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Flucostat

The prices in Internet drugstores:

from 201 rub.

Flucostat – the antifungal drug which is to triazole derivatives.

Medicine Упаковка Флюкостат (7 капсул) is widely applied to treatment of the damages caused by yeast and drozhzhepodobny mushrooms.

Flucostat is produced in the form of solution for intravenous administration and capsules.

1 ml of solution of medicine contains 2 mg of a flukonazol and excipients (sodium chloride, water for injections).

1 capsule of Flucostat contains 50 or 150 mg of a flukonazol and excipients (corn starch, lactose, silicon dioxide, sodium sulfate, magnesium stearate).

Pharmacological effect of Flucostat

Active ingredient of Flucostat according to the instruction selectively strikes specific activators of the fungal nature – R-450 tsitokhroma, trying to obtain disturbance of synthesis of the sterol which are "construction material" for cellular membranes of a mushroom. The lack of sterol increases permeability of a membrane and, finally, destroys it that leads to death of the activator. The inhibiting effect of Flucostat and analogs of drug appears as well on enzymes of a human body, however, use of Flucostat is not capable to have essential negative effect.

Flukonazol after intravenous administration well gets into liquids and body tissues, at the same time concentration of active ingredient in a blood plasma is directly proportional to a drug dose. At the patients having meningitis of fungal etymology, concentration of a flukonazol in cerebrospinal fluid makes 80% of the content of active ingredient in plasma.

Removal of a flukonazol is carried out, preferential, by kidneys, and, about 80% - in an invariable look.

Indications to Flucostat use

Reception of Flucostat according to the instruction is reasonable in the presence of fungal infections of an organism of various weight, including, primary or secondary immunodeficiency. Solution for intravenous administration is applied to treatment of the patients having the diseases caused by cryptococci (infections of skin, lungs, fabrics, meningitis including) and sort Candida mushrooms (candidiasis of mucous membranes, a kandidemiya, a generalized candidiasis). Solution of Flucostat is effective prophylactic concerning the patients receiving radiation and cytostatic therapy and also as prevention of repeated emergence of a cryptococcosis in people with acquired immunodeficiency syndrome.

Flucostat capsules for peroral introduction can be appointed for therapy of the diseases caused by sort Candida mushrooms, cryptococci, and also other microorganisms having sensitivity to a flukonazol. According to reviews, Flucostat in capsules is widely used for treatment of candidiasis of mucous membranes, an onychomycosis, a cryptococcosis, mycosis of skin, a chromophytosis. Besides, according to the instruction Flucostat can be appointed by the doctor as prophylactic when carrying out surgical interventions.

Use of Flucostat at vaginal candidiasis perhaps on doctor's orders.

Contraindications

Flucostat and analogs of drug are not appointed to the people having intolerance of a flukonazol, lactose and also the patients suffering from a glucose galactose sprue, a galactosemia and insufficiency of lactase.

Reception of Flucostat with care is recommended at disturbance of functions of a liver and kidneys, an alcoholism, when receiving the drugs possessing the expressed hepatotoxic action.

Therapy by medicine during pregnancy is not desirable, use of Flucostat is possible only in the presence of the vital indications. During administration of drug it is necessary to refuse breastfeeding.

Side effects of Flucostat

Flucostat, according to reviews, is well transferred by patients. However, at use of drug there can be risks of the following by-effects:

  • From Упаковка Флюкостат (1 капсула)digestive tract and gepatobiliarny system: nausea, vomiting, disturbances of a chair, change of flavoring feelings, pain in abdominal and epigastric areas, jaundice, a meteorism, гепатонекроз, increase in level of bilirubin and liver enzymes;
  • From a nervous system: dizzinesses, spasms, headache;
  • From cardiovascular system: blinking and trembling of ventricles, lengthening of an interval of Q-T, agranulocytosis, neutropenia, leukopenia, thrombocytopenia;
  • Allergic reactions: small tortoiseshell, Quincke's disease, acute anaphylaxis, Lyell's disease, Stephens-Johnson's syndrome;
  • Others: increase in level of triglycerides and cholesterol in plasma, decrease in level of potassium, baldness.

At the use of the overestimated doses of Flucostat emergence of hallucinations, paranoid behavior is possible. The antidote to medicine does not exist. At overdose the symptomatic treatment is carried out: gastric lavage, purpose of enterosorbentny drugs. For decrease in concentration of active ingredient of Flucostat in a blood plasma carrying out an artificial diuresis and hemodialysis is possible.

Medicinal interaction

Simultaneous use of Flucostat and analogs of drug with astemizoly and terfenadiny is forbidden. In combination with the above-stated substances флуконазол it is capable to change efficiency of coumarinic anticoagulants.

According to reviews to Flucostat, use of drug with derivatives of sulphonylurea increases risks of emergence of a hypoglycemia.

The combined use of Flucostat and tsizaprid provokes emergence of side effects from cardiovascular system.

This instruction to Flucostat is submitted only for the fact-finding purposes. Do not accept drug without recommendation of the doctor.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Flucostat of the capsule 150 of mg of 1 piece

201 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Flucostat капс 150 mg No. 1, Pharmstandard-Leksredstva of joint stock company (Kursk)

204 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Flucostat капс 50 mg No. 7 *, Pharmstandard-Leksredstva of joint stock company (Kursk)

349 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Flucostat of the capsule 50 of mg of 7 pieces

353 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Flucostat of the capsule 150 of mg of 2 pieces

381 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Flucostat капс 150 mg No. 2, Pharmstandard-Leksredstva of joint stock company (Kursk)

412 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC
 
 
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