Ambrobene

Ambrobene - mucolytic means which has sekretolitichesky, sekretomotorny and expectorant effect.

Form of release and structure

Ambrobene is made in the following forms:

• Capsules;
• Tablets;
• Solution for injections;
• Solution for inhalations and intake;
• Syrup.

As a part of all forms of drug the operating component is Ambroxol the hydrochloride.

Ambrobene's capsules contain the following excipients:

• Methylhydroxypropyl cellulose;
• MKTs and carboxymethylcellulose of sodium;
• The colloid silicon besieged;
• Triethyl citrate;
• Ferrous oxide (black, yellow, red);
• Gelatin;
• Titanium dioxide.

Capsules are issued in blisters. In one blister – 10 pieces. Packaging contains 1 or 2 blisters.

As auxiliary components in Ambrobene's tablets dioxide high-disperse, corn starch, lactose and magnesium stearate act silicon. In one cardboard packaging 2 blisters on 10 tablets.

Solution for Ambrobene's injections as excipients contains:

• Dinatrium моногидрогенфосфат heptahydrate;
• Monohydrate of citric acid;
• Water for injections;
• Sodium chloride.

Ambrobene's solution for injections is produced in ampoules on 2 ml in a strip packaging. One packaging contains 5 pieces.

Ambrobene's solution for inhalations and intake, except active ingredient, contains the purified water, potassium sorbate and hydrochloric acid. It is on sale in bottles droppers from dark glass on 40 or 100 ml. The measured glass is applied to them.

Ambrobene in the form of syrup contains sorbite liquid, crimson fragrance, the purified water, propylene glycol and saccharin. It is on sale in bottles from dark glass on 100 ml. The measured glass is also applied to them.

Indications to use

According to the instruction, Ambrobene is appointed at the following diseases:

• Pneumonia;
• Chronic and acute bronchitis;
• Bronchoectatic disease;
• Chronic obstructive pulmonary disease, including bronchial asthma with the complicated phlegm otkhozhdeniye;

According to the instruction, Ambrobene can be used and as a part of complex therapy at respiratory a distress syndrome at newborn and premature children for surfactant synthesis stimulation.

Contraindications

The instruction to drug warns that Ambrobene's use should be avoided in the following cases:

• Hypersensitivity;
• Epileptic syndrome;
• Peptic ulcer of a stomach and duodenum;
• Feeding period breast;
• First trimester of pregnancy.

With care Ambrobene is appointed at:

• Serious illness of a liver;
• Renal failures;
• Large volumes of the allocated secret;
• Disturbance of motility of bronchial tubes.

Route of administration and dosage

The route of administration of Ambrobene depends on a release form:

• Capsules (1 capsule – 75 mg of Ambroxol of a hydrochloride). Appoint to children 12 years and the adult in the dose corresponding to 1 capsule in day are more senior;
• Tablets (1 tablet – 30 mg of Ambroxol of a hydrochloride). For adults the scheme of use following: on 1 tablet 3 times a day (the first 2-3 days), then frequency rate of receptions is reduced to 2 times a day, or the single dose decreases to 1/2 tablets with preservation of 3 receptions;
• Solution for Ambrobene's injections (1 ampoule – 15 mg of Ambroxol of a hydrochloride). The adult with frequency rate in 2-3 receptions usually appoint on 1 ampoule, however in hard cases increase in a single dose is possible. The daily dose to children is considered according to the following scheme: 1,2-1,6 mg of Ambroxol of chloride are multiplied by the child's weight in kg. In Ambrobene's instruction the following doses are specified: on 1/2 ampoules to children up to 2 years (2 times a day) and to children from 2 to 5 years (3 times a day), and to children of 5-12 years appoint on 1 ampoule, at frequency rate of use 2-3 times a day. At treatment of a syndrome of suffocation at newborn and premature Ambrobene is appointed in 3-4 receptions, and the daily dose is calculated by multiplication of 10 mg of Ambroxol of a hydrochloride by the child's weight in kg. In hard cases with care the daily dose can be increased by 3 times;
• Ambrobene's solution for inhalations and intake (1 ml contains 7,5 mg of Ambroxol of a hydrochloride). The first 2-3 days the adult appoint drug on 4 ml, at the same time frequency rate of receptions – 3 times, then frequency rate decreases to 2 times with preservation of a single dose, or the dose decreases to 2 ml, but 3 times a day are accepted. To children up to 2 years the single dose equal to 1 ml, it is necessary to give 2 times a day; it is necessary to increase the number of receptions to 3 times with preservation of a single dose to children of 2-5 years; 2-3 times a day are appointed a single dose (2 ml) to children of 5-12 years;
• Ambrobene syrup (5 ml – 15 mg of Ambroxol of a hydrochloride). For convenience of use the measuring glass on which one division corresponds to 1 ml of syrup is applied to drug. For adults the single dose makes 10 ml which the first 2-3 days are accepted in 3 receptions, with the subsequent reduction to 2 times. Also after 2-3 days of treatment reduction of a dose to 5 ml with preservation of triple reception is possible. To children 2 years are younger drug is appointed of 2,5 ml 2 times in laziness, to children of 2-5 years the same dose is appointed 3 times a day, children of 5-12 years should give syrup on 5 ml 2 or 3 times a day.

After Ambrobene's use inside drug begins to work in half an hour, action remains for 6-12 hours.

Ambrobene is allocated with breast milk, gets through hematoencephalic and placental barriers.

Side effects

According to the instruction, Ambrobene can cause the following undesirable reactions of an organism:

• Small tortoiseshell;
• Skin rash;
• Quincke's disease;
• Extremely seldom – allergic contact dermatitis, an acute anaphylaxis;
• Diarrhea;
• Lock;
• Dryness in a mouth;
• Rhinorrhea;
• Headache.

Prolonged use of Ambrobene can make sick, vomiting, a gastralgia. Bystry administration of drug can become the reason of an adynamia, feeling of catalepsy, a lowering of arterial pressure, intensive headache, a hyperthermia, an asthma and a fever.

In case of overdose diarrhea, vomiting, dyspepsia which are eliminated by a gastric lavage or calling of vomiting are possible, reception of fat-containing products can also help.

Special instructions

It is not recommended to combine means with antibechic drugs which complicate removal of a phlegm.

In rare instances Ambrobene's use can cause skin reactions in severe forms (a Lyell's disease and Stephens-Johnson's syndrome). At the changes of mucous membranes or integuments which are observed after administration of drug it is necessary to stop administration of drug and at once to see a doctor.

Analogs

Ambrobene's analogs are the following drugs: Ambrolan; Bronkhoksol; Ambrosan; Deflegmin; Bronkhorus; Ремеброкс; Haliksol; Flavamed.

Terms and storage conditions

Ambrobena needs to store in the dry dark place unavailable to children, at a temperature not above 25 °C.

Drug period of validity - 4 years.