In an initiation of treatment of arterial hypertension appoint 0,5 mg before going to bed. Gradually the dose is raised, at first to 1 mg 3-4 times a day, and further until it is possible to reach a persistent lowering of arterial pressure (usually on it from 4 to 8 weeks are required). The daily dose, optimum for each patient, can vary within 3-20 mg, makes 6-15 mg more often. The general daily dose is divided into 3-4 receptions.

At purpose of Prazozinum as monodrug it is necessary to consider a possibility of development of tolerance. She is possible in an initiation of treatment (for 3-5 day) or in several months. This phenomenon demands increase in a dose of Prazozinum or additional purpose of diuretics.

At slowly developing or insufficient hypotensive effect in addition appoint other anti-hypertensive drugs or diuretics. In this case the dose of Prazozinum is reduced to 1-2 mg by 3 times a day, add the second drug, and then again gradually raise a dose, selecting the most suitable scheme of therapy.

Duration of use of drug is not limited.

At congestive heart failure appoint on 3-20 mg/days in 3-4 receptions.

The most admissible daily dose for adults makes 20 mg.

Side effects

From the central and peripheral nervous system: headache, weakness, вертиго, frustration of a dream, emotional frustration, hallucinations, uneasiness, perception disturbances, depression, fatigue, paresthesias;
From cardiovascular system: anginous pains, short wind, tachycardia, heartbeat, arterial hypotension (especially orthostatic); at prolonged use – hypostases of the lower extremities; seldom – an orthostatic collapse (is more often after reception of the first dose);
From an urinary system: the speeded-up urination;
From the alimentary system: diarrhea or a lock, nausea, vomiting, dryness in a mouth;
From sense bodys: vision disorder, blackout, hyperemia of a cornea and conjunctiva, sonitus;
Allergic reactions: skin rash, itch;
Others: hyperthermia, nose congestion, hyperhidrosis, arthralgia, nasal bleeding, emergence of antinuclear factors, alopecia, decrease in a potentiality, priapism.

Special instructions

During treatment it is necessary to control constantly the heart rate and arterial pressure, as in a prone position, and standing.

At the patients receiving beta adrenoblockers, sympatholytics and diuretics, the probability of hypotension is higher.

Medicinal interaction

Prazozinum is incompatible with nifedipine. Its action is strengthened by sympatholytics, diuretics, beta adrenoblockers.

At simultaneous use of beta adrenoblockers, inhibitors of an angiotensin-converting enzyme, blockers of calcium channels the risk of development of the expressed arterial hypotension, especially after reception of the first dose of Prazozinum increases.

Vazodilatiruyushchy action of blockers of calcium channels and alpha adrenoblockers can be synergistic or the additive. At simultaneous use of Prazozinum with verapamil development of the expressed arterial hypotension is partially caused by their pharmacokinetic interaction: the maximum concentration increases and total concentration of Prazozinum increases.

Indometacin can reduce effect of Prazozinum.

Prazozinum promotes bystry and substantial increase of level of digoxin in a blood plasma, can change anti-hypertensive action of a clonidine.

The patients receiving propranolol after reception of the first dose of Prazozinum have a risk of development of the expressed arterial hypertension.

Terms and storage conditions

To store at a temperature up to 25 ºС in protected from light, the place, dry and unavailable to children.

Period of validity – 3 years.

Whether you know that:

Average life expectancy of lefthanders is less, than right-handed persons.

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