The prices in Internet drugstores:
from 6288 rub.
Абилифай – antipsychotic means (neuroleptic).
Active agent – арипипразол:
Excipients of tablets: magnesium stearate, corn starch, cellulose microcrystallic, lactoses monohydrate, hydroxypropyl cellulose, and also dyes: in tablets of 5 mg – a varnish aluminum blue, in mg tablets 10 and 30 – ferrous oxide red, in tablets of 15 mg – ferrous oxide yellow.
Solution excipients: water for injections, sodium hydroxide, the tartaric acid granulated R-tsiklodekstrina sulfobutyl ether (Каптисол®).
In the form of solution of Abilifay it is applied to bystry stopping of acute conditions of excitement and behavioural disturbances at patients with schizophrenia and maniacal episodes at bipolar disorder of the I type when there is no impossibility of administration of drug inside.
In this dosage form drug should be accepted inside regardless of meal.
The recommended doses:
Solution for intramuscular introduction in oil
In this dosage form of Abilifay apply a short course at impossibility of administration of drug inside.
Solution is entered intramusculary – deeply into a big buttock or deltoid muscle, avoiding zones with the expressed hypodermic fatty tissue.
The initial dose makes 10 mg (contents of 1 bottle) in the form of a single injection. Effective single doses depending on circumstances are in range from 5,25 to 15 mg. The doctor can appoint the reduced dose (5,25 mg) on the basis of assessment of the general clinical condition of the patient taking into account the drugs which are already appointed to it for the supporting or emergency treatment. If necessary in 2 hours do the second injection. Within 24 hours it is not necessary to appoint more than 3 injections.
As soon as becomes possible, the patient is transferred to the tableted form of Abilifaya.
The most admissible daily dose makes 30 mg, at the same time it is necessary to consider all applied dosage forms of drug – solution and tablets.
At patients 65 years are more senior there is an increased risk of development of side effects therefore the doctor has to consider a question of decrease in an initial dose.
Dose adjustment of drug is required at simultaneous use of some other drugs. In case of the combined appointment with powerful inhibitors of isoenzymes of CYP3A4 and CYP2D6 the dose of an aripiprazol is reduced, after their cancellation – again increased. At the combined use with powerful inductors of an isoenzyme CYP3A4 the dose of an aripiprazol is increased, after cancellation of the inductor the dose is reduced.
Classification of side effects:
Possible side effects:
Solution of Abilifay is not intended for hypodermic and intravenous administration.
During treatment it is necessary to refrain from alcohol intake, driving and performance of potentially dangerous types of works.
Powerful CYP2D6 inhibitors (for example, quinidine) and CYP3A4 (for example, кетоконазол) reduce clearance of an aripiprazol at intake respectively by 52% and 38%. For this reason in need of use of a similar combination it is necessary to lower a dose of Abilifaya.
Carbamazepine – the powerful inductor CYP3A4 – reduces concentration of an aripiprazol and its active metabolite of a degidroaripiprazol. Similar reaction can be expected at simultaneous use of other powerful inductors CYP2D6 and CYP3A4.
Aripiprazol shows antagonism to alfa1-adrenoceptors therefore it is supposed that it can strengthen effect of hypotensive drugs.
It is necessary to be careful at simultaneous use of drugs which can break electrolytic balance or extend QT interval, and also with other medicines influencing the central nervous system.
At the combined use with benzodiazepines (for example, lorazepam) the risk of strengthening of sedation and development of orthostatic hypotension increases.
To store at a temperature of 15-25 ºС in dry, protected from light and the place, unavailable to children.
Period of validity:
Name of drug
Абилифай tablets of 5 mg 28 pieces
Абилифай tablets of 10 mg 28 pieces
Абилифай tablets of 15 mg 28 pieces
Абилифай тбл 10 mg No. 28, Bristol-Myers Squibb
Абилифай тбл 15 mg No. 28, Bristol-Myers Squibb
Абилифай tablets of 30 mg 28 pieces
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