Tisercinum

Tisercinum – the synthetic psychotropic drug used for treatment of bipolar disorders and psychoses.

Pharmacological action of Tisercinum

Active component of Tisercinum renders the somnolent, antipsychotic, hypothermal, analgeziruyushchy, and also less expressed antiemetic, m-holinoblokiruyushchee and antihistaminic action. The maximum analgesic effect develops within half an hour after intramuscular introduction, and its duration usually makes four hours.

Besides, at use of Tisercinum the lowering of arterial pressure is observed.

The side effects caused by Tisercinum are less expressed, than other antipsychotic drugs.

Release form

Tisercinum is released in a look:

• Inodorous white round tablets which contain 25 mg of levomepromazinum. On 50 pieces in bottles from dark glass;
• Transparent, pale green color of solution for the injections containing in 1 ml 25 mg of active agent. In ampoules on 1 ml.

Tisercinum analogs on the mechanism of action are the drugs Aminazine and Propazine (in a dosage form of a dragee, solution for injections and tablets), and also a dragee Chlorpromazinum.

Indications to use of Tisercinum

According to the instruction Tisercinum is appointed for treatment of psychomotor excitement of various etiology, namely at:

• Psychoses (including intoksikatsionny and senile);
• Schizophrenia (both acute, and chronic);
• Bipolar disorders;
• Epilepsies;
• Oligophrenias.

Besides, use of Tisercinum is effective:

• At treatment of other mental disorders which proceed with persistent sleeplessness, alarm, agitation, phobias and panic;
• For strengthening of action of means for the general anesthesia, analgetics and antihistaminic drugs;
• For stopping of a pain syndrome at neuritis of a facial nerve, epileptiform neuralgia and shingles.

Contraindications

Use of Tisercinum is contraindicated in cases:

• At joint reception with anti-hypertensive means;
• At a granulocytopenia (oppression of a marrowy hemopoiesis);
• At closed-angle glaucoma;
• Against the background of a renal and liver failure of heavy degree;
• At overdose of means which have the oppressing effect on the central nervous system (for example, the general anesthetics, alcohol or somnolent drugs);
• At Parkinson's disease;
• In pediatrics (up to 12 years);
• At an ischuria;
• At a disease of multiple sclerosis;
• Against the background of chronic heart failure (in a decompensation stage);
• At a lactation;
• At a hemiplegia;
• At a myasthenia;
• At the expressed arterial hypotension;
• At a porphyria;
• At pregnancy (except use according to strict indications when the expected advantage exceeds the estimated harm done to both mother, and a fruit);
• At hypersensitivity to levomepromazinum and other fenotiazina.

Besides, extra care needs to be observed at purpose of Tisercinum against the background of:

• Epilepsies;
• Cardiovascular diseases in the anamnesis that is especially important for elderly patients with arrhythmias, disturbance of conductivity of a cardiac muscle, a syndrome of inborn lengthening of an interval of QT.

Tisercinum route of administration

The initial dose of Tisercinum according to the instruction varies from one to two pill taken several times a day. The maximum part of a daily dosage should be accepted before going to bed.

Gradually (on 25-50 mg a day) the daily dosage is increased to effective which, as a rule, makes 200-300 mg. After reduction of symptoms of a disease the dose is reduced to supporting which is defined individually by the doctor.

At impossibility to accept Tisercinum inside, the drug is administered parenterally: intravenously (kapelno) or intramusculary (deeply). A daily dosage – 75-100 mg which is divided into several injections. It is authorized to apply similar therapy only with observance of a bed rest, controlling pulse and pressure.

It is necessary to observe strictly ordered dosages to avoid use of Tisercinum in high doses that can bring to:

• To disturbance of conductivity in a cardiac muscle;
• Arterial hypotension;
• To extrapyramidal symptoms;
• To oppression of consciousness of various degree of manifestation (in certain cases – up to a coma);
• To epileptic seizures;
• To the expressed sedation.

Medicinal interaction of Tisercinum

It is necessary to be careful of a concomitant use of Tisercinum with:

• MAO inhibitors (because of strengthening of expressiveness of side effects);
• Anti-hypertensive means (because of the increasing risk of the expressed lowering of arterial pressure);
• Tricyclic antidepressants (because of strengthening of the arising anticholinergic effects which are shown as an ischuria, paralytic intestinal impassability and glaucoma);
• Peroral hypoglycemic means (because of decrease in their efficiency).

Side effects of Tisercinum

The most frequent disturbances of cardiovascular system at reception of Tisercinum according to reviews are orthostatic hypotension and a lowering of arterial pressure. Also it is possible to carry to disturbances of this system:

• Morganyi-Adams-Stokes's syndrome;
• Tachycardia;
• Lengthening of an interval of QT (expressed as tachycardia like "pirouette" and aritmogenny effect.

The side effects which are reflected in the central nervous system at reception of Tisercinum according to reviews most often are shown in a look:

• Epileptic seizures;
• Drowsiness;
• Increased fatigue;
• Dizzinesses;
• Malignant antipsychotic syndrome;
• Indistinctness of the speech;
• Confusion of consciousness;
• Extrapyramidal symptoms (with explicit dominance of an akineto-hypotonic syndrome);
• Increases in intracranial pressure.

Treat other disturbances caused by Tisercinum according to reviews:

• Decolouration of urine and dysfunction of an urination (urinary system);
• Agranulocytosis, pancytopenia, eosinophilia, leukopenia and thrombocytopenia (system of a hemopoiesis);
• Body degrowth, mastalgiya, in certain cases – disturbances of a menstrual cycle (endocrine system);
• Unpleasant feelings in a stomach, dryness in a mouth, vomiting, nausea, a lock, damage of a liver in the form of a cholestasia or jaundices (alimentary system).
• Anaphylactoid reactions, bronchospasm, peripheral hypostases, exfoliative dermatitis, throat hypostasis, small tortoiseshell (allergic reactions at which emergence reception of Tisercinum is stopped);
• Erythema, photosensitization, pigmentation (dermatological reactions).

In rare instances use of Tisercinum can lead to development of a hyperthermia.

A number of cases when against the background of long reception of Tisercinum adenoma of a hypophysis and adjournment in a crystalline lens and a cornea according to reviews developed is described.

Storage conditions

Tisercinum according to the instruction belongs to a number of strong substances and is released strictly on medical appointment. A period of storage of the tablets Tisercinum – 5 years, solution for injections – no more than 24 months.