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Amitriptyline – antidepressant with the expressed sedative, antibulemichesky and antiulcerous action.
Amitriptyline is produced in the form of solution and tablets.
Tablets are biconvex, round, yellow color, are covered with a film cover.
Active ingredient as a part of drug is Amitriptylini hydrochloridum. Act as auxiliary components in tablets:
According to the instruction, Amitriptyline is appointed for treatment of depressions of the involutional, reactive, endogenous, medicinal nature, and also depressions against the background of an alcohol abuse, the organic lesions of a brain which are followed by sleep disorders, agitation, uneasiness.
Indications to use of Amitriptyline are:
Amitriptyline is applied also at peptic ulcers of a GIT, to removal of headaches and prevention of migraine.
Use of Amitriptyline is contraindicated at:
It is necessary to swallow of tablets of Amitriptyline, without chewing.
Starting dosage for adults – 25-50 mg, accept drug for the night. For 5-6 days the dosage is increased, brought to 150-200 mg/days, use them in 3 receptions.
In the instruction of Amitriptyline it is specified that the dosage is increased to 300 mg/days if in 2 weeks improvement of a state is not observed. When symptoms of a depression disappeared, it is necessary to reduce a dosage to 50-100 mg/days.
If the condition of the patient does not improve within 3-4 weeks of treatment, further therapy is considered inexpedient.
To elderly patients at insignificant disturbances of a tablet of drug appoint 30-100 mg/days in a dosage, accept them for the night. After improvement of a state patients are allowed to pass 25-50 mg/days to the minimum dosage.
Intravenously or intramusculary means is entered slowly in a dosage of 20-40 mg by 4 times a day. Treatment lasts 6-8 months.
Drug at neurologic pains (including chronic headaches) and for prevention of migraine accept 12,5-100 mg/days in a dosage.
To children of 6-10 years at night enuresis give 10-20 mg of drug a day, for the night, to children of 11-16 years – 25-50 mg/days.
For treatment of a depression to children of 6-12 years Amitriptyline appoint in a dose 10-30 mg or 1-5 mg/kg/days, fractionally.
Use of Amitriptyline can cause deterioration in sight, disturbance of an urination, dryness in a mouth, increase in intraocular pressure, fervescence, a lock, functional intestinal impassability.
Usually all these side effects take place after reduction of the appointed doses or after accustoming of the patient to drug.
Besides, at treatment can be observed by drug:
The antidepressive effect of drug develops in 14-28 days from the moment of the beginning of use.
According to the instruction, Amitriptyline should be taken with caution at:
During treatment Amitriptyline forbids driving of the car and work with potentially dangerous mechanisms demanding high concentration of attention and also alcohol intake.
Analogs of drug are: Amitriptyline Nikomed, Amitriptilin-Grindeks, Apo-Amitriptilin and Vero-Amitriptilin.
Drug needs to be stored in the place, dry, unavailable to children, at a temperature from 15-25 °C.
Period of validity 4 years.
Name of drug
Amitriptyline of a tablet 25 of mg of 50 pieces
Amitriptyline of a tablet 10 of mg of 50 pieces
Amitriptyline тбл 10 mg No. 50, ALSI of CJSC Pharm
Amitriptyline тбл 25 mg No. 50, Nycomed
Amitriptyline Nikomed of a tablet of 25 mg 50 pieces
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