Solian

Solian is a neuroleptic which found application in psychiatric practice.

Pharmacological action of Solian

Solian treats group of antipsychotic drugs. Active active ingredient – амисульпирид. It is selectively tropine (has affinity) to dopamine receptors 2 and 3 types of limbic system of a brain, without influencing at the same time other types of receptors in an organism - serotoninovy, cholinergic, adrenergic, histamine. Thanks to it амисульпирид has the medical effect, without causing many side and undesirable effects which usually meet at stimulation of the listed receptors. Therefore according to reviews Solian is had much better, than a haloperidol and its analogs. The limbic system is a site of a brain which is responsible for emotions. Influencing her receptors, Solian has the calming effect, suppresses aggression and excitement. At the same time reaction to external stimuluses decreases. At mental diseases drug is capable to suppress hallucinations, nonsense, avtomatizm, making positive medical impact on patients.

Solian – antipsychotic drug, atypical, other than other neuroleptics. Medicinal action its dozozavisimy – in high dosages, beginning from 400 mg/days, it blocks postsynaptic receptors and makes positive impact on productive symptomatology of a disease (nonsense, hallucinations). In low dosages (50 – 300 mg/days) Solian unites to presynaptic dopamine receptors thanks to what eliminates negative symptomatology (lack of emotionality, leaving from communication).

Solian according to the instruction has no somnolent effect, but can promote more bystry approach of a dream and sleepiness. Solian according to reviews strengthens action of somnolent, narcotic, mestnoanesteziruyushchy means and reduces effect of reception of psychostimulants. This medicine is practically not metabolized in a liver, removed from an organism by kidneys in an invariable look. Therefore it does not exert adverse impact on a liver, and here at renal pathology its removal is slowed down therefore smaller doses of Solian and constant control of the doctor are necessary.

Release form

Solian produce in the form of tablets 100, 200 and 400 mg, solution of 5% in ampoules for intramuscular injections and solution inside in bottles on 100 ml.

Indications to Solian's use

According to the instruction Solian use in treatment of schizophrenia. This mental disease progresses gradually, being shown by change of thinking, perception, the speech, feelings, social activity. In the people it is known as "split personality". Solian eliminates as productive symptomatology in the form of crazy thoughts and speeches, hallucinations, disturbances of thinking, and negative – reduced emotional activity, reduction of contacts with people around, affect flattening.

Contraindications

Solian is prohibited at intolerance of his components, in cases of prolaktinzavisimy tumors, tumors of bark of adrenal glands (pheochromocytoma), during pregnancy and a lactation, at people molozhe18 years (as clinical tests were not carried out), at a renal failure of heavy degree. Medicine is not recommended for combined use with hinagolidy, a levodopa, antiarrhytmic means 1A and 3 classes, tsizapridy, some antibiotics for intravenous administration, etc.

Carefully and surely under constant control of the doctor it is necessary to carry out treatment by this drug at patients with separate types of cardiological pathology (bradycardia, ventricular arrhythmias), at a renal failure at its initial stages, at a diabetes mellitus, at elderly, especially with dementia, Parkinson's disease, predisposition to a stroke and a thromboembolism.

Application instruction of Solian

Medicine is accepted inside, at different stages calculates a dose and a course and the psychiatrist changes.

If Solian's dosage is no more than 400 mg/days, then reception of means once in day is possible if more – it is necessary to divide it into 2 receptions. Usually if the negative symptomatology in the form of decrease in communication and socialization prevails, then Solian's dose makes 50 – 300 mg/days at intake (on average 100 mg), it is selected individually.

During bad psychotic attacks with productive symptomatology treatment there begin with Solian's introduction to a muscle several days to 400 mg/days, and then pass to oral administration on average 400 – 800 mg a day, a maximum permissible dosage of 1,2 g/days.

At permanent improvement of health of the patient it remains on an individual maintenance dose of drug.

Side effects of Solian

Depending on registration frequency adverse effects from treatment by Solian divide on very frequent, frequent, infrequent, rare and very rare. It is sometimes difficult to separate side effect from symptoms of schizophrenia.

From TsNS extrapyramidal disturbances (a tremor, dyskinesia, hypersalivation, etc.), acute dystonias (a spastic wryneck, a lockjaw, etc.), drowsiness in the afternoon, spasms, late dyskinesia of face muscles and language can meet.

From mentality of change in a type of sleep disorders, excess uneasiness, agitation.

From a GIT – locks, vomiting and nausea, from endocrine system – a galactorrhoea, an amenorrhea, a gynecomastia, erectile dysfunction, from heart and vessels – pressure decrease and heart rate, from blood – a leukopenia and an agranulocytosis.