Instant 400

Instant 400 – the nonsteroid antiinflammatory medicine applied to a symptomatic treatment of feverish states at flu and colds and also for reduction of pains of various etiology.

Pharmacological action MiG 400

MiG which is a part the 400th ibuprofen is derivative propionic acid, having febrifugal, analgeziruyushchy and antiinflammatory effect. Also, like other nonsteroid antiinflammatory medicines, it has antiagregantny activity.

Analgeziruyushchy effect of active component MiG 400 is most expressed is shown at the pains having inflammatory character. At the same time the anesthetizing property of a medicine does not belong to narcotic type.

Release form MiG 400

The instant 400 is released in the form of oval tablets with bilateral risky and the stamping "Е", in blisters on 10 pieces.

MiG 400 (1 tablets) is an ibuprofen in number of 400 mg a part. In addition to active component excipients are a part MiG 400: silicon dioxide colloid, sodium carboxymethylstarch (type A), starch corn, magnesium stearate.

Analogs MiG 400

Analogs MiG 400 on active component are medicines Advil, Bonifen, the Snow-storm, Ibuprom, Deblok, Ibufenum, the Nurofen, Solpafleks and Faspik.

The following drugs belong to analogs MiG 400 on the mechanism of action: Artrozilen, Artrum, Brustan, Naproxenum, Ibuklin, Ketonal, Deksalgin, Ketoprofen, Nalgezin, Vimovo, Rakstan-Sanovel, Flamaks and Nekst.

Indications to use MiG 400

The medicine MiG 400, according to the instruction, is appointed for a symptomatic treatment:

• Migraines;
• Headache;
• Neuralgia;
• Dentagra;
• Menstrual pain;
• Muscular and joint pain;
• Feverish states at flu and catarrhal diseases.

Contraindications

The instant 400 has a number of contraindications. The medicine cannot be applied at:

• To "Aspirinovy triad";
• Erosive peptic ulcers, including a peptic ulcer of a stomach and a 12-perstny gut and a disease Krone;
• Bleedings of various etiology;
• Hemophilia and other disturbances of coagulability of blood, including hypocoagulation;
• Diseases of an optic nerve;
• Pregnancies and during breastfeeding;
• Deficit glyukozo-6-fosfatdegidrogenazy;
• Hypersensitivity in the anamnesis to non-steroidal anti-inflammatory drugs and acetylsalicylic acid;
• Hypersensitivity to the components which are a part MiG 400.

In pediatrics a pill MiG 400 can be taken since twelve years.

Instant 400, poinstruktion, it is necessary to take with caution:

• Against the background of heart failure;
• At advanced age;
• Against the background of cirrhosis with portal hypertensia;
• At arterial hypertension;
• At a nephrotic syndrome;
• At gastritis, enteritis and colitis;
• Against the background of a liver and renal failure;
• At a peptic ulcer of a stomach and a 12-perstny gut;
• Against the background of a hyperbilirubinemia;
• Against the background of diseases of blood of an unknown etiology.

Route of administration MiG 400

The initial dose of a medicine MiG 400, according to the instruction, for adults and children is not younger than twelve-year age makes 800 mg divided in equal doses into 3-4 receptions.

Increase in a daily dosage up to three tablets MiG 400 is in certain cases possible, however it should be lowered to usual after reduction of symptoms.

Against the background of renal failures, heart or a liver the dose MiG 400, according to the instruction, should be reduced.

According to the instruction, MiG 400 it is longer not necessary to take a pill seven days, and also in the raised dosages as it can lead to overdose which is shown as:

• Headache;
• Abdominal pains;
• Acute renal failure;
• Sonitus;
• Vomiting and nausea;
• Bradycardia;
• Metabolic acidosis;
• Drowsiness and block;
• Apnoea;
• Depression;
• Lowering of arterial pressure;
• Coma;
• Fibrillation of auricles;
• Tachycardia.

Medicinal interaction

Efficiency of thiazide diuretics and furosemide can be reduced at simultaneous use about MiG 400 that is connected with a sodium delay.

Combined use of the ibuprofen which is a part MiG 400 with peroral anticoagulants and acetylsalicylic acid is not recommended.

Besides, MiG 400 can reduce efficiency of anti-hypertensive drugs.

The risk of development of nephrotoxic action increases at a combination therapy MiG 400 with takrolimusy.

Side effects

As well as other nonsteroid antiinflammatory medicines, tablets MiG 400 can cause disturbances of various systems of an organism.

Frustration of the alimentary system can be shown by various symptoms among which development of vomiting, abdominal pains, a meteorism, nausea, heartburn, diarrhea, a lock is the most probable. In rare instances the ulceration mucous digestive tract, complicated by bleedings and perforation can be observed. At emergence of symptoms of bleeding in digestive tract MiG 400 should be cancelled. Besides, frustration can be shown as:

• Mouth pain;
• Pancreatitis;
• Irritation or dryness of a mucous oral cavity;
• Aphthous stomatitis;
• Ulceration of a mucous membrane of gums;
• Hepatitis.

Frustration of a nervous system at reception of tablets MiG 400 are most often shown in a look:

• Headache;
• Nervousness and irritability;
• Sleeplessnesses;
• Dizzinesses;
• Psychomotor excitement;
• Uneasiness;
• Depressions;
• Drowsiness;
• Hallucinations;
• Confusion of consciousness.

During therapy by a medicine MiG 400, according to the instruction, treat frustration of other systems of an organism:

• Bronchospasm and asthma (respiratory system);
• Tachycardia, heart failure, increase in arterial pressure (cardiovascular system);
• Toxic damage of an optic nerve, decrease in hearing, illegibility of sight or doubling, ring or sonitus (sense bodys);
• Anemia, agranulocytosis, thrombocytopenia and Werlhof's disease (system of a hemopoiesis);
• Allergic nephrite, acute renal failure, polyuria, nephrotic syndrome, cystitis (urinary system).

Prolonged use of tablets MiG 400 in high doses increases risk of development of bleedings (gastrointestinal, uterine, gingival, hemorrhoidal) and vision disorders.

Against the background of the carried-out treatment a medicine MiG 400 most probable allergic reactions are:

• Bronchospasm or диспноэ;
• Quincke's edema;
• Eosinophilia;
• Skin rash and itch;
• Mnogoformny exudative erythema;
• Acute anaphylaxis;
• Anaphylactoid reactions;
• Fever;
• Toxic epidermal necrolysis;
• Allergic rhinitis.

Storage conditions

The instant 400 treats nonsteroid antiinflammatory medicines of non-prescription dispensing with a period of validity of 36 months at observance of standard storage conditions (at a temperature up to 30 °C).