Blemarenum

Blemarenum – the combined drug used for dissolution and the prevention of formation of urate stones.

Form of release and structure

Blemarenum is released in shape:

• Sparkling tablets (flat, white), on 20 pieces in plastic tubas;
• Granules (coarse-grained, white) for preparation of solution for intake, in plastic bags on 200 g.

Active agents are a part of sparkling tablets:

• 1197 mg of citric acid;
• 967,5 mg of hydropotassium carbonate;
• 835,5 mg of sodium citrate.

The auxiliary components which are a part of sparkling tablets:

• 115 mg of lactose of monohydrate;
• 105 mg of Mannitolum;
• 35 mg of adipic acid;
• 100 mg of a macrogoal 6000;
• 10 mg of saccharinate of sodium;
• 35 mg of lemon fragrance.

100 g of granules of Blemarenum contain:

• 39,9 g of citric acid;
• 32,25 g of hydropotassium carbonate;
• 27,85 g of sodium citrate.

Note: The indicator paper defining acidity of urine, a control calendar and a measured spoon is included in the package with drug (only with Blemarenum in the form of granules).

Indications to use

According to the instruction, Blemarenum is appointed for:

• Dissolution of the mixed urate and oxalic stones (in cases of maintenance of oxalates less than 25%);
• Dissolution calcium - oxalic and urate stones, and also for the prevention of their education;
• Symptomatic therapy of a porphyria of skin;
• Alkalifying of urine at the patients receiving the cytostatics or medicines increasing removal of uric acid.

Contraindications

Use of Blemarenum is contraindicated at:

• Metabolic alkalosis;
• Chronic and acute renal failure;
• Infections of the urinary tract caused by the microorganisms splitting urea;
• Need of observance of a rigid electrolyte-deficient diet;
• Acidities (pH) of urine higher than 7;
• Hypersensitivity to the components which are a part of medicine.

Route of administration and dosage

Drug in the form of the granulated powder or tablets before intake should be dissolved in 200 ml of tea, fruit juice or alkaline mineral water. The daily dosage of Blemarenum (2-6 tablets or measured spoons that corresponds to 6-18 g of medicine) is evenly distributed during the day and accepted after food.

At correctly picked up dose, рН urine within a day is in range:

• 6,2-7,0 – for dissolution of urate stones;
• 7,5-8,5 – for dissolution of tsistinovy stones;
• 7,2-7,5 – for treatment of a porphyria;
• At least 7,0 – at treatment by cytostatics.

If value of acidity of urine provided below, the dosage has to be increased if above – to lower. Therapy duration usually makes 4-6 months.

Control of efficiency of Blemarenum by means of indicator paper needs to be carried out before reception of each single dose three times a day. At tsistinovy stones and treatment of a porphyria for control of efficiency it is necessary to use special indicator paper with size рН 7,2-9,7.

Side effects

During use of Blemarenum can develop:

• Metabolic alkalosis;
• Hypostases (sodium delay);
• Allergic reactions;
• Dyspepsia.

Special instructions

Blemarenum can be applied against the background of a chronic renal failure which is not followed by a delay of potassium ions.

Patients with a diabetes mellitus can accept drug.

During use of Blemarenum it is necessary to limit reception of the products rich with purine bases and proteins and also it is necessary to drink not less than 1,5-2 liters of liquid.

It is not recommended to exceed a daily dose at dissolution of urate stones as at increase in acidity of urine higher than 7.0 there is a sedimentation of phosphates on urate crystals that complicates their further dissolution.

Analogs

On the action mechanism analogs of Blemarenum are: Gindzhaleling, extract of the Madder tinctorial, Uralit-U, Tratseptin, Urokholesan, Urolesanum.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature not above 25 °C.

Drug period of validity in the form of sparkling tablets – 4 years, in the form of granules – 3 years.