Delagil
Application instruction:
Delagil – antiprotozoan drug of immunodepressive and antiinflammatory effect.
Form of release and structure
Dosage form – tablets: a flat form with slanted edge, white or almost white color, have no smell (on 10 pieces in blisters, in a cardboard pack on 3 blisters).
The operating component – chloroquine (in the form of phosphate), contains in 1 tablet 250 mg.
Excipients: the polyacrylic acid (carbomer 934P), silicon dioxide colloid hydrophobic (R972 aerosil), starch corn, magnesium stearate, polivinilbutirat (мовиталь B30T), talc.
Indications to use
- Prevention and treatment of all types of malaria;
- Subacute and chronic form of a system lupus erythematosus;
- Abenteric amebiasis;
- Pseudorheumatism;
- Photodermatosis;
- Amoebic abscess of a liver;
- Scleroderma.
Contraindications
- Liver and/or renal failure;
- Heavy disturbances of a rhythm;
- Oppression of a marrowy hemopoiesis;
- Neutropenia;
- Psoriasis arthritis;
- Purpurinuria;
- Period of pregnancy and breastfeeding;
- Hypersensitivity to drug components.
With care apply Delagil at treatment of patients with epilepsy, a retinopathy, deficit dehydrogenase glyukozo-6-phosphate.
Route of administration and dosage
Pill is taken orally.
Depending on clinical indications the following dosing is recommended:
- Treatment of malaria: the 1st day – 4 tablets once, then in 6-8 hours – 2 pieces, in the 2nd and 3rd day of therapy on 3 pieces of 1 times a day;
- Prevention of malaria: on 2 tablets 2 times in the first week, further – on 2 pieces every 7 days;
- System lupus erythematosus: on 1-2 tablets a day;
- Amebiasis: 7 days – on 2 tablets 3 times a day, then 7 days – on 1 piece 3 times a day, further within 2-6 months – on 3 pieces 2 times a week;
- Pseudorheumatism: on 2 tablets 2 times a day within 7 days, further – on 2 pieces of 1 times a day within a year;
- Photodermatosis: on 1 tablet of 1 times a day within 7 days, further – on 2-3 pieces a week.
Side effects
Use of Delagil can cause side effects:
- From cardiovascular system: a lowering of arterial pressure, damage of a myocardium with changes on the electrocardiogram;
- From the alimentary system: nausea, gastralgia, vomiting;
- From sense bodys: in case of long reception – a ring in ears, opacification of a cornea, a vision disorder, damage of a retina;
- From a nervous system: sleep disorders, dizziness, psychoses, headache, epileptic seizures;
- Allergic reactions: photosensitization, dermatitis;
- Others: leukopenia, mialgiya, discoloration of hair and skin.
Special instructions
Treatment has to be followed by regular performing the general blood tests and surveys of the oculist.
Medicinal interaction
The combined use of drug in combination with other antimalarial means can become the reason of opposite effects.
At simultaneous use with Delagil:
- Gold drugs, phenylbutazone, Penicillaminum, levamisole, cytostatics – increase probability of damage of skin and an aplasia of marrow;
- Glucocorticosteroids (GKS) – increase risk of development of a cardiomyopathy and myopathy;
- Cardiac glycosides – increase glikozidny intoxication;
- Ethanol – increases a hepatotoxic;
- Monoamine oxidase inhibitors (MAO) – strengthen risk of development of a neurotoxicity;
- Cimetidinum – increases the level of concentration of drug in blood;
- Antacids – break chloroquine absorption.
Terms and storage conditions
To store at a temperature up to 25 °C. To protect from children.
Period of validity – 5 years.
Name of drug
Price
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