Glutoksim

Glutoksim – the immunostimulating drug participating in regulation of metabolic processes in fabrics and cells.

Form of release and structure

Glutoksim release in the form of solution for injections: the transparent, poorly painted or colourless liquid with a slight acetic smell or almost inodorous (in ampoules from neutral glass on 1 or 2 ml, on 5 or 10 ampoules in a blister strip packaging, on 1, 2, 5 or 10 packagings in a cardboard pack in a set with the scarificator or a knife ampoule; with notches, points and rings of a break scarificators or knives ampoule are not applied to packagings of ampoules).

Is a part of 1 ml of injection solution:

• Active ingredient: Dinatrium Glutamil-Tsisteinil-Glitsin – 5, 10 or 30 mg;
• Auxiliary components: divorced acetic acid, sodium acetate, water for injections.

Indications to use

Glutoksim is recommended to use as prophylactic and therapy of the secondary immunodeficiency associated with radiation, chemical and infectious factors, for recovery of the suppressed immune responses and reduction of depression of a marrowy hemopoiesis. Drug is also used for the purpose of increase in resistance of an organism to various pathological influences of physical and/or chemical factors, infectious agents (radiation, intoxication, etc.).

Glutoksim's injections are shown:

• Chronic viral hepatitis In and With (as a gepatoprotektor);
• Chronic obstructive diseases of lungs (for activation of therapeutic effect of antibacterial agents);
• The postoperative period (for the purpose of prevention of purulent complications);
• Malignant new growths (as a part of complex therapy);
• Oncology (for treatment and prevention of toxic answers beam and chemotherapy, for the purpose of decrease gepato-both haemo toxic action, and assistance to effective recovery of a marrowy hemopoiesis when performing antineoplastic therapy);
• Severe common forms of tuberculosis of all localizations (as a part of complex therapy, in the presence of the medicinal resilience of mycobacteria of tuberculosis);
• Chronic hepatitis at tubercular patients against the background of antitubercular treatment (for the purpose of prevention of aggravations);
• Antitubercular therapy (for treatment of toxic complications);
• Psoriasis, including medium-weight and severe forms with existence of an arthropathy, erythrosis (as a part of complex therapy);
• Diseases of various genesis (for elimination or smoothing of manifestations of a nonspecific syndrome of a disease: the increased painful sensitivity, fatigue, anemia, a loss of appetite).

Contraindications

Glutoksim's use is contraindicated at individual hypersensitivity to his components.

It is not recommended to use drug at pregnancy and during a lactation (breastfeeding) as clinical trials on safety of its use during these periods were not conducted.

Route of administration and dosage

Solution is entered intravenously (in/in), intramusculary (in oil) and subcutaneously (п / to).

The recommended dosing mode: daily on 5-40 mg (a course – 50-300 mg), depending on character of a disease/state, namely:

• Prevention – in oil daily on 5-10 mg for 2 weeks;
• Tuberculosis (as a part of complex therapy) – in oil daily once a day on 60 mg for the first 10 days, the next 20 days – in oil every other day, that is one injection of 60 mg in 2 days (if it is necessary, 1-6 months later conduct a repeated course);
• Psoriasis (as a part of complex therapy) – in oil daily in a daily dose of 10 mg for 15 days, then 5 more weeks on 10 mg 2 times a week; a full course of therapy – 25 injections;
• Chemotherapy in oncology (as means of maintenance) – п / to on 60 mg in 1,5-2 hours prior to use of antineoplastic drugs; further between chemotherapy courses solution is entered п / to on 60 mg every other day; when carrying out the following course of chemotherapy the scheme repeats;
• Radiation therapy (as means of maintenance) – п / to on 60 mg ^1/2-1 hour later after another session of radiation, 1 times in 2 days during all course of radiation therapy.

Side effects

At certain patients perhaps slight increase of body temperature to 37,1-37,5 °C, painful feelings in the place of an injection (for morbidity reduction it is possible to administer the drug together with 1-2 ml 0,5% of solution of novocaine).

Special instructions

As solution carrier at infusional introduction solution of glucose or isotonic solution of sodium chloride use 5%.

Glutoksim is allowed to enter in one syringe with medicines, soluble in water.

Medicinal interaction

In case of the combined use with an isoniazid, rifampicin, rifabutiny, Cycloserinum, kapreomitsiny, levofloksatsiny Glutoksim exponentiates bacteriostatic effect on Mycobacterium tuberculosis, and in combination with an anthracycline antibiotic doxorubicine and the alkylating means etopozidy – on tumor cells.

Glutoksim reduces therapeutic effect of verapamil and nifedipine.

Meloksikam, indometacin (inhibitors of a cyclooxygenase way of oxidation of arachidonic acid) reduce or completely suppress pharmacological action of Glutamil-Tsisteinil-Glitsin of dinatrium.

Terms and storage conditions

To store in the place, dry, dark, unavailable to children, at a temperature not above 25 °C.

Period of validity – 3 years.