Nystatin

Nystatin – antifungal antibiotic drug.

Form of release and structure

Nystatin is produced in the following dosage forms:

• Tablets, coated or film cover: light yellow with a greenish shade, with a weak smell of vanillin, on cross section – two layers (on 20 pieces in dark glass jars, plastic containers or polyethylene bottles, after 1 bank, to a container or a bottle in a cardboard pack; on 10, 20 pieces in blister strip packagings, on 1-3, 5 packagings in a cardboard pack);
• Suppositories for rectal use: yellow, torpedo-shaped, with the maximum diameter of 1,2 cm (on 5 pieces in blister strip packagings, on 2 packagings in a cardboard pack);
• Suppositories vaginal: yellow, torpedo-shaped (on 5 pieces in blister strip packagings, on 2 packagings in a cardboard pack);
• Ointment for external use: ocherous or yellow color (on 10, 15, 25 or 30 g in aluminum or polymeric tubas, on 1 tuba in a cardboard pack).

Is a part of 1 tablet:

• Active ingredient: nystatin – 250 000 or 500 000 AU (action units);
• Auxiliary components: milk sugar, liquid paraffin, main carbonic magnesium, oksipropilmetiltsellyuloz (OPMTs), stearate calcium, potato starch, MTs-16 (methyl cellulose), titanium dioxide pigmental, тролеин Oh, twin 80, vanillin.

Rectal is a part of 1 suppository:

• Active ingredient: nystatin – 250 000 or 500 000 AU (action units);
• Auxiliary components: propyl ether of parahydroxybenzoic acid, food citric acid, liquid paraffin, витепсол W-35, витепсол H-15.

Vaginal is a part of 1 suppository:

• Active ingredient: nystatin – 250 000 or 500 000 AU (action units);
• Auxiliary components: propyl ether of parahydroxybenzoic acid, food citric acid, витепсол W-35, витепсол N-15.

Is a part of 1 g of outside ointment:

• Active ingredient: nystatin – 100 000 PIECES;
• Auxiliary components: anhydrous lanolin, medical vaseline.

Indications to use

Tablets and ointment:

• Candidiasis of internals;
• Candidiasis of mucous membranes and skin;
• At long treatment by antimicrobic medicines, in particular the weakened and exhausted patients have a candidiasis (prevention).

Suppositories vaginal:

• Vaginal candidiasis;
• Fungal complications when performing local antimicrobic therapy (prevention).

Suppositories rectal:

• Candidiasis of lower parts of intestines;
• Fungal infections in to - and the postoperative periods (prevention).

Contraindications

• Functional disturbances of a liver;
• Peptic ulcer of a stomach and duodenum;
• Pancreatitis;
• Pregnancy;
• Hypersensitivity to drug components.

Route of administration and dosage

Tablets
Nystatin is accepted inside, irrespective of meal.

At treatment of candidiasis of internals it is recommended to apply the following mode of dosing:

• Adults – 4-8 times a day on 500 000 PIECES (at generalized candidiasis – to 6 000 000 PIECES a day);
• Children of 1-3 years – 3-4 times a day on 250 000 PIECES; children of 3 years – 4 times a day on 250 000-500 000 PIECES.

Course duration – 10-14 days. If necessary in a week the course of treatment can be repeated.

Outside ointment
At treatment of candidiasis of mucous membranes and skin apply ointment on affected areas a thin layer 2 times a day. Treatment should be carried out daily for 7-10 days.

Carrying out a combination therapy with Nystatin in the form of tablets is possible.

Suppositories vaginal
Nystatin should be entered into a vagina after the hygienic procedures.

Single dose – 1 suppository, frequency rate of use – 2 times a day (in morning and evening). Course duration – 10-14 days.

Suppositories rectal
Nystatin is entered deeply into a rectum.

Single dose – 1 suppository, frequency rate of use – 2 times a day (in morning and evening). Course duration – 10-14 days.

If necessary carrying out repeated medical courses is possible.

Side effects

• Alimentary system: vomiting, nausea, diarrhea (for tablets and rectal suppositories);
• Allergic reactions: fever, skin itch, temperature increase;
• Others: there is a probability of distribution of resistant forms of mushrooms that can lead to therapy cancellation.

Special instructions

In cases of development of side effects it is necessary to lower a dose or to cancel therapy.

It is not necessary to interrupt treatment with vaginal suppositories during periods. At fungal diseases of a vagina performing simultaneous treatment of the sexual partner is recommended. During therapy it is necessary to avoid sexual contacts.

Medicinal interaction

At combined use of Nystatin with Clotrimazolum activity of the last goes down.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children.

Period of validity:

• Tablets – 2 years at a temperature of 18-20 °C;
• Suppositories rectal and vaginal – 2 years at a temperature up to 5 °C;
• Ointment for external use – 3 years at a temperature up to 5 °C.