-steroidal anti-inflammatory drugs: a daily dose – 20 mg, course duration – 1-2 months;
Destruction Helikobakter of a pilora (Helicobacter pylori eradikation): a daily dose – 40 mg (in 2 receptions), course duration – 7 days in a combination with antibacterial drugs;
Pancreas adenoma ulcerogenic: the dose is selected on the basis of the initial level of gastric secretion; an average initial daily dose – 60 mg, increase it further to 80-120 mg (in 2 receptions);
Reflux esophagitis (with the antirecurrent purpose): a daily dose – 20 mg, course duration – before half a year;
Peptic ulcer of a stomach and duodenum (with the antirecurrent purpose): a daily dose – 20 mg.

Side effects

The side effects arising during Omeprazol's use usually have reversible character.

In rare instances the following disturbances can be observed:

Allergic reactions: Quincke's disease, acute anaphylaxis, small tortoiseshell, bronchospasm, intersticial nephrite;
Nervous system: depression, headache, dizziness, excitement, sleeplessness, drowsiness, paresthesias, hallucinations; against the background of the serious accompanying somatic illnesses or in the presence of anamnestic data on a serious illness of a liver – encephalopathy;
Alimentary system: stomatitis, a lock or diarrhea, dryness in a mouth, vomiting, nausea, an abdominal pain, a meteorism, taste disturbances, tranzitorny increase in level of liver enzymes in plasma; in the presence of anamnestic data on a serious illness of a liver – functional disturbances of a liver, hepatitis (including with jaundice);
Hemopoietic system: thrombocytopenia, leukopenia; seldom – a pancytopenia, an agranulocytosis;
Skeletal and motive system: mialgiya, muscular weakness, arthralgia;
Skin: itch; seldom – a multiformny erythema, a photosensitization, an alopecia;
Others: gynecomastia, fever, peripheral hypostases, vision disorder, sweating strengthening; seldom when performing long therapy – formation of gastric glandulyarny cysts (high-quality reversible character).

Special instructions

Before Omeprazol's appointment it is necessary to exclude malignant process (in particular at stomach ulcer) as use of drug masks symptoms and can delay statement of the right diagnosis.

If there are difficulties with Omeprazol's proglatyvaniye, the capsule it is possible to open or rassosat and swallow its contents. The pellets which are also contained in the capsule can be mixed with a little acidified liquid, for example, yogurt or juice (the received suspension needs to be used for 30 minutes).

At a liver failure in a heavy current Omeprazol's reception in the dose exceeding 20 mg is not recommended.

Medicinal interaction

Long simultaneous use of 20 mg of Omeprazol a day in a combination with metoprololy, diclofenac, quinidine, caffeine, cyclosporine, theophylline, piroxicam, propranolol, Naproxenum, ethanol, oestradiol, lidocaine does not lead to change of their concentration in plasma.

Interaction with antacids at the combined use is noted.

Omeprazol can influence bioavailability of substances/drugs which absorption depends on value of a hydrogen indicator (рН).