Aertal

Aertal – the non-steroidal anti-inflammatory drug applied to removal of an inflammation, heat, pain at rheumatism, reduction of constraint of joints in the mornings and their swellings.

Dosage Form and Composition

Aertal Dosage Forms:

• Tablets, film-coated: biconvex and round (approx. 8 mm diameter), covered with a white film; engraved unilaterally with "And". Available in blister packs of 10 tablets within cardboard boxes containing 1, 2, 3, 4, 6, or 9 blisters.
• Powder for Oral Suspension: White to cream-colored powder. Packaged in three-layered cartons containing 20 units.
External
• Cream: Homogeneous white substance. Supplied in aluminum tubes (60 g) within cardboard packaging (1 tube per box).

Active Ingredient: Aceclofenac.

Per Tablet:

• Active Ingredient: Aceclofenac 100 mg
• Excipients: Croscarmellose Sodium, Microcrystalline Cellulose, Glyceryl Distearate (Type I), Povidone

Contents per Package:

• Active Ingredient: Aceclofenac 100 mg
• Auxiliary Ingredients: Sorbitol, Sodium Saccharin, Aspartame, Colloidal Silicon Dioxide, Hypromellose, Titanium Dioxide, Milk Fragrance, Caramel, and Cream Scent

Content per Gram of Cream:

• Aceclofenac (100% micronized) 15 mg
• Excipients: Methylparahydroxybenzoate, Propylparahydroxybenzoate, Liquid Paraffin, Wax Emulsion, and Water.

Indications for Use

Aertal is indicated for pain relief and reduction of inflammation in the following conditions:

• Lumbago
• Humeroscapular Periarthritis
• Soft Tissue Rheumatism
• Osteoarthrosis
• Ankylosing Spondylitis
• Pseudorheumatism
• Other Musculoskeletal Disorders

Aertal is also effective for treating dental abscesses.

The topical cream suppresses edema and erythema regardless of the underlying inflammation, providing local analgesic and anti-inflammatory effects.

Contraindications

• Ulcers, erosions, and bleeding from the gastrointestinal tract.
• Bronchospasm
• Small Tortoiseshell
• Rhinitis induced by aspirin and other nonsteroidal drugs
• Severe liver failure
• Disorders of the hematopoiesis process
• Hyperkalemia
• Breastfeeding and Pregnancy
• Hypersensitivity to the active ingredient or excipients of the drug.

Aertal is contraindicated for children under 18 years of age.

Use with caution in patients with kidney disease, liver disease, gastrointestinal disorders, bronchial asthma, hypertension, ischemia, chronic liver and/or renal failure, diabetes, peripheral artery disease, advanced age, alcohol abuse, nicotine use, or long-term intake of nonsteroidal anti-inflammatory drugs (NSAIDs).

Contraindications for topical Aertal cream include compromised skin integrity at the site of application.

Administration Route and Dosage

Aertal tablets should not be chewed or crushed. The prescribed therapeutic dosage averages 100 mg daily (2 tablets), administered in two divided doses (morning and evening).

Aertal powder for oral administration may be used to prepare a suspension when rapid pain relief is needed. For the treatment of these conditions, administer one bag in the morning and one in the evening. To prepare the suspension: dissolve the contents of the packet in 40–60 mL of water and consume the mixture immediately.

Aertal cream is intended for external use only; do not apply under occlusive bandages.

Cream is rubbed by the easy movements on area of possible defeat 3 times a day in quantity at the rate of 1,5-2,0 g (about a size of a pea) on 5-7 ^cm2 of a body surface.

Adverse Effects

Use of Aertal may adversely affect various organ systems:

• Digestive system: vomiting, diarrhea, epigastric pain, colic, flatulence, nausea, ulcers and erosions, stomatitis, hepatitis, and pancreatitis;
• Central and peripheral nervous system: dizziness, sleep disturbances, irritability, depression, paresthesia, vertigo, restlessness, tremor, disorientation, meningitis, and impairments of memory, vision, or sensation.
• Other conditions include allergies, edema, renal insufficiency, nephritis, proteinuria, hematuria, leukopenia, agranulocytosis, anemia, thrombocytopenia, hypertension, and heart failure.

Special Instructions

Aertal may reduce the efficacy of antihypertensive medications and diuretics. When combined with potassium-sparing diuretics, it can cause hyperkalemia or hyperglycemia.

The risk of adverse effects increases when Aertal is used concurrently with glucocorticosteroids or other nonsteroidal drugs. Additionally, the drug may increase the nephrotoxicity of cyclosporine.

Exercise caution in patients with renal, hepatic, or cardiac failure, as well as those at risk for developing hyposthenuria.

Use Aertal cautiously alongside diuretic therapy in elderly patients due to an increased risk of hypovolemia.

Patients with fructose intolerance should not be prescribed acyclofenac powder, as it contains 2640 mg of sorbitol, which may provoke gastric disturbances or diarrhea.

Patients with phenylketonuria must be aware that each powder sachet contains 5.61 mg of phenylalanine.

Patients should avoid operating complex machinery or driving vehicles if they experience dizziness, weakness, or other central nervous system disturbances while taking Aertal.

Analogs

The direct analogue of Aertal is Asinak.

Drugs within the same pharmacological group sharing a similar mechanism of action include: Adolor, Bioran, Voltaren, Diclofenac, Dolak, Dolomin, Indometacin, Ketalgin, Ketanov, Naklofen, Ortophen, Panoxen, Flotak, Hondrofen, and others.

Terms and storage conditions

Store in a location inaccessible to children.

• Tablets: Store at temperatures up to 25°C; shelf life is 3 years.
• Powder: Store at temperatures up to 30°C; shelf life is 4 years.
• Cream: Store at temperatures up to 25°C; shelf life is 2 years.