Griseofulvin
Application instruction:
Griseofulvin – an antifungal antibiotic of a fungistasis.
Form of release and structure
Dosage form – tablets: white with a cream shade, have no smell, bitterish on taste (on 10 pieces in a blister strip packaging, in a cardboard pack 2 packagings).
Active ingredient – griseofulvin, in 1 tablet – 125 mg.
Indications to use
Use of Griseofulvin is shown at treatment of infectious diseases:
- The epidermophitias of brushes and feet caused by Trichophyton interdigitale, Trichophyton rubrum;
- Dermatofitiya of smooth skin, a pilar part of the head and nails, caused by mushrooms, sensitive to means, including a trichophytosis, microsporias and a favus.
Contraindications
- Malignant new growths;
- Abnormal liver function and kidneys;
- Pathology of cerebral circulation, including in the anamnesis;
- Changes of morphological composition of blood;
- Uterine bleedings;
- Porphyria;
- System lupus erythematosus;
- Period of pregnancy and breastfeeding;
- Hypersensitivity to griseofulvin.
Route of administration and dosage
Pill is taken orally, during food, along with 1 teaspoon of vegetable oil.
Dosing is appointed depending on clinical testimonies and age of the patient:
- Microsporia: the adult – to 8 pieces (1000 mg) a day, to children – at the rate of 21-22 mg on 1 kg of weight a day. A pill is recommended to be taken to the first negative mycologic analysis daily. Further treatment takes place in the same dose according to the scheme: 2 weeks accept drug every other day and 2 weeks – with frequency rate 2 times a week;
- Trichophytosis, onychomycosis, favus of a pilar part of the head: the adult patient weighing up to 50 kg – on 5 pieces (625 mg) a day, weighing more than 50 kg – on each 10 kg of weight add on 1 tablet (125 mg). The maximum daily dose – 8 pieces (1000 mg). To children: at treatment of a trichophytosis and favus – appointment is carried out at the rate of 18 mg on 1 kg of weight a day, at onychomycoses – at the rate of 16 mg on 1 kg of weight of the child. Treatment of a trichophytosis and favus is carried out similar to therapy of a microsporia. At onychomycoses a pill is taken according to the following scheme: the first month – every day, the second month – every other day, further, before full replacement of the affected nail healthy – 2 times a week. The general course of treatment has to last not less than 8 months.
Side effects
Use of Griseofulvin can become an origin of such side effects:
- From system of a hemopoiesis: a leukopenia, it is rare – an eosinophilia, a leukocytosis;
- From system of digestion: dyspepsia;
- From a nervous system: dizziness, headache, disorientation;
- Allergic reactions: skin rash, small tortoiseshell.
Special instructions
Throughout the entire period of treatment it is necessary to carry out by Griseofulvin regular (1 time in 10-15 days) control of morphological composition of blood.
Reception of tablets should be combined using outside antifungal means.
At a dermatofitiya of a pilar part of the head it is necessary to wash 2 times a week the head with soap warm water and to shave off hair once a week.
At onychomycoses it is necessary to delete systematically devitalized tissues of the affected nails by means of keratolytic means.
At development of allergic reactions it is necessary to appoint antiallergic therapy, in case of strengthening of allergic processes it is necessary to make drug withdrawal for 3-4 days. After removal of displays of an allergy, administration of drug should be resumed about 1/2 tablets a day, and, gradually raising (within 3-4 days), to bring to a therapeutic dose.
At treatment of children simultaneous use of polyvitamins is recommended.
During Griseofulvin use patients need to abstain from all types of activity which performance demands speed of psychomotor reactions and special attention.
Medicinal interaction
Medicinal interaction of drug is not established.
Terms and storage conditions
To store in the place, dry, unavailable to children.
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