Horagon

Horagon – drug like gonadotrophins, treats group of hormones of a hypothalamus and a hypophysis.

Pharmacological action

Horagon possesses gonadotropic effect and properties of luteinizing hormone that allows it to exert impact on an ovulation and to stimulate formation of estrogen and progesterone at women, and also to influence products of testosterone at men.

Active agent of Horagon is the chorionic gonadotrophin of the person allocated by a placenta and got from urine of pregnant women.

Form of release of Horagon

Horagon is issued in the form of powder for injections with various maintenance of a human chorionic gonadotrophin (HGCh): 1500 ME and 5000 ME. In pharmacy chains it is presented in the form of the ampoules of 1 ml offered complete with solvent. Drug is packed into cardboard packs, each of which contains ampoules in number of three pieces.

Indications to Horagon's use

According to the instruction to Horagon drug should be accepted in the following cases:

• women – for induction have ovulations after stimulation of growth of follicles and for maintenance of function of a yellow body of an ovary at those patients for whom insufficiency of a lyuteinovy phase is diagnosed;

• at men and boys – at a cryptorchism, a puberty delay, a hypogonadotropic hypogonadism (in this case Horagon is recommended to accept together with drugs of menopausal gonadotrophins of the person). Also medicine is applied in diagnosis: at differential diagnostic test of a cryptorchism and anorchism at young men, for assessment of functioning of testicles at a hypogonadotropic hypogonadism before the prolonged stimulating treatment (which also carries the name the functional test of Leydiga).

Contraindications

Medical reviews of Horagona warn about existence of a number of contraindications. Use of drug is not recommended at the following diseases:

• at hormonedependent tumors of the sexual sphere;

• at the menacing hyper stimulation syndrome at women during treatment of infertility within the program of "extracorporal fertilization";

• at integrally caused cryptorchism.

Application instruction of Horagon

The drug is administered intramusculary, at the same time in the instruction to Horagon need of immediate input of medicine after its dissolution in the applied solvent is noted.

Horagon's dosage for women depends on specific goals of treatment and makes: for induction of an ovulation – 5000 or 10000 ME, for the purpose of maintenance of functions of a yellow body – from 1500 to 5000 ME for 3, 6 or 9 days later began ovulations.

For boys and men: to boys from 3 to 6 years at a cryptorchism appoint on 1500 ME once a week. The course of treatment makes 3 weeks (in case of need drug should be accepted together with a gonadotrophin-rileasing hormone). For the purpose of acceleration of puberty at young men accept 1500 ME 2 or 3 times a week for 3 months. At a hypogonadotropic hypogonadism it is necessary to accept from 1500 to 6000 ME of Horagon once a week (in combination with drugs of group of the human menopausal gonadotrophins (HMG)). For the purpose of carrying out differential diagnosis of an anorchism and a cryptorchism at boys, and also for assessment of functioning of testicles at a hypogonadotropic hypogonadism Horagon accept in number of 5000 ME once.

Side effects of Horagon

Use of drug is capable to cause emergence of side effects. According to the instruction to Horagon they differ depending on a floor.

At women undesirable reactions in the form of development of a syndrome of hyper stimulation of ovaries are possible. Such effect appears at treatment of infertility using drugs of the ChMG or ChHG group in combination with clomifene. Symptoms of this state are development of cysts of ovaries, ascites, developing of a thrombembolia, accumulation of liquid in a thorax.

At boys and men increase in mammary glands (reversible), and also changes of a proliferative sort in a prostate, a delay of electrolytes and water, emergence of eels in certain cases can be observed. At increase in level of testosterone caused by Horagon's reception the penis size can increase.

Prolonged use of Horagon is fraught with emergence of antibodies which reduce efficiency of treatment.

Overdose

At excess reception of Horagon symptoms of overdose which is shown in the form of hyper stimulation of ovaries are observed. Symptoms differ depending on extent of the excessive use of drug.

• Easy extent of hyper stimulation (1 Art.) does not need treatment. Its symptoms are insignificant increase in the sizes of an ovary, increase in level of sexual steroids, an abdominal pain. In this case the patient needs careful observation;

• 2 stations of hyper stimulation demand treatment which is better for carrying out within hospitalization. As therapy apply introduction in/in solutions to maintenance of OTsK. Emergence of oothecomas is followed by vomiting and nausea;

• At 3 Art. of hyper stimulation there are cysts of ovaries of the large size (more than 10 cm), a hydrothorax, ascites, short wind, an abdominal pain, a delay of salts, increase in viscosity of blood and concentration of hemoglobin. Hospitalization is recommended.

Special instructions

The initiation of treatment of female infertility Horagon has to be preceded by assessment of growth of follicles and a cervical index. In the course of treatment frequent ultrasonic observation, control of level of oestradiol in plasma is necessary.

Hyper stimulation of ovaries is the indication for the therapy termination.

Horagon's reception at insufficiency of a lyuteinovy phase leads to increase in level of progesterone that influences improvement of indicators of an endometria in an embryo attachment phase.

According to medical reviews of Horagona, indications to purpose of drug during normally proceeding pregnancy or in the period of a lactation do not exist.

Horagon storage conditions

Drug is stored at a temperature which is not exceeding 20 °C in the place unavailable to children. Horagon period of validity at observance of all storage conditions equals to 3 years.