Valz

Valz – the peripheral vazodilatator applied at treatment of diseases of cardiovascular system.

Pharmacological action of Valz

According to the instruction Valz is a peripheral vazodilatator which is a specific blocker of AT1, has hypotensive effect and does not inhibit an angiotensin-converting enzyme.

Release form

According to the instruction Valz produce in the form of oval, biconvex, film coated tablets of yellow color with a text of "V" on the one hand, side risks and risky on the other hand 40 mg and 160 mg and tablets of pink color with a text of "V" on the one hand, side risks and risky on the other hand on 80 mg in strip planimetric packagings. One tablet of Valz contains:

• Valsartana – 40 mg (80 mg or 160 mg);
• Monohydrate lactoses – 21,11 mg (42,22 mg or 84,44 mg);
• K29-32 povidone – 3,6 mg (7,2 mg or 14,4 mg);
• Cellulose microcrystallic – 18 mg (36 mg or 72 mg);
• Croscarmellose sodium – 5,4 mg (10,8 mg or 21,6 mg);
• Talca – 0,9 mg (1,8 mg or 3,6 mg);
• Stearate magnesium – 0,63 mg (1,26 mg or 2,52 mg);
• Silicon of dioxide colloid – 0.36 mg (0,72 mg or 1,44 mg).

The film cover of tablets Valz contains опадрай II 85G32407 yellow – 3,6 mg, 7,2 mg or 14,4 mg, and also:

• Polyvinyl alcohol – 1,584 mg (3,168 mg or 6,336 mg);
• Macrogoal-3350 – 0,444 mg (0,889 mg or 1,778 mg);
• Talca – 0,72 mg (1,44 mg or 2,88 mg);
• Dye of ferrous oxide yellow – 0,128 mg (for 40 mg of tablets of yellow color);
• Dye of ferrous oxide yellow – 0,029 mg and dye of ferrous oxide red – 0,049 mg (for 80 mg of tablets of pink color);
• Dye of ferrous oxide yellow – 0,910 mg and dye of ferrous oxide red – 0,016 mg (for 160 mg of tablets of yellow color);
• Dioxide titanium – 0,598 mg (1,373 mg or 1,976 mg);
• Lecithin – 0,126 mg (0,252 mg or 0,504 mg).

Valz's analogs

Valz's analogs on active ingredient are:

• Diovan;
• Валсафорс;
• Tantordio;
• Valsartan Zentiva;
• Nortivan;
• Valsakor;
• Тарег.

On the mechanism of action and belonging to one pharmacological group carry medicines to Valz's analogs:

• Aprovel;
• Atakand;
• Bloktran;
• Brozaar;
• Vazotenz;
• Zisakar;
• Ibertan;
• Irsar;
• Irbesartan;
• Lozartan;
• Losakor;
• Kandesar;
• Kardomin-Sanovel;
• Kardosal 10;
• Kardosten;
• Karzartan;
• Lakea;
• Lozarel;
• Lotor;
• Lorista;
• Makleodz;
• Mikardis;
• Naviten;
• Praytor;
• Prezartan;
• Renikard;
• Telmisartan-Richter;
• Teveten;
• Firmasta.

Indications to Valz's use

Drug Valz is appointed at arterial hypertension and chronic heart failure. Also Valz is a part of complex therapy and is applied to increase in survival of patients with the acute myocardial infarction complicated both by systolic dysfunction of a left ventricle, and a left ventricular failure.

Valz route of administration

According to the instruction Valz accept inside, washing down with liquid irrespective of meal. The dosage of drug depends on a disease, namely:

• At arterial hypertension the initial dose makes 80 mg with possible increase up to 160 mg for 4 weeks once a day;
• At chronic heart failure the dose makes 40 mg twice a day with gradual increase up to 80 mg;
• At stable indicators of a hemodynamics after the postponed myocardial infarction the dose makes 20 mg twice a day with gradual increase up to 40 mg, 80 mg and 160 mg twice a day;
• At easy and moderate abnormal liver functions without development of a cholestasia the dose makes 80 mg a day.

Contraindications

According to the instruction Valz is contraindicated at pregnancy and in the period of a lactation, to children aged up to 18 years, at the abnormal liver functions connected with impassability of bilious ways, a lactose intolerance, a syndrome of the broken absorption of a galactose and glucose, a galactosemia, a renal failure and hypersensitivity to drug components.

With care Valz appoint at arterial hypotension, a hypertrophic subaortic stenosis, a hyponatremia, a hyperpotassemia, a bilateral stenosis of renal arteries or an artery of the only kidney, a mitral and aortal stenosis, primary hyper aldosteronism, and also at the states which are followed by reduction of volume of the circulating blood.

Side effects

Valz's use according to reviews causes complications from various systems of an organism, namely:

• Bleedings, heart failure, lowering of arterial pressure, orthostatic hypotension and vasculitis (cardiovascular system);
• Cough (respiratory system);
• Diarrhea, abdominal pain and nausea (alimentary system);
• Postural dizziness, syncope, sleeplessness, depression, decrease in a libido, dizziness, neuralgia and headache (central nervous system);
• Vertigo (acoustic organs and labyrinth device);
• Neutropenia and thrombocytopenia (system of a hemopoiesis);
• Dorsodynia, arthritis, myotonia, mialgiya and arthralgia (musculoskeletal system);
• Renal failure and acute renal failure (urinary system);
• Hyperpotassemia (metabolism);
• Decrease in level of hemoglobin and hematocrit, increase in concentration of an urea nitrogen in serum, a giperkreatininemiya, increase in activity of hepatic transaminases and a hyperbilirubinemia (laboratory indicators).

Also Valz's use according to reviews can bring to:

• Serum disease;
• Hypersensitivity;
• To Quincke's disease;
• To skin rash and itch;
• To viral infections;
• To upper respiratory tract infections;
• To pharyngitis;
• To sinusitis;
• To conjunctivitis;
• To rhinitis;
• To gastroenteritis;
• To feeling of fatigue;
• Adynamy;
• To nasal bleedings;
• To hypostases.

In overdose cases Valz's use according to reviews causes a lowering of arterial pressure.

Storage conditions

According to the instruction Valz it is necessary to store in the unavailable to children and protected from light hit dry place, at the room temperature up to 30 °C. The medicine period of storage at observance of recommendations makes 3 years.