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Mifegin – drug for medicamentous interruption of a uterine pregnancy on term up to 42 days and preparation and start of process of childbirth of the full-term pregnancy in case of problems with a fruit.

Таблетки Мифегин предназначены для медикаментозного прерывания беременностиMifegin, active ingredient the mifepristone micronized is an antagonist of sex hormones, increases contractility of a muscular component of walls of a uterus and its tone.

Pharmacological action of Mifegin

Mifegin – the steroid synthetic antigestagenny drug blocking effect of hormone of progesterone at the receptor level is gestagenno inert. Mifepristone counteraction to glucocorticosteroids (GKS) at the level of receptors is noted.

Tablets Mifegin increase sokratitelny ability of a muscular component of walls of a uterus by stimulation of release of the main pro-inflammatory chemokine – Interlaken 8 in horiodetsidualny fabric. Mifepristone increases sensitivity of muscular tissue of a uterus to prostaglandins. To increase effect, along with Mifegin appoint a course of synthetic analogs of prostaglandin. Scaly flaking of an amniotic cover and loss (ekspulsiya) of fetal egg results.

Release form

Tablets Mifegin biconvex, light yellow color, on one of the parties the 167B code. Active component – the micronized mifepristone of 200 mg in 1 tablet.

Mifegin's analogs

Analogs of tablets Mifegin on active component – tablets: Agesta, Ginepriston, Ginestril, Zhenale, Miropriston, Mifepreks, Mifepristone, Mifolian, Penkrofton

Analogs Mifegin on the mechanism there is no action yet.

Indications to Mifegin's use

According to the instruction Mifegin is recommended to reception for interruption on early terms (up to 42 days of an amenorrhea) to a uterine pregnancy.

Also, according to the instruction, Mifegin can be appointed for induction and preparation of patrimonial activity in case of pre-natal death of a fruit when it is undesirable to use prostaglandin or oxytocin.


According to Mifegin's instruction on the general indications it is not appointed in a case:

  • Adrenal insufficiency;
  • Acute or chronic renal failure;
  • Acute or chronic liver failure;
  • Porphyrias;
  • Anemias;
  • Disturbances of a hemostasis;
  • Reception of anticoagulants;
  • Long reception of glucocorticoids;
  • Existence of difficult extragenital pathology;
  • Hypersensitivity to any components of drug.

At medicamentous abortion according to the instruction Mifegin do not apply in a case:

  • Suspicions on an extrauterine pregnancy;
  • The pregnancy which is not confirmed with clinical trials;
  • Absence of monthly more than 42 days;
  • If pregnancy occurred after cancellation of hormonal contraceptive drugs or during use of intrauterine contraceptives;
  • Inflammatory diseases of urinogenital system;
  • 35 years, without the permission of the observing therapist are more senior than smoking of women.

At purpose of drug to preparation and start of process of childbirth according to the instruction Mifegin do not apply in a case:

  • Heavy degree of a gestosis, preeclampsia, eclampsia;
  • Premature or postmature fruit;
  • Placental presentations;
  • If the size of a head of a fruit does not correspond to the size of a basin of the woman;
  • Abnormal presentation;
  • Bloody allocations of the obscure etiology from a genital tract.

Chronic obstructive pulmonary diseases, arterial hypertension, chronic heart failure, arrhythmia – diseases at which Mifegin it is necessary to appoint tablets with care.

Route of administration of Mifegin

According to the instruction of a tablet Mifegin are intended for oral administration. It is possible to use drug only in the conditions of the hospital having the license for rendering medical services, the corresponding medical equipment and specially prepared medical personnel.

The scheme of use of tablets Mifegin is defined by the attending physician.

Medicinal interaction of Mifegin

According to the instruction Mifegin it is not necessary to accept along with non-steroidal anti-inflammatory drugs. It is possible to begin reception of these drugs in 8-12 days after mifepristone reception.

Side effects

Мифегин – стероидный синтетический антигестагенный препаратAccording to reviews Mifegin can cause not only the system side reactions connected with mifepristone reception but also undesirable effects directly of performing therapy.

Undesirable system side effects owing to reception of tablets of Mifegin, according to reviews, are shown by the general weakness, a headache, dizziness, nausea, vomiting, the diarrhea raised by temperature, discomfort and pain in the lower part of a stomach.

Side effects from the procedure of treatment at Mifegin's reception, according to reviews, are shown by usually bloody allocations from a genital tract, pains in the bottom of a stomach, inflammatory processes of a uterus and appendages.

Storage conditions

Tablets Mifegin – list A drug. Storage in dry, protected from light, the place, unavailable to children. A period of storage – 3 years of date of production.

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