Arifon

Arifon – the medicine rendering diuretic, vasodilating and hypotensive (the reducing pressure) action.

Form of release and structure

Produce Arifon in tablets, film coated (30 pieces in the blister, in a pack cardboard on 1 blister).

1 tablet contains 2,5 mg of active active ingredient – an indapamid.

Act as auxiliary components: povidone, magnesium stearate, lactoses monohydrate, corn starch, talc.

Structure of a film cover: глицерол, macrogoal 6000, magnesium stearate, gipromelloz, sodium lauryl sulfate, titanium dioxide, white beeswax.

Indications to use

Arifon's use is shown at arterial hypertension.

Contraindications

• Hypersensitivity;
• Hypopotassemia;
• Heavy liver failure;
• Lactation period;
• Children's age up to 18 years;
• Lactose intolerance, galactose/glucose absorption disturbance syndrome, galactosemia.

Arifon it is necessary to take with caution at a renal and/or liver failure, disturbance of water and electrolytic exchange, a hyperparathyreosis, a hyperuricemia (especially at an uratny nephrolithiasis or gout), pregnancies.

Route of administration and dosage

It is necessary to take a pill orally, it is desirable in the mornings, at the same time, an initial dose – 1,25-2,5 mg.

If therapy for 4-8 weeks has no desirable effect, it is not necessary to increase a dose (noticeable strengthening it will not yield result, but can lead to growth of the negative accompanying manifestations).

Side effects

Arifon's use can provoke the following negative side effects:

• Cardiovascular system: heartbeat, arrhythmia, changes of an ECG (investigation of a hypopotassemia), orthostatic hypotension;
• Nervous system: drowsiness or sleeplessness, adynamy, nervousness, dizziness, headache, вертиго, increased fatigue, depression, febricula, tension, uneasiness, irritability, spasm of muscles;
• Respiratory organs: rhinitis, sinusitis, pharyngitis, cough;
• Urinogenital system: polyuria, nocturia;
• Alimentary system: diarrhea or a lock, nausea, vomiting, dyspepsia, abdominal pain, anorexia, pancreatitis, hepatic encephalopathy owing to a liver failure;
• Bodies of a hemopoiesis: hemolitic anemia, leukopenia, thrombocytopenia, agranulocytosis, marrow aplasia;
• Immune system: allergic answers (urticaria, skin itch, spotty and papular rash, hemorrhagic vasculitis);
• Another: aggravation of a system lupus erythematosus.

Arifon's reception can become the reason of such laboratory indicators as a hypochloraemia, a hyperuricemia, a hypercalcemia, a hyponatremia, a hypopotassemia, a hyperglycemia, a giperkreatininemiya, increase in an urea nitrogen of blood.

Special instructions

Careful control of content of potassium and creatinine at patients of advanced age, and patients accepting purgatives and/or cardiac glycosides against the background of a hyper aldosteronism is recommended.

Systematic check of concentration of sodium, potassium, magnesium in a blood plasma in order to avoid development of electrolytic disturbances as a result of Arifon's reception is necessary. It is regularly necessary to make tests on pH, concentration of uric acid, residual nitrogen and glucose. Especially carefully it is necessary to control these indicators at cirrhosis, coronary heart disease, to chronic heart failure and patients of advanced age.

At the beginning of therapy by Arifon (on the first week) it is necessary to take surely the first measurement of potassium concentration in blood.

Sick diabetes mellitus, especially in a complex with a hypopotassemia, regular control of concentration of glucose in blood is very important.

The hyperparathyreosis which is not diagnosed earlier can be the cause of the hypercalcemia shown against the background of drug intake.

At first at Arifon's reception careful control of function of kidneys is necessary for timely compensation of loss of water as considerable dehydration can become the reason of development of an acute renal failure (decrease in glomerular filtering).

Arifon's use for athletes can give positive reaction at doping control.

Do not appoint drug to children and teenagers because of unproven safety of use.

Analogs

Arifon's synonyms – drugs in which the main active ingredient is индапамид: Akripamid, Arindap, Indap, Indapamid, Indiur, Lorvas, Retapres, Tenzar, etc.

Analog close to medicine on the influence mechanism: Oxodolinum.

Terms and storage conditions

To store in the place unavailable to children.

Period of validity – 5 years.