Sanorin

Sanorin – medicine of vasoconstrictive and antikongestivny action for topical administration in otorhinolaryngological practice.

Form of release and structure

Sanorin is produced in the following forms:

• drops nasal 0,05% and 0,1%: in the form of transparent colourless liquid (on 10 ml in bottles droppers of dark glass, in a cardboard pack one bottle);
• spray of nasal 0,1%: in the form of the colourless transparent liquid which does not have a smell and without visible particles (on 10 ml in plastic bottles with the mechanical dosing applicator, in a cardboard pack one bottle).

Structure of 1 ml of drops:

• active ingredient: naphazoline nitrate – 0,5 mg or 1 mg;
• auxiliary components: methylparahydroxybenzoate, boric acid, water, ethylene diamine.

Structure of 1 ml of spray:

• active ingredient: naphazoline nitrate – 1 mg;
• auxiliary components: methylparahydroxybenzoate, boric acid, water, ethylene diamine.

Indications to use

• sinusitis;
• acute rhinitis of various origin;
• laryngitis;
• average otitis (as the additional tool reducing hypostasis of a mucous membrane of a nasopharynx);
• eustachitis;
• nasal bleedings (in need of their stop);
• reduction of hypostasis of mucous membranes of a nasopharynx, nasal cavity and adnexal bosoms during medical and diagnostic procedures.

Contraindications

Absolute:

• atrophic rhinitis;
• chronic rhinitis;
• the expressed atherosclerosis;
• arterial hypertension;
• tachycardia;
• serious illnesses of eyes;
• closed-angle form of glaucoma;
• diabetes mellitus;
• thyrotoxicosis;
• simultaneous use of monoamine oxidase inhibitors and the period up to two weeks after the end of their reception;
• children's age up to two years (Sanorin in the form of drops of nasal 0,05%);
• children's and teenage age up to 15 years (Sanorin in the form of spray and a thaw of nasal 0,1%);
• hypersensitivity to any of drug components.

Relative (Sanorin is applied with care):

• coronary heart disease;
• pheochromocytoma;
• prostate hyperplasia;
• breastfeeding period;
• pregnancy period.

Route of administration and dosage

At sinusitis, acute rhinitis, laryngitis, an eustachitis and for simplification of holding a procedure of a rinoskopiya to adult patients and teenagers 15 years are more senior appoint on 1-3 drops of Sanorin in the form of 0,1% of drops nasal or on 1-3 doses of spray Sanorin in each nostril. Frequency rate of use – 2-3 times a day.

At children and teenagers at the age of 2-15 years nasal 0,05% apply drops. The recommended dose – on 1-2 drops in each nostril 2-3 times a day. The interval between instillations has to be not less than 4 hours.

Sanorin is applied quickly: adult patients have no more than 7 days, children have at most 3 days. At simplification of nasal breath drug can be cancelled earlier. The repeated instillation or injection is possible in several days.

For a stop of nasal bleeding place the cotton plug moistened with solution of the drug Sanorin of 0,05% of Concentration in the nasal course.

Drops nasal 0,05% can be applied as an additional tool at treatment of conjunctivitis of a bacterial origin. For this purpose Sanorin is dug in on 1-2 drops in each conjunctival sac by 3-4 times a day.

Before the first injection of spray it is recommended to press the portioning device several times before emergence of a compact cloudlet of an aerosol. Before use it is necessary to remove a protective cap and, holding a bottle in vertical position, to enter a trailer part of the device into the nasal course, then quickly and to press sharply the applicator. Right after injection to make an easy breath a nose and to close the applicator a protective cap.

Side effects

• alimentary system: nausea (very seldom);
• central nervous system: irritability and headache (very seldom);
• cardiovascular system: increase in arterial pressure and tachycardia (very seldom);
• other reactions: rash, the increased perspiration and allergic reactions (very seldom).

At the increased individual sensitivity there can be local reactions in the form of dryness and burning sensation in a nasal cavity. After the termination of influence hypostasis and a reactive hyperemia of a mucous membrane of a nasal cavity is (in rare instances) possible. At frequent and long (more than one week) use of Sanorin there can be an irritation, a mucosal atrophy of a nasal cavity and chronic disturbance of passability of the nasal courses.

When using in the recommended doses drug, as a rule, is transferred well.

Special instructions

It is necessary to avoid prolonged treatment by Sanorin as at long use the tachyphylaxis phenomenon (decrease in vasoconstrictive effect of drug) is observed. In order to avoid by-effects from nervous and cardiovascular systems it is not necessary to exceed the recommended doses.

Sanorin can have resorptive effect.

Drug with care is appointed to patients before carrying out the general anesthesia by means of anesthetics which increase sensitivity of a myocardium to sympathomimetics (for example, a halothane), especially at patients with bronchial asthma.

Sanorin does not influence ability of the person to manage motor transport and to perform other work connected with the increased concentration of attention and bystry reaction.

Medicinal interaction

Tricyclic antidepressants and monoamine oxidase inhibitors at simultaneous use with naphazoline can cause increase in arterial pressure (the same effect remains within 14 days after their cancellation therefore this combination is contraindicated).

Sanorin slows down absorption of mestnoanesteziruyushchy means that leads to increase in duration of their action.

Terms and storage conditions

To store in the dark place at a temperature of 10-25 °C. To protect from children.

Period of validity – 4 years.

The opened bottle with drug needs to be used within 1 month.