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To Fliksonaza

The prices in Internet drugstores:

from 756 rub.

International name - Flutikazona propionate

Structure and form of release to Fliksonaza

Is issued in the form of the nasal spray dosed in bottles of dark glass, with the portioning device – on 60 and 120 doses.

Pharmacological action and pharmacokinetics

To Fliksonaza is glucocorticosteroid means for intranasal use.Спрей Фликсоназе Lowers products of pro-inflammatory mediators, and biologically active agents. Possesses the expressed antiinflammatory, antiallergenic and antiedematous action. Oppresses proliferation of eosinophils, lymphocytes, macrophages, neutrophils, mast cells. The antiinflammatory effect is reached thanks to interaction to Fliksonaza with receptors of glucocorticosteroids.

Use renders to Fliksonaza the bystry and obviously expressed antiinflammatory effect on a mucous membrane of a nose. Antiallergic results it is shown in 2-4 hours after the first reception. Drug stops the majority of signs of allergic reactions in a nasal cavity: sneezing, a rhinorrhea, an itch, a nose congestion, discomfortable feelings in adnexal bosoms and pressure sense. Also to Fliksonaza deletes unpleasant symptoms in eyes.

Stopping of symptoms or their considerable decrease after a single dose remains for 24 hours. At observance of a dosage drug has no systemic action and does not oppress adrenal system.

At intranasal use of a flutikazon of propionate of 200 mkg, it is impossible to define the maximum concentration of drug in a blood plasma, indications make less than 0.01 mg/ml. Extent of absorption in a mucous membrane of a nasal cavity, and also system absorption is minimum because of low solubility of drug in water because of what the most part of drug as a result is swallowed. Less than one percent of drug get to blood. Linkng with blood proteins – 91%.

Flutikazona propionate is brought by system circulation, generally by metabolism in a liver with the participation of CYP3A4 isoenzyme. Removal happens excretion through intestines in an invariable look and in the form of metabolites.

Indications to use to Fliksonaza

Prescribe Fliksonaza for treatment and prevention of seasonal and year-round allergic rhinitis, including hay fever.

Contraindications

Hypersensitivity to drug components. It is contraindicated to children 4 years are younger.

It is necessary to show care at use to Fliksonaza to patients with herpes and at infections of a nasal cavity and adnexal bosoms of a nose, and also at recently postponed injuries of a nose or a nasal cavity operations.

Dosage and route of administration to Fliksonaza

To Fliksonaza it is applied exclusively intranazalno. The therapeutic effect appears at regular use.

To adults and children 12 years are more senior register 100 mkg in each nostril of 1 times a day, it is desirable in the morning. After reduction of symptoms it is possible to lower a dose to 50 mkg in each nostril. The maximum total dose should not exceed 400 mkg. Patients of old age do not need change of a dosage.

The therapeutic effect of reception to Fliksonaza occurs in 3-4 days from the beginning of therapy.

Use to Fliksonaza for children from 4 years, a dosage on 50 mkg/days in each nostril is possible. The maximum dose, admissible for children, – 200 mkg.

Before use drug is recommended to stir up. For use of drug it is necessary to place a thumb from a bottle bottom, and between index and average fingers to clamp the doser then by longitudinal compression of a bottle, to make injection.

It is recommended to wash out the doser clear warm water each 7 days. For this purpose the doser separates from a bottle, and upon termination of washing is installed into place. It is forbidden to use sharp objects for a doser clearing to Fliksonaza the instruction.

Use order

  • To clean a nose washing or a vysmarkivaniye.
  • To insert a doser tip into one nostril, having blocked at the same time another.
  • To incline slightly the head forward.
  • To bring a bottle with medicine into vertical position.
  • On a breath through a nose to make single pressing.
  • To exhale through a mouth.
  • If the double dose is ordered, to make repeated injection in the same nostril.
  • According to the above-stated points to make injection in the second nostril.
  • To clear a doser tip a pure napkin.
  • To close a doser tip a cap.

Side effects and overdose

On the registered responses to Fliksonaza can cause side effects in a look: dryness in a nasopharynx, feelings of an unpleasant smell and taste, nasal bleeding, burning. Emergence of allergic reactions in the form of skin rash, a face edema and language is possible, the bronchospasm and anaphylactic reactions extremely seldom can be shown. Sometimes gives a headache.

About overdose to Fliksonaza responses are not recorded. Symptoms of chronic or acute overdose were not established.Дозатор Фликсоназе

Intranasal acceptance to Fliksonaza by volunteers within 7 days on 2 mg two times a day did not reveal any influence on functions гипоталамо - pituitary and adrenal system. According to responses to Fliksonaza at more prolonged use, can lead to temporary oppression of function of adrenal glands.

Medicinal interaction to Fliksonaza

Owing to the minimum concentration to Fliksonaza in a blood plasma, clinically significant interaction is almost not possible.

At simultaneous use to Fliksonaza with analogs, for example ritonaviry the being strong inhibitor of an isoenzyme CYP3A4, possibly essential raising of concentration of a flutikazon of propionate in a blood plasma that leads to decrease in concentration of cortisol and can develop all side effects caused by systemic action of corticosteroids.

Pregnancy and lactation

According to the instruction, therapy is not recommended to Fliksonaza for pregnant mothers and also at a lactation. When using Fliksonaza and drug analogs for this category of patients needs to proportion estimated advantage of acceptance of drug for mother and probable risk for a fruit.

Conditions and period of storage

To Fliksonaza it is stored at the room temperature. A period of validity - 2 years.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

To Fliksonaza of naz.spry 50 mkg of 120 doses

756 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

To Fliksonaza аэр. наз. 50mkg/dose 120 doses, GlaxoSmithKline

856 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC
 
 
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