Ursodezoksikholevy acid

Ursodezoksikholevy acid – hepatoprotective and cholagogue means.

Pharmacological properties of Ursodezoksikholevy acid

Ursodezoksikholevy acid by origin is bile acid. It possesses except the cholagogue and protecting a liver properties immunomodulatory action, reduces formation of stones in a gall bladder and reduces the content of cholesterol.

The mechanism of effect of Ursodezoksikholevy acid consists in stabilization of hepatic cells. Its molecules are capable to be built in structure of membranes of hepatocytes (hepatic cells) and to do them steadier against damage by aggressive environments. Due to formation of safe complexes with toxic bile acids of Ursodezoksikholevaya acid neutralizes them, preventing the damaging action on membranes of cells.

Drugs of Ursodezoksikholevy acid influence hepatic recirculation of bile acids (on their return absorption from intestines in bile), they reduce absorption of cholesterol in intestines and thus have gipokholesterinemichesky effect.

Connecting to cholesterol in contents of a gall bladder, this medicinal substance increases solubility of crystals of cholesterol, promotes destruction of gallstones and interferes with formation of new cholesteric concrements. Besides, drugs of Ursodezoksikholevy acid reduce formation of cholesterol directly in a liver, that is reduce the content of this substance in all organism.

Immunomodulatory influence of Ursodezoksikholevy acid on an organism consists in normalization of a lymphocyte activity and disturbance of an expression of antigens on cells of a liver and hepatic channels. Specialists in the field of hepathology give positive reviews about Ursodezoksikholevy acid as about the means which is authentically reducing liver fibrosis at primary biliary cirrhosis, a mucoviscidosis, alcoholic fatty regeneration of a liver.

Medicine in a small intestine is soaked up (in a lean and ileal gut), in 3 hours after inclusion in blood the maximum concentration is reached it. Regular administration of drugs of Ursodezoksikholevy acid leads to the fact that it becomes the main bile acid in blood. In an organism it is exposed to a number of transformations then in the form of metabolites it is removed with a stake, in insignificant quantity – with urine.

Form of production of Ursodezoksikholevy acid

According to the instruction medicine is issued in capsules on 250 mg. It is the main active ingredient of various pharmaceutical drugs of cholagogue action. On the basis of Ursodezoksikholevy acid such drugs as are created:

• Ursosan;
• Ursofalk;
• Urso;
• Урсолив;
• Урсодекс.

Indications to use

Ursodezoksikholevy acid according to the instruction is used in complex treatment of cholelithiasis if they have a cholesteric origin, and removal is impossible in their surgical or endoscopic way. Cholesteric stones by the size have to be no more than 2 cm after a lithotripsy (crushing of stones).

Ursodezoksikholevy acid appoint in cases of chronic active hepatitis with stagnation of bile, at primary biliary cirrhosis to a stage of active fibrosis, at mukovistsidozny damage of a liver, biliary a reflux esophagitis, an acute hepatitis.

According to Ursodezoksikholevaya acid helps at dyskinesia of biliary tract and cholecystopathies. One more field of its use – prevention of stagnation of bile at reception of hormonal contraceptive drugs, improvement of work of a liver at treatment by cytostatics, as supportive application at liver transplantation and other bodies.

Contraindications to use of Ursodezoksikholevy acid

According to the instruction drug is contraindicated at an acute inflammation in biliary tract and a bubble (cholecystitis, a cholangitis), at cirrhosis in a stage of the expressed activity and a decompensation, at nonspecific ulcer colitis, a disease Krone, the expressed disturbances of renal function. Individual intolerance – too a contraindication to Ursodezoksikholevy acid.

Application instruction

There are no age restrictions to use of this medicine, in need of Ursodezoksikholevuyu it is possible to appoint acid since the neonatality period. The dose is selected individually, depending on body weight and degree of manifestation of displays of a disease. The average dose in days makes up to 10 mg/kg, it is accepted once in the evening. Duration of reception and quantity of rates of Ursodezoksikholevy acid are determined by the doctor, they are various for different diseases. During treatment of times in 3 months determination of level of liver enzymes is required, and at dissolution of gallstones – time in 6 months an ultrasonic and X-ray analysis of a liver and biliary tract.

Side effect of Ursodezoksikholevy acid

According to the instruction drugs on the basis of Ursodezoksikholevy acid can sometimes cause temporary increase in level of liver enzymes, a skin itch, allergic skin manifestations, furnacing of gallstones, diarrhea.