Etoksisklerol

Etoksisklerol – means for a sklerozirovaniye of veins.

Pharmacological properties of Etoksisklerol

Is Etoksisklerol's part лауромакрогол 400 which causes a sclerosis of veins. Drug renders anesthesia in an injection site, destroys proteins, at introduction it in a vein is caused by damage of an internal vystilka of vessels – an endothelium. At fall of a vein and contact of its walls with each other there is its sklerozirovaniye, and on site veins there is a fibrous hem. Etoksisklerol is capable to form blood clots which within 7 days will be organized finally.

Positive reviews about Etoksisklerole are received at treatment of hemorrhoids – at administration of drug in a hemorrhoidal node there is his thrombosis to full overgrowing of a gleam of vessels. The drug injection in a wall of a gullet or stomach causes okolososudisty hypostasis in an injection site, growth of cicatricial fabric around vessels and a prelum of varicose veins. The procedure of sclerotherapy is rather painless as drug lowers sensitivity of receptors and transfer of nervous impulses on them.

Release form

Etoksisklerol according to the instruction produce in solution for injections with concentration 0,5%, 1%, 2% and 3%.

Indications to Etoksisklerol's use

Drug is intended for a sklerozirovaniye of hemorrhoidal nodes, telangiectasias, varicose veins of legs, a gullet, for a stop of bleedings using endoscopic tools at ulcer gastromenias or a duodenum.

Contraindications

Etoksisklerol according to the instruction it is impossible to use at his intolerance, in state of shock, at chronic arterial insufficiency or at patients with atherosclerotic narrowing of arteries of extremities, at acute thrombophlebitis, at the requirement to strictly observe a bed rest. It is impossible to apply means at inflammatory changes in heart, during pregnancy, at bronchial asthma.

Application instruction of Etoksisklerol

Drug is intended for intravenous or okolososudisty administration – subepitelialno, submukozno. It is impossible to enter it vnutriarterialno. The patient during the procedure of a sklerozirovaniye has to accept horizontal position, legs are raised at an angle 30 – 45 degrees. Small varicose vessels demand introduction of 0,1 - 0,3 ml of 0,5% - 1% of Etoksisklerol. For average and great defeats it is necessary to enter 0,5 – 1 ml of 2 - 3% of Etoksisklerol, it is most admissible to enter 2 mg/kg/days. Large vessels demand several approaches in a sklerozirovaniye.

For elimination of telangiectasias of peripheral venous vessels the dose of drug is equal to 0,1 - 0,2 ml of 0,5% of solution, the central veins – 0,1 – 0,2 ml of 1% of Etoksisklerol. Apply a compressing bandage in which the patient goes 0,5 hours right after a sklerozirovaniye that the forming fibrous hem was stronger an injection site of drug. At telangiectasias it is necessary to carry a bandage 2 – 3 days, at a varicosity – 5 – 7 days. At a varicosis of legs effective squeezing is reached by use of elastic bandage or medical stockings 2 – 3 classes within 4 – 6 weeks.

In treatment sklerozirovaniy hemorrhoids use 3% Etoksisklerol's solution, at first enter 0,5 – 2 ml, if necessary in 1 – 2 weeks repeatedly enter 3 ml.

For elimination of a varicosity of a stomach or a gullet use 0,5 – 1% solution, enter it paravazalno into a wall of the lower third of a gullet, on a course from 3 to 7 injections, with a break between everyone for 3 – 4 days. The general course dose has to be no more than 4 mg/kg. In case of bleeding from veins of a gullet enter from 5 to 15 ml of 0,5% of Etoksisklerol, a la carte on 1 ml before the termination of bleeding.

Side effects

According to reviews Etoksisklerol has very many undesirable effects – allergic reactions from lungs in the form of dermatitis to a heavy acute anaphylaxis, stenoses or perforation of a gullet, a skin hyperpegmentation over an injection site, nodal fibrosis, pains in the field of an anus, men have a decrease in an erection, bleeding after injections.