Tayled

Tayled – antiallergic drug for treatment of reversible obstruction of respiratory tracts.

Pharmacological action of Tayled

Tayled – inhalation drug from group of stabilizers of membranes of mast cells. It is created on the basis of a nedokromil of sodium.

Extending during a breath on bronchial tubes of the different sizes, drug stabilizes membranes of mast cells, eosinophils, alveolar macrophages. As a result from them release of biologically active agents capable to cause immune and inflammatory responses in bronchial tubes is blocked. The histamine, leukotrienes and other active cytokines provoke a bronchospasm and obstruction. Release them at hyperreactivity of bronchial tubes the cold or contaminated air, steam inhalation of the irritating substances can cause both immune (allergens), and not immune factors, for example.

Tayled has antiinflammatory and antiallergic effect, without having the antihistaminic and expanding bronchial tubes properties. Tayled by 4 – 10 times surpasses the analog in antiinflammatory activity Intal. Drug begins to have medical effect only a week later from the beginning of a course therefore it does not treat drugs of the emergency help at a bronkhoobstruktion. This medicine eliminates hyperreactivity of bronchial tubes, improves breath function, extends remission and reduces the frequency, and also force of attacks of suffocation and cough at bronchial asthma and allergic cough.

In clinical practice good comments about Tayleda at treatment of infectious and dependent bronchial asthma are received. It высокобезопасен unlike other means for basic therapy of asthma.

Reduction of permeability of blood vessels mucous bronchial tubes belongs to the positive moments of use of Tayled which directly are not connected with his main mechanism of action that eliminates an edematous component of a bronkhoobstruktion.

Drug works locally, on walls of bronchial tubes accumulates up to 10% of Tayled, about 5% through mucous bronchial tubes are soaked up in blood and contacts proteins of plasma, other part gets into a GIT, but is soaked up from there a little (about 2%). Removal in an invariable look happens to urine and a stake.

Release form

Tayled release in the form of the dosed aerosol, the cylinder contains 112 doses, everyone on 2 mg of a nedokromil of sodium.

Indications to Tayled's use

According to the instruction Tayled apply as a part of basic therapy of bronchial asthma of different genesis easy and moderate severity, bronkhospastichesky reactions to physical effort, cold air, etc. Drug is effective also at an allergic bronchitis.

Contraindications

Tayled it is impossible to use at hypersensitivity to drug components, in 1 trimester of pregnancy and at children up to 2 years.

Application instruction of Tayled

The initial dose for adults, and also makes children of 2 years on 2 inhalations (4 mg) from 2 to 4 times a day, depending on response of an organism of the patient to a medical dose. Disappearance of "morning failures" of the volume of the forced exhalation (VFE) 1 second is one of criteria of effectively picked up therapy. Duration of a course of treatment can make from 4 to 6 weeks of continuous reception. The most admissible daily dose – 8 inhalations.

Before use it is necessary to stir up carefully a barrel with medicine and to take it vertically, having placed a thumb on its basis. After the greatest possible exhalation it is necessary to clasp densely a mouthpiece with lips, then to begin a breath and at the same time to spray one or two doses of drug. After a breath it is necessary to remove a mouthpiece from a mouth and whenever possible to hold the breath.

Tayled reduces the need for bronkhodilyatator and allows to reduce a dose of glucocorticoids in basic therapy at a concomitant use with it.

Side effects of Tayled

According to reviews Tayled is well had by patients, even at long reception. Occasionally slight symptoms in the form of feeling of bitterness and dryness in a mouth, nausea, a headache, cough or a hoarseness meet.