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Retabolil

Масляный раствор для внутримышечного введения РетаболилRetabolil – drug with anabolic action for system use.

Form of release and structure

Dosage form of production of Retabolil – Solutio oleosa for intramuscular introduction: transparent, chartreuse, with a characteristic smell, has no foreign visible mechanical inclusions (in ampoules on 1 ml, on 1 ampoule in a cardboard pack or on 1 ampoule in planimetric plastic packaging (pallet), on 1 packaging (pallet) in a cardboard pack).

Structure of 1 ml of solution:

  • Active agent: деканоат Nandrolonum – 50 mg;
  • Auxiliary components: isopropyl and benzylic alcohols, sunflower oil.

Indications to use

Retabolil is applied to treatment of diseases at which long use of anabolic means is shown (to avoid complications, administration of drug is possible strictly on medical appointment):

  • Osteoporosis of various etiology;
  • Spinal amyotrophy of Verdniga-Goffman;
  • The disturbance of protein metabolism connected with serious burns, injuries, surgeries, radiation therapy, serious infectious diseases;
  • The progressing muscular dystrophy;
  • Cachexia of various etiology;
  • Diabetic retinopathy;
  • Glomerulonephritis, program hemodialysis at a chronic renal failure;
  • The disseminated breast cancer at women (as a palliative method of therapy).

Perhaps combined use of Retabolil with glucocorticoids, cytostatic and tuberculostatic medicines.

Contraindications

  • Prostate cancer and chest gland at men;
  • Nephrotic syndrome;
  • Chronic/acute prostatitis;
  • Damages of a liver in a heavy current, a liver failure against the background of oncological diseases or metastasises in a liver;
  • Pregnancy and period of a lactation;
  • Hypersensitivity to drug components.

Route of administration and dosage

Retabolil should be entered deeply intramusculary.

Drug is appointed for out-patient and hospitalization.

The doctor defines Retabolil dose individually.

The average adult single dose makes 25-50 mg, the nursery – 0,4 mg/kg of body weight; frequency rate of introduction – each 3-4 weeks.

At myopathies purpose of individual doses is possible. At oncological diseases the adult dose makes 50 mg each 5 days, at a heavy renal failure the same dose is entered weekly.

Side effects

Possible side reactions (at men and women): vomiting, nausea, appetite loss, burning sensation in language, decrease/strengthening of a libido, an acne (in particular at boys of pubertal age and at women), a delay in an organism of sodium/nitrogen/water, hypostases, jaundice, a cholestasia, strengthening of vascularization of integuments, suppression of secretion of a gonadotrophin, a hypercalcemia (in particular at motionless patients and at women at metastasises of a breast cancer).

Also, depending on a sex of the patient, the following disturbances can be observed:

  • Women: virilescence symptoms (in the form of a hirsutism, baldness, irreversible decrease in a timbre of a voice, increase in a clitoris, disturbances of a menstrual cycle, suppression of function of ovaries);
  • Men: frequent erections at pubertal age, suppression of function of testicles, an oligospermatism, a gynecomastia, increase in a penis.

Special instructions

To reach optimum therapeutic effect, during therapy of the patient has to receive adequate amount of mineral substances, vitamins, fats, proteins and carbohydrates with food.

To children and women because of androgenic activity Retabolil can be appointed only in cases if the estimated advantage is higher than possible risk.

Use of high doses of drug at pubertal age can lead to premature closing of regions of growth and suspension of growth.

Retabolil can lead to development of a delay in an organism of sodium and liquid therefore it should be applied with care at arterial hypertension, renal/heart failure, epilepsy, migraine, glaucoma (and also in case of instructions on these diseases in the anamnesis). During therapy it is necessary to exercise careful control of intraocular pressure.

Before purpose of Retabolil, and also during treatment it is necessary to carry out rectal control of the size of a prostate.

In some cases during treatment disturbances of indicators of some functional hepatic trials in this connection monitoring procedure of function of a liver is shown every month are observed.

At a diabetes mellitus Retabolil can lead to increase in tolerance to glucose, reducing thereby the need for insulin / peroral gipoglikemiziruyushchy drugs.

At metastasises of a breast cancer in a bone development of a hypercalcemia is possible. In these cases use of drug is possible only after normalization of level of calcium in blood.

Use of Retabolil for stimulation of athletic qualities is inadmissible as can lead to serious violations.

Medicinal interaction

With care it is necessary to appoint Retabolil in a combination with the following medicines:

  • Gipoglikemiziruyushchy drugs: because of probability of strengthening of their hypoglycemic action;
  • Anticoagulants of indirect action: because of probability of strengthening of their action.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature of 15-30 °C.

Period of validity – 5 years.

Under the influence of cold Retabolil can become muddy. In this case the ampoule with solution before use needs to be heated to dissolution of crystals.

 
 
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