Vimovo

Vimovo – the combined means which is relating to non-steroidal anti-inflammatory drugs and being inhibitor of the protonew pump.

Pharmacological action of Vimovo

The cover of tablets of Vimovo contains esomeprazole of magnesium which is released at hit in a stomach immediately and influences decrease in secretion of hydrochloric acid, and the kernel of a tablet contains Naproxenum which is released in a slowed-up way and possesses febrifugal and analgeziruyushchy action.

Form of release of Vimovo

According to the instruction, Vimovo is let out in the form of the oval tablets of yellow color covered with a kishechnorastvorimy film cover, with a black text "500/20" on one of the parties, in plastic bottles with the screwing-up cover, with control of the first opening.

One tablet of Vimovo contains 500 mg of Naproxenum and 22,3 mg of esomeprazole of magnesium of trihydrate, and also:

• 50 mkg of wax karnaubsky;
• 35 mg of a gipromelloza 3 mpas77;
• 2.69 monostearate 40-55 glycerin mg;
• 10.85 mg of a gipromelloza 6 мПас;
• 680 mkg of a gipromelloza 50 мПас;
• 580 mkg ferrous oxide yellow (E172);
• 22 mg of croscarmellose sodium;
• 2.62 silicon mg dioxide colloid;
• 1.38 magnesium mg stearate;
• 5.85 mg of a macrogoal 8000;
• 20 mkg of methylparahydroxybenzoate (E218);
• 4.55 polysorbate 80 mg;
• 11 mg of K90 povidone;
• 6.3 mg of a polydextrose (E1200);
• 10 mkg of a propilparagidroksibenzoat (E216);
• 54.6 mg of suspension of 30%;
• 8.18 triethyl citrate mg;
• 13:26 mg of titanium dioxide.

Ink black – q.s is a part of a cover of a tablet., which consist for 22% of black iron oxide, for 7% of a gipromelloza 6 мПас, for 10% of propylene glycol, for 12% of isopropanol and for 49% of the water purified.

Vimovo's analogs

Analogs of tablets of Vimovo on active ingredient are not released. On the mechanism of action and belonging to one pharmacological group carry to Vimovo's analogs:

• Advil;
• Artrum;
• Algezir Ultra;
• To art fates;
• Bonifen;
• Быструмкапс;
• Deksalgin 25;
• Ibuprofen;
• Ibufenum;
• Ketoprofen;
• INSTANT 400;
• Naproksen-ICN;
• Nurofen asset;
• Nurofen UltraCap;
• OKA;
• Rakstan-Sanovel;
• Terafleks Advans;
• Faspik;
• Fleksen;
• Hayrumat.

Indications to Vimovo's use

According to the instruction, Vimovo is applied to relief of symptoms, caused by a pseudorheumatism, an osteoarthritis and an ankylosing spondylitis, and also appointed to the patients having risk of development of the ulcers of a duodenum and stomach associated with reception of non-steroidal anti-inflammatory drugs.

Contraindications

Vimovo's tablets are contraindicated at:

• Heavy uncontrollable heart failure;
• Heavy liver failure or active diseases of a liver;
• The confirmed hyperpotassemia;
• Instructions in the anamnesis on urticaria, bronchial asthma and allergic reactions at reception of non-steroidal anti-inflammatory drugs;
• Renal failure of heavy degree;
• State after aortocoronary shunting;
• Peptic ulcer of a duodenum or stomach in an aggravation phase;
• Inflammatory diseases of intestines in an aggravation phase;
• Concomitant use with Atazanavir and Nelfinavir;
• Hypersensitivity to drug components;
• Gastrointestinal bleedings, hematencephalon or other bleedings;
• Hypersensitivity to other replaced benzimidazoles.

Also drug is contraindicated in the period of the III trimester of pregnancy and in the period of a lactation, and also at children's and teenage age up to 18 years.

Vimovo route of administration

Vimovo, according to the instruction, is applied inside entirely, without chewing, washing down with water on one tablet twice a day for half an hour before meal. With Vimovo's care appoint at a liver and renal failure of easy and moderate degree.

Medicinal interaction

Vimovo, according to the instruction, is not recommended to be combined with anti-retrovirus drugs, with care drug is used with:

• Acetylsalicylic acid (in small doses);
• Diuretics;
• Selective serotonin reuptake inhibitors;
• Corticosteroids;
• APF inhibitors;
• Lithium drugs;
• Methotrexate;
• Derivatives of sulphonylurea and hydantoin;
• Warfarin;
• Beta adrenoblockers;
• Probenetsid;
• Drugs which absorption depends on stomach pH.

Side effects

According to reviews, Vimovo can cause undesirable effects from digestive tract, namely: nausea, dyspepsia, stomach ache and vomiting.

Also, according to reviews, Vimovo causes locks, diarrhea, dizzinesses, pain in an upper part of a stomach and peripheral hypostasis.

Vimovo storage conditions

According to the instruction, Vimovo needs to store in the unavailable to children and protected from light hit, dry place, at the room temperature up to 30 °C. The drug period of storage at observance of instructions makes two years.