Application instruction:
Polyglucinum – drug with plasma substituting, antishock action.
Polyglucinum produce in the form of solution for infusions 6%: transparent, colourless or with slightly yellowish shade (on 100, 200 or 400 ml in bottles (large bottles) or bottles for blood and blood substitutes; on 100, 200, 250, 400, 500 or 1000 ml in the polyolefin packages (bags)).
Is a part of 1 ml:
When using cardiopulmonary bypasses Polyglucinum is added to perfused liquid.
Absolute:
Relative (Polyglucinum is appointed with care in the presence of the following diseases / states):
The feeding and pregnant women can enter Polyglucinum only after an advantage ratio with possible risk for health of mother and the child.
Polyglucinum is entered in stationary conditions intravenously kapelno. At acute blood losses intra arterial introduction is shown.
Speed and volume of administration of solution establish depending on a condition of the patient, pulse rate, size of arterial pressure, a respiration rate, a hematocrit, coloring of integuments.
It is necessary to begin drug transfusion kapelno. After introduction of the first 10 and subsequent 30 drops it is necessary to interrupt introduction for 3 minutes. In the absence of reaction signs (in the form of increase of pulse, lowering of arterial pressure, a dermahemia, breath difficulty) transfusion is continued.
At the developed shock solution of Polyglucinum is entered intravenously struyno. Average one-time volume – 400-1200 ml (increase up to 2000 ml is possible). At increase in arterial pressure to figures, close to norm, it is reasonable to continue administration of drug by a drop method with a speed of 3-3,5 ml/min. (60-80 caps/min.). Infusions should be carried out, constantly controlling the main indicators of a system hemodynamics. In case of substantial increase of the central venous pressure reduce a dose and rate of administering of Polyglucinum or completely cancel therapy. At the expressed anemization and blood loss more than 500 ml reasonablly combined use with packed red cells transfusion or suspensions of erythrocytes, and also blood, freshly frozen plasma with the maintenance of factors of system of a hemostasis. Use of Polyglucinum does not exclude need of holding other antishock actions (using anesthetics, heart, tonic and hormonal drugs).
When carrying out operations with the purpose of prevention of operational shock, prevention of a thrombogenesis and reduction of a tendency to progressing or development of the IDCS intravenous injection of solution of Polyglucinum produce in 30-60 minutes prior to operational intervention kapelno in a dose 5-10 ml/kg, in cases of falling of arterial pressure pass to jet introduction. At sharp lowering of arterial pressure (it is lower than 60 mm of mercury.) it is recommended to transfer the patient to intra arterial introduction on average volume to 400 ml. Jet and drop administration of drug belongs to effective remedies of prevention of postoperative shock in the postoperative period. To children Polyglucinum is entered of 10-15 ml/kg.
During surgical influence the volume of infusions is defined by the size of operational blood loss (the hematocrit should not go down lower than 0,3).
At burn shock the following scheme of use of Polyglucinum is shown:
Administration of solution of Polyglucinum depending on indications can be combined with the following substances / drugs:
For the purpose of prevention of possible dehydration of fabrics is shown to combine performing infusion with administration of crystalloid solutions (a ratio – 1:2).
Possible side effects: fervescence, a lowering of arterial pressure, increase of pulse, allergic reactions (in the form of a skin itch, urtikarny rashes, a Quincke's edema).
Bystry introduction of large volumes of dextrans can provoke edematization of lungs and an acute left ventricular failure.
Introduction of Polyglucinum by standard methods (prior to a research it is recommended to wash erythrocytes of 0,9% NaCl solution) does not interfere with blood typing and carrying out cross matching. Presence at blood of a dextran can exert impact on results of the fermental methods based on papain. When carrying out researches of content of glucose in blood with use of solutions of acetic and sulfuric acids obtaining concentration of glucose is possible more, than is actually.
Solution of Polyglucinum lowers transparency of blood, and also can lead to change of results of measurement of concentration of protein and bilirubin (blood samples are recommended to be taken before administration of drug).
Drivers of vehicles and patients whose profession demands high concentration of attention should apply Polyglucinum with care.
The combined use of Polyglucinum with other widely applied transfusion means is allowed.
To store in the place, unavailable to children, at a temperature up to 25 °C.
Period of validity – 5 years.
Solution maintains freezing, it can be transported at a temperature up to -10 °C. On condition of preservation of tightness of packaging freezing of Polyglucinum a contraindication to its use is not.
Name of drug
Price
Drugstore
Polyglucinum solution for инф 6% фл 200 ml *, the Biochemist (Saransk)
68 rub.
The most high temperature of a body was recorded at Uilli Jones (USA) who came to hospital with a temperature of 46,5 °C.
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