Rifampicin
Application instruction:
Rifampicin – antibacterial antitubercular drug.
Pharmacological action
Rifampicin suppresses tubercular mycobacteria, a brucella, chlamydias, a legionella, a rickettsia, a leprosy mycobacterium, staphylococcus, a clostridium, streptococci, gonokokk, meningokokk.
Release form
Rifampicin is produced in capsules, powder for solution cultivation, tablets.
Indications to Rifampicin use
The antibiotic is applied to the treatment of all forms of tuberculosis, a leprosy, infections caused by bacteria, sensitive to Rifampitsin, and a brucellosis. In most cases the antibiotic is appointed as a part of complex treatment of the specified diseases.
There are good reviews of Rifampicin as prophylactic at meningitis. The antibiotic is used for the prevention of development of a disease in the people who were in close contact with bacilli carriers of a meningokokk or with the patients with meningitis of a meningococcal origin.
Route of administration
Tablets and capsules of Rifampicin recommend to take for half an hour to food.
At tuberculosis the antibiotic is combined with antitubercular drugs: Ethambutolum, streptomycin, isoniazid or Pyrazinamidum. To adults whose weight does not exceed 50 kg is shown to accept 450 mg of an antibiotic in knocks if weight more than 50 kg – 600 mg.
To children, including newborns, in days it is possible to give 10-20 mg of Rifampicin on kilogram of weight. An admissible daily dose at the same time – 600 mg.
For treatment of lepromatous, boundary types of a leprosy by the adult recommend to accept 600 mg of drug. Accept it once a month. Are in addition appointed Dapsone – 100 mg a day and Clofazimine – 300 mg a month and 50 mg a day. Children are given 10 mg of Rifampicin on kilogram of weight in combination with Dapsone, Clofazimine. Treatment lasts not less than two years.
For treatment tuberculoid, boundary tuberculoid leprosy types adults need to accept 600 mg of Rifampicin a month and 100 mg of Dapsone a day. Children are given an antibiotic once month in a dosage of 10 mg/kg, and Dapsone – in a daily dosage of 1-2 mg/kg. Treatment lasts half a year.
At various infections caused by bacteria, sensitive to an antibiotic, the dosage of 0,6-1,2 g is shown to the adult patient; to the child – 10-20 mg/kg. Two times a day accept drug.
At a brucellosis use of Rifampicin in a dosage of 900 mg a day is shown. Therapy lasts 45 days.
Intravenously the antibiotic is entered at common and acute forms of a pulmonary tuberculosis, at purulent heavy processes or when reception of tablets or capsules for the patient is physically impossible.
Daily dosage at intravenous administration of an antibiotic – 0,45 g or 0,6 g (if a hard case).
Side effects
Rifampicin can cause diarrhea, dizziness, nausea, deterioration in sight and appetite, fever, vomiting, a headache.
There are reviews of Rifampicin from the patients accepting it indicating that, erosive gastritis can appear from behind an antibiotic, begin allergic reaction, a disorientation, an exacerbation of gout.
At overdose of Rifampicin lungs swell, there is a confusion of consciousness, spasms begin. To the patient wash out a stomach, carry out a profound diuresis, give absorbent carbon.
Contraindications
Rifampicin according to the instruction is contraindicated at jaundice, a chronic renal failure, a severe form of a pulmonary heart, infectious hepatitis, during pregnancy, feeding by a breast.
Name of drug
Price
Drugstore
Rifampicin капс 150 mg No. 100, Belmedpreparata (Minsk)
193 rub.
Network of the Moscow drugstores of IFCEven if heart of the person does not fight, then he all the same can live during a long period, as the Norwegian fisherman Jan Revsdal showed us. Its "motor" stopped for 4 hours after the fisherman got lost and fell asleep in snow.
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