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L-lysine эсцинат

Концентрат для приготовления раствора для внутривенного введения L-лизина эсцинатL-lysine эсцинат – angioprotektorny drug with venotoniziruyushchy and moderate hypoglycemic action.

Form of release and structure

Dosage form – a concentrate for preparation of solution for intravenous (in/in) introductions (on 5 ml in ampoules, in blister strip packagings on 5 pieces, in a cardboard pack 2 packagings).

Active agent – a L-lysine эсцинат, in 1 ml of a concentrate – 1 mg.

Indications to use

  • Traumatic or postoperative hypostasis back or brain;
  • Hypostases of soft tissues of various localization of postoperative and posttraumatic genesis;
  • Hypostases against the background of disorder of peripheric venous circulation.


  • The expressed renal failures and/or a liver;
  • Bleedings;
  • Period of pregnancy and breastfeeding;
  • Age up to 18 years;
  • Intolerance of components of drug.

Route of administration and dosage

L-lysine эсцинат it is intended only for in/in slow drop or jet introduction. Intra arterial introduction is strictly forbidden!

The recommended daily dose of drug – 5-10 ml.

It is impossible to use drug without preliminary cultivation.

Solution for in/in introductions is prepared by dissolution of a concentrate in 0,9% chloride sodium solution:

  • Solution for infusions: in 50-100 ml;
  • Solution for jet introduction: in 10-15 ml.

At a craniocereberal injury, postoperative hypostases back and a brain with the phenomena of hypostasis swelling, extensive puffiness of soft tissues owing to traumatizing and others life-threatening conditions of the patient it is necessary to increase a daily dose to 20 ml and to enter in equal shares into 2 receptions. The course of use of drug depends on clinical indications and efficiency of therapy and can proceed from 2 to 8 days.

Side effects

Against the background of individual intolerance of a L-lysine of an estsinat development of undesirable effects is possible:

  • Nervous system: tremor, dizziness, headache; in isolated cases – a short-term loss of consciousness, an ataxy;
  • Alimentary system: nausea; in isolated cases – diarrhea, vomiting;
  • Respiratory system: isolated cases – short wind, dry cough, feeling of shortage of air, a bronkhoobstruktion;
  • Gepatobiliarny system: increase in activity of bilirubin and transaminases;
  • Cardiovascular system: a lowering of arterial pressure (ABP), tachycardia, increase in the ABP, pain behind a breast;
  • Allergic reactions: itch, petekhialny, papular or erythematic skin rash, small tortoiseshell, fever, dermahemia of the person and lips; in isolated cases – an acute anaphylaxis, a Quincke's edema;
  • Local reactions: burning sensation on the vein course (at introduction), hand pain, phlebitis;
  • Others: heat, general weakness, fever.

Special instructions

Purpose of drug the patient with gepatokholetsistity in some cases can cause short-term increase in bilirubin and activity of transaminases which does not pose a threat and does not demand drug withdrawal.

Ethanol of 23,8%, or to 2,4 ml in one-time and to 6,1 ml to a daily dose is a part of a concentrate.

With care it is necessary to appoint drug at epilepsy, alcoholism, liver diseases.

Use of a L-lysine of an estsinat can exert impact on ability of the patient to management transport means and mechanisms.

Medicinal interaction

Aminoglycosides at simultaneous use from a L-lysine estsinaty can increase the nephrotoxicity.

At the long previous therapy by anticoagulants or need of their combination to drug it is necessary to adjust doses of anticoagulants under control of a prothrombin ratio.

The accompanying therapy by antibiotics of a tsefalosporinovy row complicates linkng of a L-lysine of an estsinat with proteins of plasma and increases risk of emergence of its side effects against the background of increase in concentration of a free estsin in blood.

It is necessary to consider existence of 96% of alcohol as a part of drug at co-administration of other medicines.

Terms and storage conditions

To store in the place protected from light at a temperature of 15-25 °C. To protect from children.

Period of validity – 2 years.

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