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Polyoxydoñas

The prices in Internet drugstores:

from 684 rub.

 Лиофилизат для приготовления раствора для инъекций и местного применения ПолиоксидонийPolyoxydoñas – the immunoexcitant increasing resistance of an organism to local and generalized infections.

Form of release and structure

Dosage forms:

  • Lyophilisate for preparation of solution for injections and topical administration: hydroscopic and light-sensitive porous weight from color, yellow to white with a yellow shade (in glass bottles: in a cardboard pack of 5 bottles; in a blister strip packaging of 5 bottles, in a cardboard pack 1 packaging; in a cardboard pack of 5 bottles complete with ampoules (5 pieces) of 0,9% of solution of sodium of chloride);
  • Tablets: a ploskotsilindrichesky form, with a facet, dividing risky on one party and a text "ON" – on another, from yellow with an orange shade till the color, white with a yellow shade, existence of impregnations of brighter coloring is possible (on 10 pieces in a blister strip packaging, in a cardboard pack 1 packaging);
  • Suppositories rectal and vaginal: light yellow color, a torpedo-shaped form, with a slight smell of cocoa butter (on 5 pieces in a blister strip packaging, in a cardboard pack 2 packagings).

Active ingredient of Polioksidoniya – an azoxymeasure bromide (polyoxydoñas):

  • 1 bottle of lyophilisate – 3 mg or 6 mg;
  • 1 tablet – 12 mg;
  • 1 suppository – 6 mg or 12 mg.

Auxiliary components:

  • Lyophilisate: povidone, бетакаротен, Mannitolum;
  • Tablets: lactoses monohydrate, Mannitolum, potato starch, povidone, stearic acid, бетакаротен;
  • Suppositories: бетакаротен, Mannitolum, oil of beans of cocoa, povidone.

Indications to use

Polioksidoniya's use is shown for correction of immune insufficiency.

Lyophilisate for preparation of solution for injections and topical administration
Lyophilisate is used as a part of complex therapy at adults and children 6 months for prevention of the acute respiratory diseases (ARD) and flu are more senior.

Besides, drug is used in complex therapy at adults:

  • Tuberculosis;
  • Aggravation and remission of chronic infectious and inflammatory pathologies in the absence of clinical effect of standard methods of treatment;
  • Chronic and acute forms of bronchial asthma, the pollinosis, atopic dermatitis and other allergic pathologies complicated by a recurrent persistent viral and bacterial infection;
  • Persistent and acute viral and bacterial infections, including urogenital infectious and inflammatory diseases;
  • Oncology (in time himio-and radiation therapy and after it, for the purpose of decrease immunosuppressive, gepato-and nephrotoxic effect of medicines);
  • Pseudorheumatism (against the background of long treatment by immunodepressants);
  • The pseudorheumatism complicated by ORZ;
  • Activation of regenerator processes at fractures of bones, burns, trophic ulcers;
  • Prevention of infectious complications after surgeries.

Complex therapy at children:

  • The acute and chronic inflammatory pathologies caused by causative agents of viral, bacterial, fungal infections (including the acute respiratory viral infections (ARVI), an adenoiditis, sinusitis, rhinitis, a hypertrophy of a pharyngeal almond);
  • The bronchial asthma complicated by chronic infectious pathologies of respiratory tracts;
  • Intestinal dysbiosis (in a combination with specific therapy);
  • Acute allergic, toksiko-allergic states;
  • The atopic dermatitis complicated by a purulent infection;
  • Rehabilitation at frequent and long diseases.

Tablets
Tablets are appointed to patients 12 years for prevention and treatment of the infectious and inflammatory diseases of a bacterial, virus, fungal etiology (in a stage of an aggravation and remission) which are not giving in to standard therapy are more senior.

As a part of complex therapy:

  • Acute and chronic infectious and inflammatory pathologies of a stomatopharynx, upper parts of respiratory tracts, okolonosovy bosoms, middle and inner ear;
  • The bronchial asthma, pollinosis and other diseases of allergic genesis complicated by a recurrent bacterial, viral or fungal infection;
  • Rehabilitation it is long and often ill (more than 4-5 times a year).

Suppositories rectal and vaginal
As a part of complex therapy of patients 6 years are more senior:

  • The chronic recuring infectious and inflammatory diseases in a stage of an aggravation and remission in the absence of clinical effect at standard therapy;
  • Acute viral, bacterial and fungal infections;
  • Urethritis, cystitis, pyelonephritis, prostatitis, salpingo-oophoritis, endomyometritis, colpitis, cervicitis, цервикоз, bacterial vaginosis and other urogenital inflammatory diseases of a virus etiology;
  • Allergic diseases which are complicated by a recurrent viral, bacterial or fungal infection (including a pollinosis, atopic dermatitis, bronchial asthma);
  • Various forms of tuberculosis;
  • Pseudorheumatism (at prolonged treatment by immunodepressants);
  • The pseudorheumatism complicated by ORZ or a SARS;
  • Activation of regenerator processes, including burns, fractures, trophic ulcers;
  • Oncology (during and after beam and/or chemotherapy for the purpose of decrease nefro-and hepatotoxic influence of medicines);
  • Rehabilitation of patients it is long ill with a frequency of 4-5 times in a year.

Besides, Polioksidoniya's use in the form of tablets and suppositories is shown in the form of monotherapy:

  • Prevention of seasonal aggravations of the centers of persistent infections of a stomatopharynx, upper respiratory tracts, okolonosovy bosoms, middle and inner ear;
  • Prevention of a herpes recurrent infection;
  • Prevention of acute respiratory infections (including flu) during the preepidemic period at patients with the lowered immunity;
  • Correction of secondary immunodeficiences which emergence is connected with aging or influence of adverse factors.

Contraindications

Polioksidoniya's use is contraindicated to patients with hypersensitivity to drug components.

With care it is necessary to use an azoxymeasure bromide at treatment of patients with an acute renal failure.

It is impossible to appoint lyophilisate and suppositories during pregnancy and breastfeeding.

With care it is recommended to take a pill at a glucose galactose sprue, deficit of lactase, a lactose intolerance.

Age restrictions:

  • Lyophilisate: up to 6 months – with care;
  • Tablets: up to 12 years;
  • Suppositories: up to 6 years.

Route of administration and dosage

Lyophilisate
Lyophilisate is intended for parenteral (intramuscular (in oil) or intravenous (in/in)), intranasal introduction and sublingual reception at children.

Rules of preparation of solution:

  • Introduction in oil: for adults – to dissolve contents of 1 bottle (6 mg) in 1,5-2 ml of water for injections or 0,9% of solution of sodium of chloride; for children – 3 mg of drug to dissolve in 1 ml 0,9% of solution of sodium of chloride or water for injections;
  • In/in drop introduction: for adults – contents of 1 bottle (6 mg) to dissolve in 2 ml 5% of solution of a dextrose, 0,9% of solution of sodium of chloride, gemodeza-N or a reopoliglyukina then to mix with the chosen solution of 200-400 ml; for children – 3 mg to dissolve in 1,5-2 ml 0,9% of solution of sodium of chloride, gemodeza-N, a reopoliglyukina or 5% of solution of a dextrose, then the received solution to transfer to a bottle from 150-250 ml of the chosen solution;
  • Intranasal introduction: for adults – contents of 1 bottle (6 mg), for children – ½ bottles (3 mg), it is necessary to dissolve in 1 ml 0,9% of solution of sodium of chloride, the distilled or boiled water of room temperature.

One drop of the received solution for intranasal introduction at children contains 0,15 mg a bromide azoxymeasure. This solution is used also for sublingual use, it is possible to store it no more than 7 days in the refrigerator, before use the pipette is heated to room temperature.

Solution for parenteral administration should be prepared before direct use.

The way of introduction and dose are established by the doctor on the basis of clinical indications, taking into account age of the patient.

The recommended dosing for parenteral administration:

  • Acute inflammatory pathologies: the adult – on 6 mg a day within 3 days, then – 1 time in 2 days, only 5-10 injections; to children – from calculation for 0,1 mg on 1 kg of weight of the child a day, the procedure is carried out every other day, all – 5-7 injections;
  • Inflammatory diseases of chronic genesis: the adult – on 6 mg of 1 times a day every other day (5 injections), then – 2 times a week, the course of treatment – is not less than 10 injections; to children – on 0,15 mg on 1 kg of weight every 3 day, a course of treatment – to 10 injections;
  • Tuberculosis: 6-12 mg 2 times a week, a course of treatment – 10-20 injections;
  • Acute and chronic urogenital pathologies: on 6 mg every other day, only 10 injections in a combination from himiopreparata;
  • Chronic recurrent herpes: 6 mg every other day, a therapy course – 10 injections at co-administration of antiviral means, interferon and inductors of synthesis of interferon;
  • The complicated forms of allergic diseases: the adult – on 6 mg of 1 times a day within 2 days, further – every other day, only 5 injections; to children – in oil on 0,1 mg on 1 kg of weight a day in 1-2 days, all – 5 injections in a combination with basic therapy;
  • Acute allergic and toksiko-allergic states (in/in in a combination with antiallergic means): the adult – on 6-12 mg, children – on 0,15 mg on 1 kg of weight;
  • Pseudorheumatism: on 6 mg every other day – 5 injections, then – 2 times a week, in total not less than 10 injections;
  • Chemotherapy at oncological pathologies: on 6-12 mg every other day, the course – is not less than 10 injections, then the frequency of introduction is appointed individually, taking into account portability and duration beam and chemotherapy;
  • Correction of an immunodeficiency after an operational oncotomy, beam and chemotherapy, prevention of an immunodepressive effect: on 6-12 mg 1-2 times a week during the long period.

At an acute renal failure administration of drug it is necessary to appoint no more than 2 weekly.

The recommended dosing for intranasal maintaining:

  • Adults: on 3 drops in each nasal course 3 times a day within 5-10 days;
  • Children: on 1-3 drops in one nasal course 2-4 times a day.

Sublingual reception of solution to children (according to all indications): on 0,15 mg on 1 kg of weight a day within 10 days, and at an intestinal dysbiosis – 10-20 days.

Tablets
Tablets apply sublingual (placing under language before full dissolution) and orally in 20-30 minutes prior to food.

The dose and route of administration are appointed by the doctor on the basis of clinical indications.

The recommended dosing mode for sublingual use:

  • Inflammatory pathologies of a bacterial, virus or fungal etiology of an oral cavity and throat: on 1 piece every 12 hours (2 times a day). A course of treatment – 10-14 days;
  • Severe forms of a fungal or herpes infection of an oral cavity: on 1 piece every 8 hours (3 times a day), within 15 days;
  • Chronic form of sinusitis or otitis: on 1 piece 2 times a day, reception duration – 5-10 days;
  • Adenoid disease: on 1 piece 3 times a day within 10-15 days;
  • Chronic diseases of upper parts of respiratory tracts: 2 times a day, adult – on 2 pieces, teenagers – on 1 piece, a course of treatment – 10-14 days;
  • Prevention during the preepidemic period of acute respiratory infections and flu at the patients who are ill ORZ more than 4 times a year: 2 times a day, adult – on 2 pieces, teenagers – on 1 piece, course duration – 10-15 days.

At treatment of chronic diseases of upper parts of respiratory tracts of a tablet appoint inside 2 times a day in a dose: the adult – on 2 pieces, teenagers – on 1 piece within 10-14 days.

Suppositories
Suppositories on 6 i12 are intended to mg for rectal and intravaginalny administration at adults, on 6 mg – rektalno at children.

The mode of dosing and way of introduction are appointed by the doctor on the basis of clinical indications.

For rectal administration it is necessary to clear intestines previously.

Intravaginalno the drug is administered for the night in a prone position.

Standard scheme of therapy: on 1 suppository a day 3 days in a row, then – every other day, only 10-20 suppositories. In 3-4 months the course of treatment can be repeated.

At chronic immune insufficiency the long maintenance therapy is shown: the adult – in a dose of 12 mg, to children – on 6 mg, 1-2 times a week within 2-12 months (as a part of complex treatment).

The recommended dosing as a part of complex therapy:

  • Chronic infectious and inflammatory diseases: at an acute form – the standard scheme, at remission – on 12 mg in 1-2 days, only 10-15 suppositories;
  • Acute infectious processes, activation of regenerator processes: on 1 suppository of 1 times a day within 10-15 days;
  • Tuberculosis: the standard scheme, in total not less than 15 suppositories, then – on 1 suppository every 3 day within 2-3 months (maintenance therapy);
  • Pseudorheumatism, rehabilitation of patients it is frequent and long ill within a year: on 1 suppository every other day, only 10-15 suppositories;
  • Correction of secondary immunodeficiences: on 1 suppository every 3 day, in total not less than 10 suppositories, a course it is necessary to repeat 2-3 times a year;
  • Oncology (at himio-and radiation therapy): prior to the beginning of a course – on 1 suppository daily 2-3 days, further – individually, depending on duration and character beam and chemotherapy.

Monotherapy:

  • Prevention of seasonal exacerbations of infectious chronic diseases, recurrent herpes infection: every other day – the adult on 6-12 mg, children – on 6 mg, only 10 suppositories;
  • Correction of secondary immunodeficiences, prevention of flu and ORZ: standard scheme;
  • Gynecologic pathologies: standard scheme of therapy (rektalno and intravaginalno).

Side effects

Polioksidoniya's use in the recommended doses according to indications usually does not cause undesirable effects.

Solution of drug can cause at introduction in oil morbidity in the place of an injection.

Special instructions

It is not necessary to exceed the dosing recommended by the doctor and duration of a course of treatment.

For decrease in morbidity at introduction in oil drug it is possible to dissolve in 1 ml 0,25% of solution of Procainum on condition of absence at the patient of hypersensitivity to it.

At in (drop) introduction it is impossible to use the infusion solutions containing a protein for lyophilisate dissolution.

Tablets do not exert impact on ability of the patient to control of vehicles and mechanisms.

Medicinal interaction

Polyoxydoñas it is compatible with antifungal, antiviral, antihistamines, antibiotics, bronchial spasmolytics, glucocorticosteroids, cytostatics, besides, of a tablet – to beta-adrenergic agonists.

Terms and storage conditions

To protect from children.

To store in the protected from light, dry place at a temperature: lyophilisate – 4-8 °C, tablets – 4-25 °C, suppositories – 2-15 °C.

Period of validity – 2 years.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Polyoxydoñas lyophilisate 3 of mg of 5 pieces

684 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Polyoxydoñas лиоф a time for инъ 3 mg фл No. 5 **, Petrovax Pharm of NMTs of Ltd company

686 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Polyoxydoñas of a tablet 12 of mg of 10 pieces

759 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Polyoxydoñas тбл 12 mg No. 10, Petrovax Pharm of NMTs of Ltd company

759 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Polyoxydoñas suppositories 6 of mg of 10 pieces

827 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Polyoxydoñas soup рект / levers 6 of mg No. 10, Petrovax Pharm of NMTs of Ltd company

827 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Polyoxydoñas suppositories 12 of mg of 10 pieces

1009 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC
 
 
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