Tsifran

Tsifran – antibacterial drug of group of hinolonov/ftorkhinolon.

Pharmacological action of Tsifran

Tsifran treats antimicrobic drugs of a broad spectrum of activity which main operating component is ciprofloxacin. At the heart of therapeutic influence of medicine – the mechanism of inhibition of enzyme of bacteria and disturbance of synthesis of their DNA. Besides, Tsifran is capable to increase permeability of a cellular cover of harmful microorganisms (in particular, bacteria) and to have bactericidal effect on them. Both the bacteria in a reproduction phase and which are in rest are subject to effect of drug.

Tsifran is active concerning a number of aerobic gram-negative bacteria among which there is Enterobacter spp, Escherichia coli, Citrobacter spp, Shigella Spp, Morganella morganii, Moraxella spp, Salmonella spp and others. Tsifran's activity concerning aerobic gram-positive bacteria is also noted: Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae and some other, including strains which produce a penicillinase. At last, drug is active concerning intracellular bacteria: Brucella spp, Chlamydia trachomatis, Legionella spp, Mycoplasma hominis.

However the instruction to Tsifran notes resistance of anaerobic bacteria to medicine.

The post-antibiotic effect after administration of drug lasts to 6 h that allows to prevent the further growth of bacteria.

Besides, treatment by Tsifran does not break natural microflora of a vagina and intestines.

Release form

In pharmacy chains three forms of drug are available:

• Tablets with a mass fraction of ciprofloxacin 250 or 500 of mg. Tablets are covered with a cover and packed into a cardboard pack in number of 10 or 100 pieces;
• Solution for infusions with the content of ciprofloxacin in number of 2 mg in 1 ml of Tsifran. Content of drug rolled into one equals 100 ml. The bottle is placed in a box;
• Drops are eye. 1 ml of drops contains 3 mg of ciprofloxacin. Drops are packed into a dark glass bottle, placed in a cardboard pack.

Indications to Tsifran's use

Indications to Tsifran are the infectious and inflammatory diseases caused by the microorganisms sensitive to effect of drug. According to the instruction to Tsifran drug is effective at the following diseases:

• at infections of urinogenital system (including at chronic and acute pyelonephritis, cystitis, prostatitis, an epididymite);
• at respiratory infections to which carry a bronkhopnevomeniya, pneumonia, an exacerbation of chronic bronchitis, bronchitis in an acute form, the pleurisy, an empyema infected bronchiectasias, lung abscesses;
• at gonorrhea, an urethritis, a proctitis, pharyngitis, including at the forms caused by resistant gonokokka;
• at infections of ENT organs, among them average and outside otitis, mastoiditis, sinusitis;
• at infections of soft tissues and skin, among them – the wounds and burns infected ulcers, cellulitises, abscesses;
• at GIT infections, including peritonitis, a cholangitis, a typhoid, intraabdominal abscesses, an empyema of a gall bladder;
• at infectious and inflammatory diseases of bodies of a small pelvis, including endometritis and salpingitis;
• at infections of joints and bones, among them chronic and acute osteomyelitis, septic arthritis;
• at a septicaemia, bacteremia, infections at patients with the weakened immune system.

The instruction to Tsifran describes efficiency in/in administrations of drug at prevention of postoperative infections.

Contraindications

Treatment by Tsifran is not recommended in case of existence of hypersensitivity to hinola, in particular, to ciprofloxacin. Also contraindications are pregnancy and a lactation, age up to 12 years.

Tsifran's use by some groups of patients is admissible only on condition of careful medical control during treatment, treat those:

• patients with the expressed atherosclerosis of vessels of a brain;
• patients with disturbances of cerebral circulation;
• patients with the diagnosed mental diseases;
• patients with an epileptic syndrome and epilepsy;
• patients with the expressed liver and/or renal failure;
• patients of advanced age.

Application instruction of Tsifran

The dosage at treatment by Tsifran is established strictly individually, proceeding from disease severity, type of the activator, body weight, age of the patient and function of kidneys.

Tsifran is shown to children after 12 years in number of 5-10 mg/kg of body weight a day. At the same time the dosage is divided into two receptions. It is preferable to take a pill before food.

Tsifran in a look in/in infusions by the adult is entered in number of 200 mg twice a day at infections of lower parts of extremities and urinary tract. The drug is administered slowly. At other infections it is necessary to enter Tsifran with the same speed in number of 200 mg each 12 h.

At a septicaemia and bacteremia each 12 h enter up to 400 mg of drug.

In case of the expressed disturbances of kidneys the daily dose is reduced twice.

Duration in/in uses weighing 200 mg of Tsifran equals 60 min.

In certain cases after a course into Tsifran's introductions it is necessary to pass to oral administration of drug.

Duration of treatment by Tsifran and analogs of drug is defined by the doctor on the basis of individual indicators of the patient. Not less than 5-7 days at acute infectious diseases are recommended to carry out treatment, after disappearance of clinical symptoms of an infection prolong a course of treatment for 3 days.

About 1-2 drops in the lower conjunctival sac of a sore eye in each 4 h at diseases of the easy and average Art. of weight are recommended to dig in eye drops. In case of an indication severe disease to Tsifran are as follows: each hour on 2 drops till the moment when there occurs improvement. After that the dose of drug is reduced.

Side effects of Tsifran

Tsifran's use and analogs of drug is in rare instances capable to cause a number of undesirable reactions. It is necessary to study their list prior to reception:

• abdominal pain, meteorism, vomiting, nausea, hepatitis;
• paresthesias, headache, irritability, dizziness, confusion of consciousness, migraine, faint, depression, tremor of extremities;
• disturbances of sense of smell, sight and taste, decrease in hearing;
• disturbances of a cordial rhythm, tachycardia;
• leukopenia, eosinophilia, anemia, leukocytosis, hemolitic anemia, thrombocytosis;
• prothrombinopenia, hyperglycemia, increase in activity of hepatic transaminases;
• hamaturia, glomerulonephritis, polyuria, dysuria, ischuria, urethral bleedings;
• arthralgia, mialgiya, tendovaginitis, arthritis, ruptures of sinews;
• the general weakness, photosensitivity, superinfections (in the form of candidiasis, pseudomembranous colitis).

Drug analogs

To the drugs similar on an image of action and structure to Tsifran, belong:

• Basidzhen;
• Afenoksin;
• Altsipro;
• Ifitsipro;
• Kvintor;
• Kvipro;
• Oftotsipro, etc.

Storage conditions

Tsifran is recommended to store in the dry place at a temperature up to 25 °C, far from sunshine. The period of validity makes 2 years.